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CAZyme Information: MGYG000001860_00505

You are here: Home > Sequence: MGYG000001860_00505

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UMGS172 sp900539855
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Acutalibacteraceae; UMGS172; UMGS172 sp900539855
CAZyme ID MGYG000001860_00505
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
373 MGYG000001860_8|CGC1 40118.62 9.238
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001860 1972754 MAG Denmark Europe
Gene Location Start: 38789;  End: 39910  Strand: -

Full Sequence      Download help

MHYLFAGGGT  AGHINPAIAV  AGYLKKADPD  CRISFIGTKK  GMESRLVPMA  GYDFYTIDVA60
GFQRKLTVKN  IFKNISAAFK  AITSSGRSRK  LLKKLQPDVV  IGTGGYVCGP  VVMEAAKLGI120
KTAVHESNAF  PGVTIKMLAP  RVDVVMLGMK  AAEERLKCKN  PPIVTGNPIR  SQLTALSRNE180
ARKKLGIPED  ADMVLSFGGS  LGAKYINKAV  VSLAKAAANS  GSFYLFHGTG  RSGYGEFMSD240
LESAGGNADD  CHVNIYEYID  NMDVLMAAAD  IVVCRAGAMT  INELEVCKKP  SVLIPSPYVA300
ENHQFHNAMA  LKNAGAAEII  EEKDLIGERL  LSTIRSLLGD  KQKLCRMSEN  AGREAIVDAD360
RRIADILMNL  QTK373

Enzyme Prediction      help

No EC number prediction in MGYG000001860_00505.

CAZyme Signature Domains help

Created with Snap1837557493111130149167186205223242261279298317335354194356GT28
Family Start End Evalue family coverage
GT28 194 356 9.3e-48 0.9681528662420382

CDD Domains      download full data without filtering help

Created with Snap18375574931111301491671862052232422612792983173353544366GT28_MurG1370murG4367MurG4367murG193363Glyco_tran_28_C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd03785 GT28_MurG 1.35e-136 4 366 3 350
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
PRK00726 murG 4.85e-134 1 370 2 354
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
COG0707 MurG 4.38e-104 4 367 4 351
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 2.04e-98 4 367 4 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam04101 Glyco_tran_28_C 1.31e-45 193 363 1 166
Glycosyltransferase family 28 C-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.

CAZyme Hits      help

Created with Snap18375574931111301491671862052232422612792983173353541363QNK41610.1|GT281367ANU55131.1|GT281367QQR30895.1|GT281367ASB41635.1|GT281370QIA41876.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
QNK41610.1 6.36e-115 1 363 1 362
ANU55131.1 2.48e-114 1 367 1 366
QQR30895.1 2.48e-114 1 367 1 366
ASB41635.1 2.48e-114 1 367 1 366
QIA41876.1 5.25e-111 1 370 1 371

PDB Hits      download full data without filtering help

Created with Snap183755749311113014916718620522324226127929831733535483651F0K_A23707D1I_A43703S2U_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
1F0K_A 5.99e-47 8 365 14 348
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
7D1I_A 1.26e-45 2 370 11 365
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
3S2U_A 1.13e-39 4 370 6 354
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18375574931111301491671862052232422612792983173353541370sp|A3DE27|MURG_ACET21370sp|B8I6H3|MURG_RUMCH1370sp|Q8R9G6|MURG_CALS41370sp|B0K3H0|MURG_THEPX1370sp|B0K8K7|MURG_THEP3
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A3DE27 4.17e-107 1 370 1 362
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=murG PE=3 SV=1
B8I6H3 9.49e-94 1 370 1 363
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) OX=394503 GN=murG PE=3 SV=1
Q8R9G6 1.52e-92 1 370 1 363
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) OX=273068 GN=murG PE=3 SV=1
B0K3H0 8.61e-92 1 370 1 363
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter sp. (strain X514) OX=399726 GN=murG PE=3 SV=1
B0K8K7 8.61e-92 1 370 1 363
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000060 0.000001 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001860_00505.