CAZyme Information: MGYG000003462_00651

Basic Information

• Species: Collinsella sp900767675
• Lineage: Bacteria; Actinobacteriota; Coriobacteriia; Coriobacteriales; Coriobacteriaceae; Collinsella; Collinsella sp900767675
• CAZyme ID: MGYG000003462_00651
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
740		78744.87	4.6151

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003462	2286053	MAG	Fiji	Oceania

• Gene Location: Start: 3692; End: 5914 Strand: +

Full Sequence      

MGPRQRQGRSRSKTHALPMILLSFLGLLLIAGVAFGIGMIGNVNRWLSDLPDYTDANAYL
VSEPTEIVDCNGNKIASFYTQNRKSITKDQVSPYVLQGTVDVEDERFYEHGGIDLWGIAR
AAVATLSGGHEGASTITQQLVRNTILQEEQFDSTIERKVREAYIAIKMEEMYSKDEILMM
YLNTIYYGHGAYGIEAAAETYLSKSAADLTLSEAALLIGLPNSPSQYDPTVNPDLALSRR
NKVLDNMLRLGHITQKEHDAAQAEPITLNVTEISGSGVDVYSQPYFVAYVKQLLEQEFST
DVLFKGGLTVKTTIDPTMQQTAEEAVRAQLDTLSLDGLDMGMVVVDPKTGYIKCMVGGYD
YNADENHVNHATAKRPVGSTFKAFTLATAIQNGMNPNVTLNCNSPLTAKGTTTKVQNYAN
QSYGTITLKQATAYSSNTGYIQVAEAIGNNKIMSLVKKLGIDPSKDNIEDVPVMTLGTGS
ISPLEMAAAYATFANGGYYRQPIAITEIDSRTGSVLYQHTDNPSQVLSTGEAAAVTDVLT
GVMQGSGTGAAGALSVNQPYAGKTGTTDNTTNLWFCGYTPQLACALWTGYSAGEIPIQKY
GMDLLGDSTNLPVFKKFMNTVLAGTGREEFPTGTAPTYKNNNVWKFYGTSSARKSENEEA
EDKGGTTTTTTTTTTTTETTGGDTTGGNGATGGDGTTGGDGTTGGGSGGEGGSPTPTPTP
TPTPTPTPTPTPTPDPSTGQ

Enzyme Prediction     

No EC number prediction in MGYG000003462_00651.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	72	247	5e-66	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	0.0	82	624	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	0.0	30	631	24	606	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	7.24e-157	30	630	13	727	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	2.36e-84	71	248	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
PRK11636	mrcA	3.43e-82	50	631	33	794	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QIA33680.1	0.0	1	689	1	692
AZH69246.1	0.0	1	689	1	692
ATP53936.1	0.0	1	654	1	654
AEB07395.1	1.42e-282	1	652	1	652
QWT17307.1	7.07e-270	1	646	1	646

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	1.58e-63	58	625	14	719	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	3.58e-62	64	622	20	723	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5FGZ_A	1.27e-58	103	601	176	678	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	1.66e-58	103	601	197	699	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
3DWK_A	1.11e-56	64	601	7	564	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P70997	9.14e-86	53	654	43	642	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
P38050	1.14e-80	55	590	39	570	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
O66874	7.51e-79	33	630	13	676	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
O87626	1.56e-70	35	625	19	708	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
A7GHV1	8.68e-70	9	589	5	617	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.963158	0.019093	0.000161	0.000140	0.000068	0.017403

TMHMM  Annotations     

start	end
21	43