CAZyme Information: MGYG000001054_00043

Basic Information

• Species: Succinivibrio sp900555115
• Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Succinivibrionaceae; Succinivibrio; Succinivibrio sp900555115
• CAZyme ID: MGYG000001054_00043
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
840		92716.01	6.7923

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001054	2025835	MAG	Spain	Europe

• Gene Location: Start: 32077; End: 34599 Strand: +

Full Sequence      

MGKMLFSEKNVIFRIVRNTLWAGLFLGAVSSAAAAGLYYNALGSLPDVSELKTVSFEIPM
QIFTKDGKLIGEFGEAKRIPVPLNEIPLKLRQAFLAIEDSRFYEHSGIDPIGIARAAFVA
LANAGNAKQGASTITQQVARNFFLTRKKTLKRKVREVFISLRIEQVLTKDEIFELYLNKI
ALGHNSYGVAAAAQVYYGKELKDLTLAEMATIAGLPKAPSSLNPVSNPERSRDRRNTVLG
RMLSLGYITKAEFEEASHAPYRTFVHGAPLEAYAPYVAENARQFAIDQYGDKAYTEGFKV
YTTVDSKIQTDAHYAVFKGVTAYDTRHGYRGPVARLSELPDYRDTEIEREKLLRSYDKYH
FIAPAIVESTDDHKKTAAILMRGNAHETLLWEAMKWAAPFRSDRSRGPAPKKPSEILKKG
DIVYVYRDEQRVLQLTQLPQVESALVAINPYTGGIEALVGGYDFEKSKFDRTTMAKRQVG
SNFKPFLYSSAIARGLSINSLFMDEPLKTWDPGSRTWWEPKNTPNRYDGIMTLREALARS
KNVVSVRLIRQIGVPNAVTHVQKFGFEIPRSQQVESMALGSVEVTPLELCTGYAVFANGG
YKLLPHLISRIERNGEVVYAADVRKADPNAPDRVINDIELKFDEEIPEDPHMAPQVLSHG
NAFIVADMMRSVIYGGEGMTGPYWGTGGRAQAITGRKDLHGKTGTTNDVHDAWFSGFNAS
VVATAWMGFDTDRDLGYSAQGPEGGAYSALPVWGEFIKRSQKGVAQDDLPKPADVFKCSN
EGISDYCLKGASAVTQVPQGELEEGASNDATQNNEAGSASSDGKEEPVNSAPGEDPEDIF

Enzyme Prediction     

No EC number prediction in MGYG000001054_00043.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	66	242	1.3e-68	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK11636	mrcA	0.0	45	775	33	799	penicillin-binding protein 1a; Provisional
TIGR02074	PBP_1a_fam	0.0	77	758	1	526	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	0.0	45	773	34	731	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
COG0744	MrcB	7.58e-164	14	824	10	661	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	3.00e-88	66	243	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ACQ94216.1	5.35e-240	16	792	5	793
AEY02747.1	3.60e-226	25	791	14	769
ALQ09409.1	2.40e-223	15	775	3	779
QFI55800.1	2.89e-223	20	800	9	795
ATG76388.1	6.79e-223	15	775	3	779

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	3.89e-183	48	803	9	760	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5U2G_A	2.02e-172	40	775	2	772	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
3UDF_A	2.13e-167	59	763	20	718	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3NB6_A	2.42e-54	67	256	9	197	Crystalstructure of Aquifex aeolicus peptidoglycan glycosyltransferase in complex with Methylphosphoryl Neryl Moenomycin [Aquifex aeolicus]
2OQO_A	3.33e-54	67	256	9	197	Crystalstructure of a peptidoglycan glycosyltransferase from a class A PBP: insight into bacterial cell wall synthesis [Aquifex aeolicus VF5],3D3H_A Crystal structure of a complex of the peptidoglycan glycosyltransferase domain from Aquifex aeolicus and neryl moenomycin A [Aquifex aeolicus],3NB7_A Crystal structure of Aquifex Aeolicus Peptidoglycan Glycosyltransferase in complex with Decarboxylated Neryl Moenomycin [Aquifex aeolicus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q9KNU5	1.42e-209	36	775	24	772	Penicillin-binding protein 1A OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mrcA PE=3 SV=2
P02918	9.92e-205	36	775	24	799	Penicillin-binding protein 1A OS=Escherichia coli (strain K12) OX=83333 GN=mrcA PE=1 SV=1
Q07806	8.85e-186	14	803	2	787	Penicillin-binding protein 1A OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=mrcA PE=1 SV=2
P31776	2.79e-173	12	804	3	825	Penicillin-binding protein 1A OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) OX=71421 GN=mrcA PE=1 SV=2
Q87AW7	1.02e-156	24	792	16	778	Penicillin-binding protein 1A OS=Xylella fastidiosa (strain Temecula1 / ATCC 700964) OX=183190 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.947914	0.048594	0.000864	0.000371	0.000195	0.002075

TMHMM  Annotations     

start	end
20	42