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CAZyme Information: MGYG000000001_00777

You are here: Home > Sequence: MGYG000000001_00777

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species GCA-900066495 sp902362365
Lineage Bacteria; Firmicutes_A; Clostridia; Peptostreptococcales; Peptostreptococcaceae; GCA-900066495; GCA-900066495 sp902362365
CAZyme ID MGYG000000001_00777
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
728 MGYG000000001_7|CGC1 83357.29 5.0225
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000001 3219617 Isolate United Kingdom Europe
Gene Location Start: 36471;  End: 38657  Strand: +

Full Sequence      Download help

MGVLFNEKNN  TFCLNTKKTS  YILKVLNSKH  LDHLYWGKKI  RSTNLDYVIR  RRNWGSFLAN60
TDNEENFMLE  MTPQEYPGYG  ATDLRSPAIE  LQFEDGTTAT  DFRYVSHKIY  AGKNKLTGLP120
STYVEDEKEA  TTLEIVLKDT  LKSVEIILTY  TVFEEFDVIT  RNAKVINTGN  EDIKILRALS180
ASVDFNDDDF  DMIQLSGAWA  RERDFIRQPL  RSGSQSIESR  RGSSSHAQNP  FIALARKNTT240
ETNGDIYGFS  FVYSGNFLAN  VEVDMYKNAR  AQIGINPFDF  TWLLNSGESF  QTPEAVLVYS300
GEGMTGMSHI  YHNIYGKRLA  RGEHRDKIRP  ILINNWEATY  FDFNENSIKS  IAKEASNLGM360
ELFVLDDGWF  GKRNNDDCSL  GDWIVNEEKI  KGGLEKLAKE  VNEMGLQFGL  WFEPEMVCPV420
SDLYEAHPDW  CIHIPGRTRS  EARMQLILDL  SRDDVCDYII  KAVSDVLSSA  PISYVKWDMN480
RNMTEIGSAK  LTPERQRELT  HRYMLGLYRI  LEELITKFPH  ILFESCSGGG  GRFDPGMLHY540
MPQTWTSDNT  DSMERLKIQY  GTSLVYPNVS  MGCHVSAIPN  HQVHRMTPLN  TRGVVAMSGN600
FGYELDITKL  SNEEKSMIKE  QVAVYKEIRE  TIQFGDYYRL  SNPFENNDVA  WMFISKDSNE660
VVVSYVRQRA  VPNPRFESLK  LVGLEEDATY  EIVGEDKVFF  GDELMYVGLN  VEELTGDYAA720
KMWVLRKV728

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap367210914518221825429132736440043647350954658261865569112710GH36
Family Start End Evalue family coverage
GH36 12 710 2e-286 0.9956395348837209

CDD Domains      download full data without filtering help

Created with Snap36721091451822182542913273644004364735095465826186556919728GalA289635Melibiase329627GH3630285Glyco_hydro_36N649725Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 0.0 9 728 1 687
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 0.0 289 635 1 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 3.30e-143 329 627 2 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 7.21e-128 30 285 2 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 4.77e-28 649 725 2 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap36721091451822182542913273644004364735095465826186556911728CED94005.1|GH361728AQS08778.1|GH361728AQR99055.1|GH361728AQR89154.1|GH361728AQS13043.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
CED94005.1 0.0 1 728 1 728
AQS08778.1 0.0 1 728 1 728
AQR99055.1 0.0 1 728 1 728
AQR89154.1 0.0 1 728 1 728
AQS13043.1 0.0 1 728 1 728

PDB Hits      download full data without filtering help

Created with Snap367210914518221825429132736440043647350954658261865569117284FNT_A17284FNR_A17284FNQ_A17284FNP_A17284FNU_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNT_A 0.0 1 728 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]
4FNR_A 0.0 1 728 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNQ_A 0.0 1 728 1 727
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNP_A 0.0 1 728 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]
4FNU_A 0.0 1 728 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap36721091451822182542913273644004364735095465826186556911728sp|Q9ALJ4|AGAA_GEOSE3728sp|G1UB44|MELA_LACAC3728sp|P43467|AGAL1_PEDPE1720sp|G4T4R7|AGASK_RUMGN1727sp|P27756|AGAL_STRMU
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 0.0 1 728 1 727
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 2.56e-222 3 728 6 731
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 1.06e-221 3 728 4 730
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G4T4R7 1.98e-212 1 720 1 712
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
P27756 8.53e-193 1 727 1 719
Alpha-galactosidase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=aga PE=3 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000071 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000001_00777.