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CAZyme Information: MGYG000004099_00067

You are here: Home > Sequence: MGYG000004099_00067

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Eubacterium_R sp000433975
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Acutalibacteraceae; Eubacterium_R; Eubacterium_R sp000433975
CAZyme ID MGYG000004099_00067
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
372 MGYG000004099_1|CGC2 39939.02 7.1506
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000004099 1856381 MAG United Kingdom Europe
Gene Location Start: 65354;  End: 66472  Strand: +

Full Sequence      Download help

MKILFATGGT  AGHINPALAV  ASYIRENYPE  TQILFIGTAD  HMEARLVPNA  GFDFKTIEIS60
GFRRSLSPSA  ISHNIKTVSQ  LIKSESKSKK  IIKEFSPDVC  VGFGGYVSGP  VLEKAAALGI120
PICVHEQNAF  PGITNKALAK  KADKVMITVA  DAAGRLECKN  EPIVTGLPVR  GEILRANRDF180
ARAELGVGDK  PLVLSFGGSL  GAAPINEAMF  EILLNSAESG  KYYHIHSVGT  NGGEYLEKFE240
KAGFVNGKKG  TVEVRQYIDN  MDICMAAADL  VIGRAGASSL  SEIEALGKAS  ILIPSPYVAE300
NHQYHNAMAL  VRRNAARIIE  EKELTSERLK  TVIDEVLGNP  QELAEIEKNA  KSMAVTDSAK360
IIADIIMEAA  KK372

Enzyme Prediction      help

No EC number prediction in MGYG000004099_00067.

CAZyme Signature Domains help

Created with Snap1837557493111130148167186204223241260279297316334353193357GT28
Family Start End Evalue family coverage
GT28 193 357 6.5e-47 0.9808917197452229

CDD Domains      download full data without filtering help

Created with Snap18375574931111301481671862042232412602792973163343531372murG2365GT28_MurG1372MurG1366murG3147Glyco_transf_28
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 1.49e-135 1 372 2 357
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 1.37e-128 2 365 1 350
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 8.56e-100 1 372 1 357
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 3.39e-99 1 366 1 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam03033 Glyco_transf_28 7.18e-39 3 147 1 139
Glycosyltransferase family 28 N-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.

CAZyme Hits      help

Created with Snap18375574931111301481671862042232412602792973163343531366QCT06982.1|GT281368QEY33586.1|GT281369ANU55131.1|GT281369QQR30895.1|GT281369ASB41635.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
QCT06982.1 3.25e-136 1 366 1 366
QEY33586.1 8.66e-132 1 368 1 368
ANU55131.1 3.74e-131 1 369 1 369
QQR30895.1 3.74e-131 1 369 1 369
ASB41635.1 3.74e-131 1 369 1 369

PDB Hits      download full data without filtering help

Created with Snap183755749311113014816718620422324126027929731633435323713S2U_A23711F0K_A33687D1I_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 1.82e-50 2 371 4 356
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
1F0K_A 3.94e-48 2 371 8 355
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
7D1I_A 1.08e-40 3 368 12 364
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18375574931111301481671862042232412602792973163343531371sp|A3DE27|MURG_ACET21366sp|B0K8K7|MURG_THEP31366sp|B0K3H0|MURG_THEPX1366sp|A4J2B1|MURG_DESRM1372sp|A7GRN6|MURG_BACCN
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A3DE27 4.17e-96 1 371 1 364
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=murG PE=3 SV=1
B0K8K7 3.07e-86 1 366 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=murG PE=3 SV=1
B0K3H0 3.07e-86 1 366 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter sp. (strain X514) OX=399726 GN=murG PE=3 SV=1
A4J2B1 5.53e-86 1 366 1 368
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Desulfotomaculum reducens (strain MI-1) OX=349161 GN=murG PE=3 SV=1
A7GRN6 6.13e-86 1 372 1 364
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) OX=315749 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000057 0.000002 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000004099_00067.