CAZyme Information: MGYG000004259_00117

Basic Information

• Species: Atopobium minutum
• Lineage: Bacteria; Actinobacteriota; Coriobacteriia; Coriobacteriales; Atopobiaceae; Atopobium; Atopobium minutum
• CAZyme ID: MGYG000004259_00117
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
691		75308.76	4.9254

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004259	1625916	MAG	China	Asia

• Gene Location: Start: 130256; End: 132331 Strand: +

Full Sequence      

MGVRTRRAHRHAQTHAFGFGVLGVFGFIGLLGIALMVSLGSLMAFWLTDLPDYKSADAYL
VAEPTTVYDVKGNVIANFYLQNRKSVTMEDVSPYVLKGTVDTEDLRFYKHNGVDPYGIMR
AIFSNASGGSEGASTITQQLVRNTVLSDEQFDKTIKRKVREAYIAVEMEKTYTKDQILMM
YLNTIYYGQGAYGIEAASITYFNKHANELTLAEAATLVGIPNSPTAYDPTVNPNDSKARR
NLVLKRMLKQGDITQEEYDAASQEDIVLNRGQSVTSEKGKYPYFTSYIASLLSEDFDAKT
IYQGGMKVYTTLDPDKQEAAEKAVQAQLDSIGNKELESALVAINNKNGYIDAMVGGRDYD
TNQFNLATQARRQPGSSFKAFTLAAAISQGLNPQTYLNCNSPIQVTPTWRVQNYGNTNYG
TISFARATEISSNTGYVQVAQAIGGSAISSTAKSMGIGVDIPSYASITLGTIGVPPIQMA
EAYSTLANNGIHRNAVAITKIEDRNNNTVYEHKEQSSQAISGEVAYATTQVLQGVVSNGT
ATAVRSYAPHVNQPIAGKTGTTENARDLWFVGYTPQTTVAVWTGFREEKTIYVHGSAGHP
SNTSCPILGRYLEMTLAGAERQEFTSSPAPTYKPASSWPFAKYQKPETLAQTLEDNSQTE
EETDQQDTDDTEPTTSTAPDSNSSDEAAGDE

Enzyme Prediction     

No EC number prediction in MGYG000004259_00117.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	72	247	1.7e-68	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	0.0	17	679	10	660	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	0.0	82	618	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	1.17e-169	28	625	11	728	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
PRK09506	mrcB	6.95e-91	100	613	228	744	bifunctional glycosyl transferase/transpeptidase; Reviewed
PRK11636	mrcA	2.67e-89	30	585	16	743	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BCV18421.1	7.84e-287	1	642	1	643
ADK67697.1	1.16e-284	1	640	1	640
SDR66234.1	3.68e-283	1	659	1	661
BBH49739.1	4.03e-267	1	641	1	642
QUC02420.1	5.32e-267	1	641	1	642

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	1.63e-68	58	618	14	718	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5FGZ_A	5.60e-68	102	612	175	690	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	7.80e-68	102	612	196	711	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
4OON_A	5.44e-66	64	616	20	723	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3FWL_A	1.34e-64	102	612	179	694	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	3.65e-93	28	628	6	680	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P38050	3.33e-88	67	625	51	605	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
P70997	2.12e-86	53	591	43	587	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
O87626	1.42e-84	22	618	16	707	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
O05131	1.99e-82	17	620	14	710	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae OX=485 GN=mrcA PE=1 SV=3

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.998328	0.001561	0.000014	0.000013	0.000006	0.000139

TMHMM  Annotations     

start	end
17	39