logo
sublogo
You are browsing environment: HUMAN GUT
help

CAZyme Information: MGYG000004546_00329

You are here: Home > Sequence: MGYG000004546_00329

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species CAG-460 sp900751815
Lineage Bacteria; Firmicutes; Bacilli; RF39; UBA660; CAG-460; CAG-460 sp900751815
CAZyme ID MGYG000004546_00329
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
359 40536.67 9.8566
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000004546 1057207 MAG France Europe
Gene Location Start: 342;  End: 1421  Strand: +

Full Sequence      Download help

MKIIISAGGT  GGHIYPALAI  LKKFQEKEKN  LEVIYIGTHD  RMEKDIIPNM  GIKYIPLEIY60
GFSKKKLFRD  FKNIFLIRKA  MKKCLKIMEE  FKPDVVIGAG  GYVTYPVIRA  AHKLGIKTFI120
HEQNSVAGKS  NITLAKYVDL  VGVSFKNSED  YFKTAKKVVY  TGNPCGENAL  VAKKIPKSTY180
GFKESDKLII  IVAGSQGSSS  LNEKFQAFLK  LVENEEYKVL  YITGKNLYDD  FIKDNVFPKN240
VKVVPYVDNL  AGLMKNAYLI  ISRAGASTIS  EILALKIPSI  LIPSPYVANN  HQYYNALDLV300
NMKVAELIEE  KRLDANLIQV  TINEIINTKK  YAEMKRNLEK  LNIKEASTII  YEEIKELLK359

Enzyme Prediction      help

No EC number prediction in MGYG000004546_00329.

CAZyme Signature Domains help

Created with Snap1735537189107125143161179197215233251269287305323341189345GT28
Family Start End Evalue family coverage
GT28 189 345 5.3e-42 0.9808917197452229

CDD Domains      download full data without filtering help

Created with Snap17355371891071251431611791972152332512692873053233411359murG2353GT28_MurG1359MurG1354murG3143Glyco_transf_28
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 1.29e-125 1 359 2 356
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 2.66e-123 2 353 1 350
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 4.08e-100 1 359 1 356
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 1.44e-97 1 354 1 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam03033 Glyco_transf_28 2.47e-44 3 143 1 139
Glycosyltransferase family 28 N-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.

CAZyme Hits      help

Created with Snap17355371891071251431611791972152332512692873053233411359QOY34376.1|GT281359AKO93922.1|GT281357AKP46770.1|GT281347QCX25967.1|GT281358AYC10220.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
QOY34376.1 2.86e-93 1 359 1 363
AKO93922.1 5.90e-90 1 359 1 363
AKP46770.1 3.90e-89 1 357 1 361
QCX25967.1 1.04e-88 1 347 1 353
AYC10220.1 4.02e-88 1 358 1 363

PDB Hits      download full data without filtering help

Created with Snap173553718910712514316117919721523325126928730532334133347D1I_A23221F0K_A23403S2U_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
7D1I_A 9.31e-45 3 334 12 342
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
1F0K_A 3.66e-43 2 322 8 319
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
3S2U_A 5.84e-40 2 340 4 340
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]

Swiss-Prot Hits      download full data without filtering help

Created with Snap17355371891071251431611791972152332512692873053233411358sp|Q1WTA0|MURG_LIGS11358sp|O07670|MURG_ENTHR1359sp|A7GRN6|MURG_BACCN1357sp|Q65JY0|MURG_BACLD1357sp|Q8R9G6|MURG_CALS4
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q1WTA0 4.55e-88 1 358 1 363
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Ligilactobacillus salivarius (strain UCC118) OX=362948 GN=murG PE=3 SV=1
O07670 7.05e-86 1 358 1 358
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Enterococcus hirae OX=1354 GN=murG PE=3 SV=1
A7GRN6 7.97e-86 1 359 1 363
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) OX=315749 GN=murG PE=3 SV=1
Q65JY0 4.78e-85 1 357 1 361
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) OX=279010 GN=murG PE=3 SV=1
Q8R9G6 1.80e-84 1 357 1 363
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) OX=273068 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000066 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000004546_00329.