CAZyme Information: MGYG000003753_00547

Basic Information

• Species: Criibacterium bergeronii
• Lineage: Bacteria; Firmicutes_A; Clostridia; Peptostreptococcales; Filifactoraceae; Criibacterium; Criibacterium bergeronii
• CAZyme ID: MGYG000003753_00547
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
846		93166.28	4.9494

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003753	1981101	MAG	Canada	North America

• Gene Location: Start: 85691; End: 88231 Strand: -

Full Sequence      

MKGSSIIKSIFKFIFIFILAISIIVVVIVSAIMIAVSKNFPDIDQMKLQSMLQETSYIYD
DAGNISEKVQSGIDRTIVPIEQIPMDLQKAFIAIEDERFYEHGGVDFKRLIGALVHDIKV
GSFEQGGSTINMQLSKNLLTSTEKSALRKVTDIVYAIKLDQKLDKSDIMYAYLNTVFLGS
NVNGVQAAARAYFNKDVGDLSLMECAIIAGITQYPTKYIPYTLSEITPQDDISSLQIKLY
PPSNGNVVPTEVQKQVYDALKNAGKIDYYEDMMLKNGSLVVTKATLNPKSVERGKVVLSK
MRELGIINEEKYQGALNENVIINFPKRNNRDISTYFNDRVKKEAVKILVEQGNTEEQANN
LLKFGGLKIYSTLNTKIQQILEREFANKANFPNSYFDQNGVIQPQAAMVIIDQHTGDVKA
YIGGRGQYGSLIFDRADNPRQPGSAIKPLAVYLLALKDGMTPNTMINDKPREDSTSPTGF
WPKNIHGVYYGNRTMKFLLAVSSNVAAVKTLETLAPTKIAAANRSLDYLTQMGFKHLVRS
SENPAVNDENLSLALGGLTKGVTTLEMTSAYAGIANLGKQNSPVFITKILDSTDKVIYES
KPKVFEMISENKASQMVDMLVGVVKSGSATSAKLSNMPSAGKTGTTSDVKDVYFAGFTPY
YTGSIWIGSDTPRELSYTSEIPTKLWAKVMNKIDSELSLEPKGFNKSDKPYDPSEEEIDS
LDGDTQQTNAVEPTENQQLDGIIFEENQGQQNQDIQTNTVEPNQGQQAPSTNSEQQSNND
NNNTQNAGSKPQQPVQPQPPATEPTPERPKPSAHEDTGQQSAPPVSYENSQPAQDNGGSI
DDSPIF

Enzyme Prediction     

No EC number prediction in MGYG000003753_00547.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	67	223	2.1e-55	0.8757062146892656

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	3.04e-161	74	691	1	526	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.89e-143	55	720	55	623	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	1.79e-116	34	679	28	701	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02073	PBP_1c	4.52e-69	72	668	30	516	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	7.56e-69	72	696	55	564	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
CBH21448.1	3.92e-224	32	698	46	709
AHM56289.1	2.03e-205	30	708	37	712
EFE27596.2	1.53e-188	42	706	24	690
QQT91383.1	1.65e-172	2	704	10	731
QQE47660.1	2.33e-172	2	704	10	731

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	4.82e-102	38	705	3	770	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
3UDF_A	8.01e-61	78	692	40	714	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3ZG8_B	1.56e-54	158	677	2	440	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3DWK_A	8.97e-53	51	695	1	590	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
4OON_A	1.85e-51	52	710	17	727	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q97GR5	1.65e-105	30	711	48	688	Penicillin-binding protein 1A OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) OX=272562 GN=pbpA PE=3 SV=1
A5I6G4	8.25e-97	32	723	34	668	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
A7FY32	8.25e-97	32	723	34	668	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A7GHV1	1.50e-96	32	723	34	668	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
Q8XJ01	2.73e-96	33	697	50	669	Penicillin-binding protein 1A OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.938462	0.003224	0.000251	0.000030	0.000015	0.058038

TMHMM  Annotations     

start	end
13	35