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CAZyme Information: MGYG000003084_00049

You are here: Home > Sequence: MGYG000003084_00049

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species CAG-724 sp900551005
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; CAG-272; CAG-724; CAG-724 sp900551005
CAZyme ID MGYG000003084_00049
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
379 MGYG000003084_1|CGC1 41923.92 8.7703
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003084 1926204 MAG Spain Europe
Gene Location Start: 47488;  End: 48627  Strand: +

Full Sequence      Download help

MKVLLSGGGT  AGHVNPALAI  ADLIKAHDKR  AEIAFVGTKK  GIENRLCEKA  GYPIYHIEVK60
GLKRSLSLSN  IKTAYYYFTA  PKKAKKLLLE  YKPDIVIGTG  GFVCWPLLSA  ATKLGIPTAL120
HESNAIPGKA  VKMLADKVDR  IYVNFASTME  YFADKSKVLF  VGNPMMQKST  AKIPENIREI180
LNIPEGTEKI  LLSFGGSLGA  ARLNSEIIAL  MKNFSSVHPE  VFHIHATGSS  SHEETVAAFR240
AAGLEDCRNL  RLTEYIYDMP  YWERLSDAVI  CRAGAMTVSE  MALQKKACIL  IPSPNVANNH300
QYENAKRLAD  ANAAIMIEEK  HLCTDMLEKC  VCDILYDREK  ASAMRENIAA  FAKTDANELI360
WRDIKILLSR  DIMKLLESK379

Enzyme Prediction      help

No EC number prediction in MGYG000003084_00049.

CAZyme Signature Domains help

Created with Snap1837567594113132151170189208227246265284303322341360191356GT28
Family Start End Evalue family coverage
GT28 191 356 1.6e-41 0.9872611464968153

CDD Domains      download full data without filtering help

Created with Snap18375675941131321511701892082272462652843033223413602360GT28_MurG1360murG1360MurG1360murG3143Glyco_transf_28
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd03785 GT28_MurG 4.38e-115 2 360 1 347
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
PRK00726 murG 1.21e-114 1 360 2 347
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
COG0707 MurG 6.32e-89 1 360 1 347
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 2.85e-86 1 360 1 344
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam03033 Glyco_transf_28 1.01e-38 3 143 1 139
Glycosyltransferase family 28 N-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.

CAZyme Hits      help

Created with Snap18375675941131321511701892082272462652843033223413601364QIB70094.1|GT281374ADU74308.1|GT281374ABN52206.1|GT281374ANV75998.1|GT281374ALX08250.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
QIB70094.1 1.23e-89 1 364 1 362
ADU74308.1 3.14e-88 1 374 1 364
ABN52206.1 3.14e-88 1 374 1 364
ANV75998.1 3.14e-88 1 374 1 364
ALX08250.1 3.14e-88 1 374 1 364

PDB Hits      download full data without filtering help

Created with Snap183756759411313215117018920822724626528430332234136023603S2U_A33587D1I_A23641F0K_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 1.23e-41 2 360 4 347
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
7D1I_A 9.08e-41 3 358 12 356
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
1F0K_A 1.32e-37 2 364 8 350
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18375675941131321511701892082272462652843033223413601374sp|A3DE27|MURG_ACET21365sp|B8I6H3|MURG_RUMCH1365sp|B0K3H0|MURG_THEPX1365sp|B0K8K7|MURG_THEP31364sp|A6TS61|MURG_ALKMQ
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A3DE27 6.27e-89 1 374 1 364
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=murG PE=3 SV=1
B8I6H3 6.95e-81 1 365 1 361
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) OX=394503 GN=murG PE=3 SV=1
B0K3H0 3.91e-80 1 365 1 361
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter sp. (strain X514) OX=399726 GN=murG PE=3 SV=1
B0K8K7 3.91e-80 1 365 1 361
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=murG PE=3 SV=1
A6TS61 2.61e-78 1 364 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Alkaliphilus metalliredigens (strain QYMF) OX=293826 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000051 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003084_00049.