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CAZyme Information: MGYG000001947_00093

You are here: Home > Sequence: MGYG000001947_00093

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UBA1777 sp900549545
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Oscillospiraceae; UBA1777; UBA1777 sp900549545
CAZyme ID MGYG000001947_00093
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
373 MGYG000001947_1|CGC2 39915.26 6.605
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001947 2112314 MAG Denmark Europe
Gene Location Start: 90342;  End: 91463  Strand: +

Full Sequence      Download help

MNFILTCGGT  AGHINPALAV  AGRLRELMPD  CGILFLGAEG  KMEMELVPRE  GYEIKPLKIT60
NISRGKSLSA  IKHNIETLKN  VLVSTKEAKK  IIAEFKPDAV  IGTGGYVCYP  VLKAASSMGI120
PTAIHESNAV  PGLTTKLLSG  HVDRVMVGFE  ESREAYGAVG  SVTVTGTPVR  GAFADYSKSK180
AKAELGLDPD  KPLVLSVWGS  LGAGHMNEIV  SQMLPLMRGQ  QDFYFIHSAG  KRYYEGMMET240
LGDPEKLKSD  CGADIREYIY  DMPRVMAAAD  LILCRAGAST  ISELTFLGKP  TVFVPSPNVT300
NNHQEKNARV  LEKAGGAKVL  LEGEFDAQSL  LDTVKALLSD  SAALESMAKA  MSSLAVTDAT360
DRICGVILDM  LNK373

Enzyme Prediction      help

No EC number prediction in MGYG000001947_00093.

CAZyme Signature Domains help

Created with Snap1837557493111130149167186205223242261279298317335354194359GT28
Family Start End Evalue family coverage
GT28 194 359 3.4e-46 0.9872611464968153

CDD Domains      download full data without filtering help

Created with Snap18375574931111301491671862052232422612792983173353541373murG3364GT28_MurG1373MurG1363murG199363Glyco_tran_28_C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 1.90e-137 1 373 2 357
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 4.77e-130 3 364 2 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 1.65e-108 1 373 1 357
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 5.25e-100 1 363 1 344
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam04101 Glyco_tran_28_C 8.40e-39 199 363 7 166
Glycosyltransferase family 28 C-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.

CAZyme Hits      help

Created with Snap18375574931111301491671862052232422612792983173353541373QIA29973.1|GT281373QQR06670.1|GT281373ANU40556.1|GT281368QNL43650.1|GT281363BCK80743.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
QIA29973.1 1.80e-124 1 373 1 372
QQR06670.1 1.67e-122 1 373 1 372
ANU40556.1 1.67e-122 1 373 1 372
QNL43650.1 2.22e-122 1 368 1 369
BCK80743.1 9.92e-121 1 363 1 363

PDB Hits      download full data without filtering help

Created with Snap183755749311113014916718620522324226127929831733535423703S2U_A43631F0K_A43707D1I_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 1.77e-45 2 370 4 354
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
1F0K_A 2.53e-44 4 363 10 346
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
7D1I_A 1.54e-40 4 370 13 365
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18375574931111301491671862052232422612792983173353541373sp|A3DE27|MURG_ACET21363sp|Q8R9G6|MURG_CALS41363sp|B0K3H0|MURG_THEPX1363sp|B0K8K7|MURG_THEP31372sp|B7GGI2|MURG_ANOFW
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A3DE27 1.61e-101 1 373 1 365
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=murG PE=3 SV=1
Q8R9G6 6.34e-86 1 363 1 356
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) OX=273068 GN=murG PE=3 SV=1
B0K3H0 4.03e-84 1 363 1 356
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter sp. (strain X514) OX=399726 GN=murG PE=3 SV=1
B0K8K7 4.03e-84 1 363 1 356
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=murG PE=3 SV=1
B7GGI2 1.10e-83 1 372 1 363
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Anoxybacillus flavithermus (strain DSM 21510 / WK1) OX=491915 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000040 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001947_00093.