CAZyme Information: MGYG000002406_00212

Basic Information

• Species: Corynebacterium pacaense
• Lineage: Bacteria; Actinobacteriota; Actinomycetia; Mycobacteriales; Mycobacteriaceae; Corynebacterium; Corynebacterium pacaense
• CAZyme ID: MGYG000002406_00212
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
721		76057.81	4.2139

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002406	3028764	Isolate	not provided	not provided

• Gene Location: Start: 187676; End: 189841 Strand: -

Full Sequence      

MTNKKNTSSKPARKQASKKKTVRNSIIAAIVAVIAIPALVFMTAYIVVDVPEPEELVSPQ
VSQIYAADGETELARVVPPEGNRQMVSLDKVPDAVSNAVLAAEDREFYTNPGFSITGYAR
AALGVITGDASAGGGSTITQQYVKKAVVGDERSIMRKAKEFVYSAKMANEWSKDEVLEAY
LNTVYFGRNAYGVQAASQAYFGKPVEELGPAEGAVLAASIQRPSELDPWTNPEEAKSRWA
YVLDGMVDIGAITEAERAQATYPDTVDPANNRAYTEASGTNGLIKNHVMAELSDVGITSE
DVETRGLQITTTIDPVAQQGAVDAVRDQLANQADNVRAALVSVDPGTGAVRAYYGGEDAA
GWDFANAPLQTGSTFKIFGLAAALQQGIPLSQVYSAAPVTVGNMVINNVPGFNCGACSIA
DALKYSHNTSFIRLQQDLENGPQDTADMAHALGIPRSLPGIPATLTENGATPYDGIILGQ
YESRVIDMATALATVADEGVWHETHFVQRVETISGEVLYEKEPSEGERRASAKVTENLLD
AMAPIAAYSNGNNLAGGRPSAAKTGTTQLGDTGNNKDAWMIGATPQLATAVWVGTEDNSP
LLTQWGGNMYGSNVPASIWKQTMDTALENDAIEEFPTAGYINYGNPPAQSQVWTPQNPVA
PQSSTVAPEEPQNVVPETPAGGTEGGAVPPVEEPVPAPAGPVEDIEIAPGIVIPGDLFGN
G

Enzyme Prediction     

No EC number prediction in MGYG000002406_00212.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	80	247	1e-61	0.943502824858757

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	1.54e-168	39	683	30	661	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	6.89e-126	82	629	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	1.79e-94	45	684	29	763	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	1.05e-75	82	247	12	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
TIGR02071	PBP_1b	1.34e-67	44	623	92	679	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BAC19634.1	0.0	1	721	1	732
CBF97213.1	0.0	1	721	1	732
CBF93693.1	0.0	1	721	1	732
ALC07026.1	0.0	6	721	3	721
QDQ19512.1	0.0	1	721	1	720

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5CXW_A	8.91e-118	279	636	2	365	Structureof the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V [Mycobacterium tuberculosis H37Rv]
5CRF_A	9.35e-114	279	636	2	365	Structureof the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis [Mycobacterium tuberculosis H37Rv],5CRF_B Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis [Mycobacterium tuberculosis H37Rv],5CRF_C Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis [Mycobacterium tuberculosis H37Rv],5CRF_D Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis [Mycobacterium tuberculosis H37Rv]
3UDF_A	4.59e-42	63	628	22	717	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
2JE5_A	3.38e-41	48	606	16	618	StructuralAnd Mechanistic Basis Of Penicillin Binding Protein Inhibition By Lactivicins [Streptococcus pneumoniae R6],2JE5_B Structural And Mechanistic Basis Of Penicillin Binding Protein Inhibition By Lactivicins [Streptococcus pneumoniae R6]
5FGZ_A	5.44e-41	73	621	145	688	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
A0R7G2	1.87e-228	20	671	69	721	Penicillin-binding protein 1A OS=Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) OX=246196 GN=ponA1 PE=3 SV=1
P71707	2.52e-210	20	636	131	755	Penicillin-binding protein 1A OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=ponA1 PE=1 SV=3
P70997	6.26e-55	20	630	14	611	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
O87626	4.73e-49	64	672	52	751	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
P38050	9.81e-49	26	628	17	599	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999919	0.000100	0.000000	0.000000	0.000000	0.000001

TMHMM  Annotations     

start	end
26	48