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CAZyme Information: MGYG000001565_00131

You are here: Home > Sequence: MGYG000001565_00131

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species CAG-103 sp900757655
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Oscillospiraceae; CAG-103; CAG-103 sp900757655
CAZyme ID MGYG000001565_00131
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
378 MGYG000001565_1|CGC2 40403.49 6.5673
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001565 2153717 MAG United States North America
Gene Location Start: 137421;  End: 138557  Strand: +

Full Sequence      Download help

MNFLFTCGGT  AGHINPALAV  AGILRDRMPD  CGILFVGANG  KMETDLVPRA  GYDIVTVEVT60
NIHRSLKPSE  IAYNFRSLHN  ARQATKDARK  IIEDFKPDIA  IGTGGYVCYP  VLKAAAQLGI120
PTIVHESNAV  PGLTTKMLAG  AVDRILVGFE  ESKQHYSEQE  KVVVTGTPVR  GAFTACSKAE180
AKRQLGLDPD  KPLVVSVWGS  LGASYMNEVM  TAFITRAAVT  DAPFALIHSA  GRNGYEKMHT240
ALLEKCPADL  AAHGMDVRPY  IYDMPLVMDA  ADLVLCRAGA  STLAELTCIG  KPAILIPSPN300
VTNNHQERNA  RVLEHAGGAK  VLLEGAFTAD  DLYNLVSDLL  SDPAQLAQMA  ENMRAAGTAD360
AAERIADLVL  KLADRHGK378

Enzyme Prediction      help

No EC number prediction in MGYG000001565_00131.

CAZyme Signature Domains help

Created with Snap1837567594113132151170189207226245264283302321340359197361GT28
Family Start End Evalue family coverage
GT28 197 361 8e-46 0.9681528662420382

CDD Domains      download full data without filtering help

Created with Snap18375675941131321511701892072262452642833023213403591375murG3368GT28_MurG1373MurG1369murG199365Glyco_tran_28_C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 1.08e-128 1 375 2 357
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 6.00e-126 3 368 2 350
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 2.54e-105 1 373 1 355
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 9.50e-95 1 369 1 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam04101 Glyco_tran_28_C 6.81e-37 199 365 7 166
Glycosyltransferase family 28 C-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.

CAZyme Hits      help

Created with Snap18375675941131321511701892072262452642833023213403594372QCI58785.1|GT281372QNL43650.1|GT281372BCK80743.1|GT284372QUO37394.1|GT281376QIA29973.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
QCI58785.1 4.80e-134 4 372 9 376
QNL43650.1 1.88e-132 1 372 1 371
BCK80743.1 7.35e-132 1 372 1 370
QUO37394.1 1.28e-131 4 372 9 376
QIA29973.1 1.64e-131 1 376 1 373

PDB Hits      download full data without filtering help

Created with Snap183756759411313215117018920722624526428330232134035923733S2U_A43727D1I_A83731F0K_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 5.86e-50 2 373 4 355
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
7D1I_A 3.55e-47 4 372 13 365
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
1F0K_A 2.14e-43 8 373 14 354
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18375675941131321511701892072262452642833023213403591369sp|A3DE27|MURG_ACET21369sp|B0K8K7|MURG_THEP31369sp|B0K3H0|MURG_THEPX1369sp|Q8R9G6|MURG_CALS41365sp|A6TS61|MURG_ALKMQ
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A3DE27 1.98e-98 1 369 1 359
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=murG PE=3 SV=1
B0K8K7 7.00e-95 1 369 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=murG PE=3 SV=1
B0K3H0 7.00e-95 1 369 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter sp. (strain X514) OX=399726 GN=murG PE=3 SV=1
Q8R9G6 7.94e-94 1 369 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) OX=273068 GN=murG PE=3 SV=1
A6TS61 2.84e-83 1 365 1 356
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Alkaliphilus metalliredigens (strain QYMF) OX=293826 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000057 0.000001 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001565_00131.