CAZyme Information: MGYG000000234_00542

Basic Information

• Species: Vagococcus teuberi
• Lineage: Bacteria; Firmicutes; Bacilli; Lactobacillales; Vagococcaceae; Vagococcus; Vagococcus teuberi
• CAZyme ID: MGYG000000234_00542
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
758		84849.72	5.8733

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000234	2257969	Isolate	China	Asia

• Gene Location: Start: 560843; End: 563119 Strand: +

Full Sequence      

MKNSSIGTKHPNKSSKQKKHNTKKVVLITLTVILSLIIIPLIGGAGLFFYYAKDAPTLDY
KKLEDTRSSKIYASNGEMILEIGEKKRETIEPNQIPPTLKQAIISIEDKRFEKHAGIDPI
RIVGAAISNIKGTSRQGGSTLTQQLIKLSFFSTKKEDQTIKRKAQEAWLSVELERKKSKD
EILTYYINRVYMANGIYGMQTAAETYFGKNLGDLSLAQYALLAGMPQAPIDYDPYTHPDL
ATTRRNLVLSEMYKDKVISKKDYDEAKNTKIEDGLISLKEDSTTQVVTDNYVKQVIDEVQ
KKTKKNVYTDGLDIYTNMDLAAQTYLYNLINSENSSIAFPDEKFQATATLIDVKNGDVRA
QIGGRNVGDGAMNDNKAVTAKRNIGSTAKPLVAYAPTIEDLNYGSGQIYADMPYKYEDGT
PVYDYDRSYRGNLTMRESLVDSRNIPALKALKEIGDDKSKEFISKLGLDNNVYEGTAIGF
ESSSEKLAAAYAAFANGGIYYEPSYVNKVVYSDGTEESFESQGKRAMKESTAFIVTDMLK
DVINRGTGNQAQIDGIVQAGKTGTSNYDDDVLGKVKGEGSPDITFVGYTPKYSLAVWTGY
DDYFQPITLYNQQLAMDIYRSFMMYLYQNIEPTDWKQPSNVVRVGNEVYIKGHTKQTQSL
YNSPKSDNTTYYYETEKQTVTPHSESKEETKEDTHTETSKETSVEEKKPDTNNSQTNQSS
NNNEQTNLGNNSNNQTNQGNNNSPTQENKPRNNDTKKD

Enzyme Prediction     

EC	2.4.1.129

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	76	253	9.1e-63	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	0.0	86	629	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	4.83e-177	43	687	30	654	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	6.97e-111	43	644	22	736	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.45e-89	57	645	125	699	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam00912	Transgly	1.01e-79	75	253	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
APB31618.1	0.0	1	758	1	758
QNN72185.1	0.0	39	682	33	671
QIL48981.1	0.0	39	666	35	667
AQP54460.1	4.31e-302	39	677	29	661
QZN89028.1	2.95e-248	13	669	15	676

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2ZC5_B	9.43e-98	289	652	10	388	ChainB, Penicillin-binding protein 1A [unidentified],2ZC5_D Chain D, Penicillin-binding protein 1A [unidentified],2ZC6_B Chain B, Penicillin-binding protein 1A [unidentified],2ZC6_D Chain D, Penicillin-binding protein 1A [unidentified]
2V2F_F	1.32e-97	289	652	10	388	Crystalstructure of PBP1a from drug-resistant strain 5204 from Streptococcus pneumoniae [Streptococcus pneumoniae]
2C6W_B	4.27e-97	289	649	7	382	Penicillin-BindingProtein 1a (Pbp-1a) From Streptococcus Pneumoniae [Streptococcus pneumoniae]
2C5W_B	6.18e-97	289	649	8	383	PENICILLIN-BINDINGPROTEIN 1A (PBP-1A) ACYL-ENZYME COMPLEX (CEFOTAXIME) FROM STREPTOCOCCUS PNEUMONIAE [Streptococcus pneumoniae R6]
3DWK_A	9.11e-91	63	641	2	602	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q04707	2.15e-198	41	664	25	659	Penicillin-binding protein 1A OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=ponA PE=1 SV=2
Q8DR59	6.87e-197	41	664	25	659	Penicillin-binding protein 1A OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=pbpA PE=1 SV=1
Q00573	3.46e-192	44	635	28	635	Penicillin-binding protein 1A (Fragment) OS=Streptococcus oralis OX=1303 GN=ponA PE=3 SV=1
P39793	4.72e-134	41	599	49	613	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1
P38050	1.19e-83	58	601	38	571	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.961383	0.035889	0.000286	0.000211	0.000101	0.002140

TMHMM  Annotations     

start	end
26	48