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CAZyme Information: MGYG000004046_00211

You are here: Home > Sequence: MGYG000004046_00211

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Limosilactobacillus vaginalis
Lineage Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Limosilactobacillus; Limosilactobacillus vaginalis
CAZyme ID MGYG000004046_00211
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
366 MGYG000004046_3|CGC1 40012.48 10.3236
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000004046 1731903 MAG United Kingdom Europe
Gene Location Start: 7248;  End: 8348  Strand: +

Full Sequence      Download help

MRLLVSGGGT  GGHIYPALAL  IERLKQVEPD  TEVLYVGTTR  GLENKIVPDA  GIKLETMHMQ60
GFKRSLSLEN  FKTVYLFLRS  VHHAKKIIRD  FKPDVVLGTG  GYVSGAVLYA  AAKQHIPTVI120
HEQNSVVGVT  NKFLSRYVDQ  IAIAFEAARN  QFPEGKVTMT  GNPRAQQVAS  QTASTFSWKE180
YGLEDDVPTL  MVFGGSQGAP  KINTTVVDAI  PKFNKRPYQV  ILATGQKRYD  NVKKQLQGVK240
IGKNVKVVPY  IKDMPAKMPK  VAALVSRAGA  TTIAEVTALG  VPTILIPSPY  VTANHQVKNA300
QSLVRKNAAV  MITEDKLDSR  SLLLQADKIM  ENKDLRAKMA  DASRKIGHPQ  AADELIAVLH360
KAINEH366

Enzyme Prediction      help

No EC number prediction in MGYG000004046_00211.

CAZyme Signature Domains help

Created with Snap1836547391109128146164183201219237256274292311329347189351GT28
Family Start End Evalue family coverage
GT28 189 351 1.3e-49 0.9936305732484076

CDD Domains      download full data without filtering help

Created with Snap18365473911091281461641832012192372562742923113293471363murG2358GT28_MurG1365MurG1359murG3143Glyco_transf_28
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 1.64e-155 1 363 2 355
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 1.06e-145 2 358 1 350
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 1.28e-113 1 365 1 357
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 1.14e-108 1 359 1 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam03033 Glyco_transf_28 7.65e-47 3 143 1 139
Glycosyltransferase family 28 N-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.

CAZyme Hits      help

Created with Snap18365473911091281461641832012192372562742923113293471366QFS33924.1|GT281366QFG72396.1|GT281366QZN93703.1|GT281366QFV00768.1|GT281366AMS07946.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
QFS33924.1 8.03e-256 1 366 1 366
QFG72396.1 3.14e-226 1 366 1 366
QZN93703.1 9.00e-226 1 366 1 366
QFV00768.1 1.01e-224 1 366 1 366
AMS07946.1 1.60e-221 1 366 1 366

PDB Hits      download full data without filtering help

Created with Snap183654739110912814616418320121923725627429231132934723563S2U_A23617D1I_A23171F0K_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 3.86e-46 2 356 4 348
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
7D1I_A 3.86e-46 2 361 11 364
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
1F0K_A 5.23e-35 2 317 8 310
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18365473911091281461641832012192372562742923113293471366sp|A5VJ33|MURG_LIMRD1366sp|B2G6K5|MURG_LIMRJ1366sp|B2GB78|MURG_LIMF31359sp|Q03QH5|MURG_LEVBA1365sp|Q1WTA0|MURG_LIGS1
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A5VJ33 1.69e-220 1 366 1 368
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Limosilactobacillus reuteri (strain DSM 20016) OX=557436 GN=murG PE=3 SV=1
B2G6K5 1.69e-220 1 366 1 368
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Limosilactobacillus reuteri (strain JCM 1112) OX=557433 GN=murG PE=3 SV=1
B2GB78 3.97e-193 1 366 1 366
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251) OX=334390 GN=murG PE=3 SV=1
Q03QH5 5.63e-159 1 359 1 358
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) OX=387344 GN=murG PE=3 SV=1
Q1WTA0 8.53e-154 1 365 1 365
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Ligilactobacillus salivarius (strain UCC118) OX=362948 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000065 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000004046_00211.