CAZyme Information: MGYG000001148_00304

Basic Information

• Species: Fusobacterium_A varium_A
• Lineage: Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae; Fusobacterium_A; Fusobacterium_A varium_A
• CAZyme ID: MGYG000001148_00304
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
723	MGYG000001148_33|CGC1	81442.73	9.3271

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001148	3218254	MAG	China	Asia

• Gene Location: Start: 3280; End: 5451 Strand: -

Full Sequence      

MKILVKRIIKIMIVLFIVGSIASVGVVLGVINKYSKELPDIVTLIEDYAPSLPTVLYDRN
GEVIDTIYRESRDTVKLKEVPIYSRNAFLAIEDKQFYSHHGIHIKRLIGAIVANIRSGRA
VQGASSITQQLAKNAFLSHERKLSRKIKEAIITFEIERRYTKDEIFEKYLNEIYFGAGSY
GIKTAAKQLYRKDISEINIAESALLAGIPNRPEKYNPRRNLEASLKRANLILSEMYKDKL
ITKEEYEQAKNHKFINEDKLPENFKMDDNTTIIYNKKSDVTINYPDFSNMVEEFLVDKFG
ENMVYTGGLRVHTTLDLEMQKTAKEVFENYEFFKKNDELQGGMATIDPNNGHVISLIGGR
NFKSGNFNRATMAKRQLGSSFKPFLYFTAIENGMEMNSVVEDSFISFGSWIPKNYGSRYS
NNVTLLNALDRSLNIVSIKMLQKIGTKTFKETVAKLDPSLNIPDDLTASLGSFENTPLQH
AIDYSIFSNGGYVVEPVTVTDVEDRYGNPIYQNTPKKEKVFDSINTSIITFMLKSSVQYG
SSSRASVYTKDKKRIEQGGKTGTVNDNRTIWFAGITPDYVTTIYIGYDDNRAIRGNVTGG
TGVAPLWAKYYQTLIDKGLYAPSTFSFLENHLKNGDFNLQTLTVNNGLISGAGREFLVRK
GKLQMESEMKYANGIAGIFGSVRKENGTEGTEGYNPVIEKTNNDIAPENTTSNDSLFKRL
LGN

Enzyme Prediction     

No EC number prediction in MGYG000001148_00304.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	61	236	5.2e-65	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	0.0	6	629	9	611	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	0.0	1	610	1	714	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	0.0	72	610	2	524	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
TIGR02071	PBP_1b	1.20e-126	49	615	132	683	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11636	mrcA	5.18e-103	7	616	2	786	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BBA51249.1	0.0	1	723	1	723
SQJ02489.1	0.0	1	723	1	723
AVQ29190.1	0.0	1	723	1	723
AVQ31939.1	0.0	1	723	1	723
VEH39205.1	0.0	1	723	1	723

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	1.88e-81	52	610	19	718	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	1.02e-75	53	610	20	711	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3DWK_A	2.26e-74	52	587	6	557	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
5U2G_A	2.30e-74	32	615	1	758	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
2OLU_A	7.53e-71	52	587	15	566	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	1.49e-101	1	614	1	667	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P0A0Z5	6.52e-97	23	612	20	703	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1
P0A0Z6	6.52e-97	23	612	20	703	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1
O87579	6.52e-97	16	612	19	703	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
Q5FAC7	9.10e-97	4	612	1	703	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) OX=242231 GN=mrcA PE=3 SV=3

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.950362	0.024010	0.004003	0.000176	0.000090	0.021375

TMHMM  Annotations     

start	end
12	31