CAZyme Information: MGYG000002619_00072

Basic Information

• Species: Faecalibacterium prausnitzii_J
• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Ruminococcaceae; Faecalibacterium; Faecalibacterium prausnitzii_J
• CAZyme ID: MGYG000002619_00072
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
860	MGYG000002619_1|CGC2	95045.68	4.8882

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002619	2724245	MAG	China	Asia

• Gene Location: Start: 89441; End: 92023 Strand: -

Full Sequence      

MKCQEAIPISNNEMRKIHRGGEEQPARPMGRKVNVSQSRREVRPAAENRTRAPKAPKTPK
PPKEKSKHPMLRFIGRTLATVLCLGIMLGSVVAVGIVFYVVQATANDGDLLDLDNIQLSQ
SSMVVATDPDTGAQVEYATLRSSNSHRVWADLEQIPSNLQYAFICTEDKDFYSEPGVNFK
RTIGAMINEYLLPIYSSKQGASTLEQQLIKNLTDDNSASGIDGALRKVREIYRALCLSRS
YSKETILEAYLNTISFTGTIQGVQTAANEYFNKDVSQLSLWECATIASITKNPTNYNPYT
NPENLINRRNFIMYNMWQQGVISEEDYRNGAAQPLVLAEEDSGKKPSTVTSYFTDALFSE
VVQDIMVKEGISESEAQKLLYTGGFTIEATVNTKLQSQMENLMLNTDDAYFPAGWHEEEV
TSISDDDVQVFNEDGTPKTRTGEDGTVYYYRNVRTQAAMVTLDYDGNVLAIVGGLGEKTK
SLSLNRAYNVERQTGSTIKPIGAYALGIEYGLVNWSTMLNNSPLYQKQDMIIRDEDYCRK
NGLMGLSDKQLRAYPNAWRSWPRNYGGNYGDGSDIPLWNGLARSLNTIAIRVGDLVGASN
IFNFVYNTLQLNTLDPTNDVGLAQMVMGSQTKGVTPMALAAAFQIFYDGEYTTPHLYTRV
LDRDGNIYLENNATSYQALTPDTAYVMNRLLKNVLFSSVGTASGRYPNSNGMEAFGKTGT
ASDEKDLWFVGGTPYYVTAVWWGYDAPYDMTKTLSKQQAKTRTCVTAWKALMEQAQADLP
YKAFPTSAGVVERRYCTQSGLLAGAGCPSTAVGYYRADDLPDTCTYSHAAPQAAVSTENT
DGAVPTQPVVPTDTSALDTE

Enzyme Prediction     

No EC number prediction in MGYG000002619_00072.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	143	316	4.7e-54	0.943502824858757

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	2.23e-129	72	785	9	606	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	4.14e-126	146	775	1	528	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	2.74e-104	70	815	1	758	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	4.72e-64	138	745	137	658	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam00912	Transgly	1.07e-58	146	316	12	176	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AXB28952.1	0.0	14	860	1	847
CBL02306.1	0.0	29	860	1	832
QIA44319.1	0.0	17	860	1	833
ATL89188.1	0.0	33	860	1	816
ATO98888.1	0.0	33	860	1	816

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	4.71e-53	146	815	39	801	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
4OON_A	1.23e-45	155	821	47	768	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3ZG8_B	1.05e-41	237	745	3	433	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3UDF_A	1.54e-41	151	780	43	720	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3DWK_A	2.05e-39	139	744	20	557	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q97GR5	7.84e-81	73	792	28	683	Penicillin-binding protein 1A OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) OX=272562 GN=pbpA PE=3 SV=1
A7GHV1	3.36e-77	143	802	72	670	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
A5I6G4	1.75e-76	143	802	72	670	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
A7FY32	1.75e-76	143	802	72	670	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
Q891X1	1.58e-75	64	826	10	712	Penicillin-binding protein 1A OS=Clostridium tetani (strain Massachusetts / E88) OX=212717 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000072	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
78	100