CAZyme Information: MGYG000003589_00086

Basic Information

• Species: Dysosmobacter sp900770295
• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Oscillospiraceae; Dysosmobacter; Dysosmobacter sp900770295
• CAZyme ID: MGYG000003589_00086
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A/1B

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
782		85244.11	4.3128

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003589	2941827	MAG	Fiji	Oceania

• Gene Location: Start: 229; End: 2577 Strand: +

Full Sequence      

MENKEHLDTLPVEKKRTWPRRLLLGALVCLAALAAACIAFVGYTVATAPALDTGDVSPDG
YRTTVLDDGGEEMVTLVGEASNRVYVTLDQIPEDLQNAFIAIEDERFWQHPGIDPKGIAR
AAWRNLTSGGLSEGASTITQQLIKNNVFAAGTAERTALDKIQRKIQEQYLALRLERQTSK
EWILENYLNTINLGGGTWGVQTAAMRYFGKEVSELTLSECAVLAGITKSPNYYNPLKNPE
ASRERQELVLAKMLELGMVSREAYDDALADDVYGRLTETSTPGVTTDILSYFEDALVYEV
LDDLVDRLGYTEEDAWRLLYRGGLTIYATQDSELQAICEEEINRDSWYSSDAQASVVVMD
PATGQVKAIVGGRGEKDGSLTFNRAISSVRQPGSVIKIVGEYAAALDTGAITLGTVIDDA
PATYTDGTAIRNASGKFGGMTTIRSGIANSTNVLALKCFQQTGMDTVWSYLQTFGLTHLT
GEDRVEALALGGTHGGVTNLEMTAAYSAIANGGTYTEPTFYTKVLDREGNVLLENTPERH
TAVRSTTAALLTSAMEDVLTSGTGTRAWFSGMDLAGKSGTTTDLRDLWFVGYSPYYACGV
WGGYDDFSAQSSSAYVKNIWKAVMQRAHQGLSRRDFTGTEELTPCTICTKCGALAVEDLC
DSTVQGDMTYREYFVPGTEPTEACTCHVAVEVCQDSGQIAGTYCPESSVERSVYLRSGTA
GTADAEAVVPEGLGEETCQVHQHWWSWLFPEDGQDPQTPEEPTPEERPNGNRPGWGGWFN
WW

Enzyme Prediction     

No EC number prediction in MGYG000003589_00086.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	75	253	5.1e-67	0.9548022598870056

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	0.0	82	630	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	2.72e-178	63	640	56	609	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	2.67e-158	63	689	49	773	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	4.99e-97	79	628	143	683	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11636	mrcA	2.47e-87	68	698	54	845	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AEN95629.1	6.63e-229	45	764	57	848
CBL12211.1	2.22e-224	45	741	57	838
VCV20745.1	2.22e-224	45	741	57	838
CBL09910.1	2.22e-224	45	741	57	838
ACR74490.1	2.25e-220	47	741	59	833

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	1.40e-88	48	714	5	842	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
3ZG8_B	6.21e-69	174	637	3	470	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
4OON_A	4.51e-64	67	605	26	696	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3DWK_A	1.75e-63	59	635	4	592	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
3ZG7_B	1.98e-63	174	637	3	470	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
A7GHV1	2.22e-111	47	716	41	731	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
A5I6G4	2.49e-110	47	716	41	731	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
A7FY32	2.49e-110	47	716	41	731	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A0PZT1	1.55e-107	41	716	46	764	Penicillin-binding protein 1A OS=Clostridium novyi (strain NT) OX=386415 GN=pbpA PE=3 SV=1
Q891X1	5.20e-102	14	690	9	716	Penicillin-binding protein 1A OS=Clostridium tetani (strain Massachusetts / E88) OX=212717 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.968120	0.007278	0.020071	0.000091	0.000048	0.004397

TMHMM  Annotations     

start	end
21	43