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CAZyme Information: MGYG000002710_00499

You are here: Home > Sequence: MGYG000002710_00499

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species CAG-170 sp900549635
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Oscillospiraceae; CAG-170; CAG-170 sp900549635
CAZyme ID MGYG000002710_00499
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
375 MGYG000002710_3|CGC1 41501.76 7.8994
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002710 2272062 MAG Canada North America
Gene Location Start: 56782;  End: 57909  Strand: -

Full Sequence      Download help

MNIVFTCGGT  GGHIYPAIAV  ARLFEQRQPG  CNILFIGAED  GMENKIVPRE  GFRLETLKIS60
NFQRKLTPSA  IAHNIETAAH  LTESRRKVHR  ILTEFRPDIV  IGTGGYASFP  ALREGARLSI120
PTMVHESNAV  PGLTTRMVEK  YMDRIMVSFE  DSRSSYHDPN  KVVVTGTPVR  EEFLYTRRQA180
AREKLGLDER  PFIVSCWGSL  GAREMNKKIA  EFMKCEAEAG  EPFQHLHATG  SFGWRWMPQY240
VKDLGLDLSK  HPAIDMREYI  FNMPTAMAAA  DLIICRAGAA  TISEVCASAL  PCIMVPSPNV300
TNNHQEKNAM  VLQGRGAAVV  VPEAGCSGKL  LFDTAREILA  DTERTKSMRQ  AASSLAVVDS360
AQRIYETALE  LIQSR375

Enzyme Prediction      help

No EC number prediction in MGYG000002710_00499.

CAZyme Signature Domains help

Created with Snap1837567593112131150168187206225243262281300318337356198357GT28
Family Start End Evalue family coverage
GT28 198 357 9.1e-41 0.9363057324840764

CDD Domains      download full data without filtering help

Created with Snap18375675931121311501681872062252432622813003183373561374murG3366GT28_MurG1372MurG1368murG3147Glyco_transf_28
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 1.25e-115 1 374 2 357
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 1.66e-113 3 366 2 349
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 3.28e-96 1 372 1 355
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 6.05e-87 1 368 1 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam03033 Glyco_transf_28 2.83e-33 3 147 1 139
Glycosyltransferase family 28 N-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.

CAZyme Hits      help

Created with Snap18375675931121311501681872062252432622813003183373561373ALP93424.1|GT281373QBB66432.1|GT281375QIA29973.1|GT281373QNL43650.1|GT281375QQR06670.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
ALP93424.1 9.61e-137 1 373 1 373
QBB66432.1 5.51e-136 1 373 1 373
QIA29973.1 5.51e-134 1 375 1 373
QNL43650.1 1.03e-133 1 373 1 373
QQR06670.1 8.99e-133 1 375 1 373

PDB Hits      download full data without filtering help

Created with Snap183756759311213115016818720622524326228130031833735623713S2U_A23641F0K_A23647D1I_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 1.26e-46 2 371 4 354
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
1F0K_A 1.62e-39 2 364 8 346
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
7D1I_A 3.31e-37 2 364 11 365
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18375675931121311501681872062252432622813003183373561375sp|A3DE27|MURG_ACET21366sp|Q8R9G6|MURG_CALS41366sp|B0K3H0|MURG_THEPX1366sp|B0K8K7|MURG_THEP31372sp|B7GGI2|MURG_ANOFW
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A3DE27 1.34e-92 1 375 1 366
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=murG PE=3 SV=1
Q8R9G6 2.70e-85 1 366 1 358
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) OX=273068 GN=murG PE=3 SV=1
B0K3H0 3.04e-84 1 366 1 358
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter sp. (strain X514) OX=399726 GN=murG PE=3 SV=1
B0K8K7 3.04e-84 1 366 1 358
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=murG PE=3 SV=1
B7GGI2 1.87e-82 1 372 1 362
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Anoxybacillus flavithermus (strain DSM 21510 / WK1) OX=491915 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000032 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002710_00499.