CAZyme Information: MGYG000001325_00997

Basic Information

• Species: Fusobacterium_C gonidiaformans
• Lineage: Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae; Fusobacterium_C; Fusobacterium_C gonidiaformans
• CAZyme ID: MGYG000001325_00997
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
711		79972.28	6.6854

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001325	1848478	Isolate	not provided	not provided

• Gene Location: Start: 20714; End: 22849 Strand: +

Full Sequence      

MKKIIKSLFLLSFLGVVGMGILVFSIVMKYKMELPDVQELVENYEVSAPSVIYDRNGEIV
DTLYQEARDNVKLEEVPEYSKQAFVAIEDKRFYEHHGIDPRGLLRAVFVNLRSGHARQGA
SSITQQLAKNAFLTMDRTLSRKIKEMIITIEIERVYTKDEILEKYLNEIYFGSGAYGLKT
AAKQFFHKDIQDINLAEAAMLAGVPNRPEGYNPRRKLENAIKRMNIVLSEMREDGKITEE
EYQEALKQKFISEKEASAKDKKNPKVTIIYPRKDTRHYENPEFTKLIEDFLLKKFDANTV
YNKGLKIYSSLDVAMQKSARTAFNQYPLLRARNGLNGAMVTIDPFSGQIITMVGGKDFKI
GNFNRAIMAKRQFGSSFKPFVYFAALLNGFESNSVLEDSPVTFGKWSPKNANGSFTNMNT
TLVNALDKSINSVSVKLLSAVGVPKFREMMEQVDPKLEIPDNLTAALGTAEGNPLQLAIN
YAMFVNGGYLVSPILVTSIEDKHGNLLYEVVPRKDKIFESQDTSIITYMLKSSVQSGTSA
RARVITRNGAPMEQGGKTGTTNNARTVWYAGITPEYVTTAYLGYDNNRAMPGLAGGNAVA
PLYHNYYQDIINKGLYTPGKFSFMEDHIKNGELVVQRLDILTGLLSSEGREFVIRRGHTV
VESDYKYLNGISSIFYGNPNPQEENADEHLEDGENPIVEEEEQLFDKLLGD

Enzyme Prediction     

No EC number prediction in MGYG000001325_00997.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	57	231	7.6e-70	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	0.0	1	629	8	615	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	0.0	68	606	2	524	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	3.39e-176	1	650	1	750	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.14e-123	65	608	144	680	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11636	mrcA	3.67e-108	3	588	2	747	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AVQ16916.1	0.0	1	711	1	711
AYV93001.1	0.0	1	711	1	712
AYZ74037.1	0.0	1	711	1	712
AZW10083.1	0.0	1	711	1	712
AVQ21317.1	0.0	1	711	1	712

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	1.45e-82	39	606	10	718	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5U2G_A	7.84e-79	31	649	4	788	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
3UDF_A	2.17e-77	42	606	13	711	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5FGZ_A	8.93e-64	77	606	165	689	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	1.21e-63	77	606	186	710	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	4.87e-98	1	606	1	663	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
O87579	4.82e-97	2	631	3	723	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
O87626	9.99e-95	2	606	3	700	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
Q5FAC7	1.94e-94	2	606	3	701	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) OX=242231 GN=mrcA PE=3 SV=3
O05131	1.94e-94	2	606	3	701	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae OX=485 GN=mrcA PE=1 SV=3

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999968	0.000047	0.000008	0.000000	0.000000	0.000014

TMHMM  Annotations     

start	end
7	28