CAZyme Information: MGYG000001159_00012

Basic Information

• Species: Bifidobacterium pullorum
• Lineage: Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Bifidobacteriaceae; Bifidobacterium; Bifidobacterium pullorum
• CAZyme ID: MGYG000001159_00012
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
767		82270.68	4.3247

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001159	2232439	MAG	Austria	Europe

• Gene Location: Start: 131; End: 2434 Strand: -

Full Sequence      

MVSQTRTAKRTPAARHFGGGIHRSHGSKGPKPKGKSKHLILKWVLGIIGALLALGIGAFA
YLYATTEIPQPESIAVAENTTVYYADGTTPIGTFSEQNREIIDCSVLPDYVGQAVVASED
RSFYTNRGIDLVGIARAFWNNLTTGSRQGGSTITQQYAERYYLGETTSYLGKAREAILAL
KIAQAQDKDQVLCNYMNTIYLGRGTYGIQAAAKAYFGKDAKDLTMPEAAMIAGIIPSPSS
WDPAVDPEQAQARFTRVLRIMQEDGYITAQEQQEVQFPQTIEYTQQNSYQGANGYLLQMV
RDELTGDGTFSAEQLDTGGYAIVTTIDKSKQDLMYSVVSPAQNGMQGVIPDGMEFGGISV
NAKDGSIISVYAGEDYLTKQLNQATQSVYEIGSTMKPMALLGAIQEGVNLDTVFNGNSPR
KFDGIADPVGNFGNMSYGNVNLYTATAQSLNTVYMDVQAKLGTQRIAEIAKEAGAESDAL
DGTNPFTVLGNNALTTKDVARMYVTIANQGNRPNIHIVSSVKNTDGEDIYKAPTETTQVF
DANDTALVTKAMTGTVQNGTATEALAVGHNLAMKTGTANDSYAASAVGFTPSVVSVFAMW
YPDANGNPQEVPAFGGWSGGSDYPVHLFTQYMTQALAGTDNETFPNAVDHGKVGGPDGSW
GLGSQTLQQMQGAQRKAEEEAQRQAEEEAQRQAEEEAQRQAEEEARRQQEQAEQERLEYC
QNNPNDVSCGGSGNTSGNTSGNEGAGEESGDGSEVEGGETDDDSEQS

Enzyme Prediction     

No EC number prediction in MGYG000001159_00012.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	89	262	6.4e-61	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	8.28e-131	45	645	18	606	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	1.28e-127	98	638	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	4.81e-108	40	644	4	727	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	4.70e-78	89	262	3	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
COG4953	PbpC	2.02e-47	46	616	2	546	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QAY33663.1	0.0	1	766	1	758
QTL79949.1	0.0	22	679	35	692
QTL78070.1	0.0	22	679	35	692
VEG22900.1	0.0	22	679	35	692
ADB08925.1	0.0	22	679	35	692

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5U2G_A	6.91e-40	64	532	3	566	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
5FGZ_A	4.59e-39	89	633	146	696	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	5.14e-39	89	633	167	717	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
3DWK_A	7.80e-39	97	648	25	602	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
3NB6_A	2.06e-38	92	274	13	196	Crystalstructure of Aquifex aeolicus peptidoglycan glycosyltransferase in complex with Methylphosphoryl Neryl Moenomycin [Aquifex aeolicus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P71707	2.37e-74	59	655	152	765	Penicillin-binding protein 1A OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=ponA1 PE=1 SV=3
A0R7G2	6.08e-72	34	655	61	703	Penicillin-binding protein 1A OS=Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) OX=246196 GN=ponA1 PE=3 SV=1
O66874	1.29e-59	42	644	3	676	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P0A0Z5	6.29e-59	40	638	5	708	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1
P0A0Z6	6.29e-59	40	638	5	708	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999730	0.000279	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
43	65