CAZyme Information: MGYG000001608_00231

Basic Information

• Species: Gabonibacter sp900543425
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Marinifilaceae; Gabonibacter; Gabonibacter sp900543425
• CAZyme ID: MGYG000001608_00231
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
782		89881.2	9.6528

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001608	3329116	MAG	China	Asia

• Gene Location: Start: 262311; End: 264659 Strand: -

Full Sequence      

MSQRKVKRKAPTSKRKKSHSARFLKNIFLAILFCGMLLALFICCVYFGAWGKIPDYRDLR
EIRNYEASSLYSDDGELLGKYYIENRTNVMFDSISSYAINALIATEDVRFYEHHGFDKIS
MLRVVVKTLLLGDRSSGGGSTLSQQLAKNLFPREIKSRFMLPVIKVKEIITAHRLEKLYS
KDEILTLYLNTVSFGEDTFGIESAAQKYFSTTATHLTLLEAATLIGMLKGPTYYNPRLHP
ERALQRRNTVINQMVKYDYLTEEEGNFLKKEKLELEYRPINHYSGPAPYLRERIRQDAAR
IIQKYNETYGTSYDLYKDGLTITTTLDAEMQRYAEEAVQQHMKNLQNTFYTHWGKQDPWY
KDKTILDNAIRQSEIYQSLQQQGLSEKEILKEMGKKRPTIVYSTYQGETKMEISPIDSIK
HYLKFLHPGVIAVEPRSGKIKVWIGGLNFKYFQYDQVLAPRQVGSVFKPVIYSAAIRQGA
QIDAYYKNEQKSYPDYDDWTPRNSDNEYGGYYTLKGALSQSINTIAVEVLLQTGIENTIR
HARQLGITSDLPAVPSIALGTANIPLNEMILPYICYANNGIRVTPYYLQEIKDREGRLIY
KAPEPEKEEVMSAEEARLMSYMLSDVIREGTGRRLITNYGLNTAIAGKTGTTQNQADGWF
IGYNPRIVVGIRVGANNAQIHFNSIALGQGANMALPIFGLFMQECLKSNTYAYWGKTSFP
MPVLYKKEELEKPVFKDHMNILEKMTNHKIERITRNDTITPQKEKKGFFRRIGNLFKKKN
KN

Enzyme Prediction     

No EC number prediction in MGYG000001608_00231.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	74	255	1.3e-59	0.9943502824858758

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	1.52e-153	85	707	1	530	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	1.87e-152	22	707	3	720	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
COG0744	MrcB	6.88e-141	22	703	13	594	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	2.63e-88	70	679	139	661	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11636	mrcA	4.97e-85	33	706	3	785	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AZS28569.1	0.0	21	781	21	783
QRO48595.1	0.0	1	781	1	783
SNV29696.1	0.0	7	779	9	779
ADY31956.1	0.0	7	779	9	779
BAX81636.1	3.14e-253	2	780	14	797

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	1.45e-75	59	707	12	724	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	1.76e-64	70	714	23	723	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5U2G_A	3.54e-56	48	602	2	566	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
5FGZ_A	5.41e-48	84	679	154	672	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	6.53e-48	84	679	175	693	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	8.91e-90	24	698	1	660	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P0A0Z5	3.97e-83	50	707	32	707	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1
P0A0Z6	3.97e-83	50	707	32	707	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1
O87579	2.77e-81	48	707	30	707	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
O05131	1.02e-80	50	707	32	707	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae OX=485 GN=mrcA PE=1 SV=3

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000013	0.000021	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
28	50