CAZyme Information: MGYG000000356_00374

Basic Information

• Lineage: Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; VUNI01
• CAZyme ID: MGYG000000356_00374
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
791	MGYG000000356_3|CGC1	87846.73	4.2426

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000356	2991584	MAG	Sweden	Europe

• Gene Location: Start: 19398; End: 21773 Strand: -

Full Sequence      

MAKKKKRKKQHRFFWFMVKLQIVLMLLVLGGLGYYYFGGYAVEVQELKKEAVQLVSQSDD
ETFIPAKTCSIYDVNGNLISETNGDKDAVYVKYEDIPADFVTAMISIEDKKFYQHNGVDY
KAILRAVKAALEKGEASQGGSTVTMQLAKLVYLDSSKTWERKVEQIFVALELEKRYSKNK
IMEFYLNNIYFANGYYGIEAACKGYFNCELSDLDISQIAFLCAIPNSPTYYDPVANIEHT
LKRRNLILKNMYEDGKISESAYNSAVSEQIALNRPQETEEQRNNYVDTYTYYCATRALMQ
NEGFEFQYYFDNEDAEKTYDDLYDEMYAECQKKIYSGGYKIYTSIDLEKQADLQSAVDST
LASFTETGDDGIYTLQGSAVCIDNDTGLVAAIVGGRSQDFTTYTLNRAYQSFRQPGSCIK
PVIDYTPAFERGYTPDSVVKDEPIENGPQNASKTYQGDVTIRYAVEQSLNTVAWKLYEEI
TPEAGLQYLKNMNFSQIQPADNTPATSIGGFTIGMSTLEMASAYATIENDGVYREPTCVK
SISDSTDQVVYTLEPKETVIYKETASRMMTDVLKSVMTNGLGRKMQLTNMISAGKTGTTN
DNKDGWFCGYTRYYTTAVWVGYDIPQEVPGLAGGSYPGQIWQTYMNQIHEGKTSVDFLPY
AQLSDEFKSQNSDQGSDDGNADQPAEGQDQGAGDAAGQDPNAGAGDVAGQDPNAGTGDQQ
NPDPNAGQDPNAGQDQNQNTGTGDQQSQNQTTDQNSNNGNNNPQTNDQNQNDGNQQNPNA
GQDQGNAAPQN

Enzyme Prediction     

No EC number prediction in MGYG000000356_00374.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	76	252	1.8e-63	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	1.56e-179	87	651	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.97e-164	71	733	58	660	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	5.32e-136	65	659	45	729	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
COG4953	PbpC	2.70e-80	71	659	39	573	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	7.76e-79	75	252	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
CBK89800.1	5.46e-312	31	684	33	686
ACR76878.1	1.61e-311	31	684	33	689
CBK93334.1	3.85e-311	31	684	33	689
CBL14325.1	4.39e-282	31	666	19	652
CBL07484.1	5.02e-280	37	685	37	685

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	1.84e-73	67	651	19	718	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	3.82e-72	64	645	19	719	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
7U4H_A	3.44e-69	49	657	3	769	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
3ZG8_B	9.47e-67	171	657	2	469	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3DWK_A	4.87e-62	64	680	6	618	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P40750	6.98e-99	43	642	30	617	Penicillin-binding protein 4 OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpD PE=1 SV=2
O66874	3.04e-83	61	657	37	676	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
Q8XJ01	4.12e-82	46	650	59	667	Penicillin-binding protein 1A OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=pbpA PE=3 SV=1
P38050	8.75e-82	59	650	39	599	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
P39793	1.77e-81	70	621	78	613	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999855	0.000037	0.000004	0.000000	0.000000	0.000147

TMHMM  Annotations     

start	end
13	35