CAZyme Information: MGYG000000002_03690

Basic Information

• Species: Blautia_A faecis
• Lineage: Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Blautia_A; Blautia_A faecis
• CAZyme ID: MGYG000000002_03690
• CAZy Family: GT2
• CAZyme Description: Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1034		118480.17	5.4504

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000002	4433109	Isolate	United Kingdom	Europe

• Gene Location: Start: 2837; End: 5941 Strand: -

Full Sequence      

MKSFKVSIILPVYNVEKYLSACLDSLLAQTLEEIEIVAVNDGSTDGSLQILQAYQSLNPE
KLFIFSTENHGVSRARNYGFAHSHGEYVWFVDSDDFVEPDACRLLYEKATADGNDLVLFR
YYNVDSETGVRKEYIASCHNQNFRVADKPYELPAISPYPWIKFIHRDLFNGLCFPEGIRF
EDLPVAYLLAVKARSIGYVDQCFYNYRKNVGFLSRLTPSTLHIRNAIIFMKEEMEKLGLF
EQYQTELDFIAVRHFFYRFWKLLTNYETDQKELKLQLINELFDYMESNIPDWENNHYVRY
SLPPHIGRLLCLYGSRQEMISFVEACNGMTVQQQKAWIKDYKLSHKTSPSYQPAEMIHRE
KTSSQFYGFAYTGSLAPDPEQILLEASRGKEIPTWILKLLVHLLRNFGEHQIIVSLTQEK
HALFQALLNRYLSDSTALSENITLVCPDSEEYGKALALSGYVITDGPLPYYFRKEEGQFV
LLYCGHNLYPETVLNTPDSTADTGLWQHTMFMADCLYFNNVQNRDIYLQECMTANICKTP
YIIGSSTHIPVIPNESHREKLRRSLQMDSMQTILYAPLLPGSYIADTEQAFRNFMAALYI
FDCELSDHQVLYLHLDHEREIDFSEFRHIKEMPKDFDVPDFAAACDIFISDYHNALSARF
TTGTQILRFLCGTFLRHENATSDHQTVPAAPVLQETTSCLPESSGACLKNHSCNLHSTLC
DVFHPEYPAFDNVPELVRYIRQLELISEKMPANEALHFEPVDQFTSNTGHGFDSQEYDWN
SSKKSSLQMENNHDLQTTKNSSGEATTFEESPQYLLTDIADSLLNGRPLPYYAPASSDDV
PAPRTRVLFFTGRKLSQNLVRDFNALAAQAPEKEFWLAYNDFRNTDSAKYLAQLSPDCSS
LPLKPDPEKGNRWKLASVLTSRMGLFSFYPLSHILDLGKEEYKKCMGETRFDEVVITSTD
SIKTVATLLAAAPKASYTFDTFNPERYSTSRPYRHQIAFLCRMLKDTGSLELPAELTGLK
LTQSSGKNKDKGML

Enzyme Prediction     

No EC number prediction in MGYG000000002_03690.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT2	7	134	2.7e-36	0.7529411764705882

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam00535	Glycos_transf_2	4.42e-39	7	183	1	164	Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
cd00761	Glyco_tranf_GTA_type	3.42e-34	8	114	1	107	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.
PRK10073	PRK10073	8.55e-34	5	237	7	249	putative glycosyl transferase; Provisional
COG0463	WcaA	1.98e-31	5	301	4	290	Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis].
cd06423	CESA_like	1.84e-22	8	114	1	108	CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QHQ61047.1	4.79e-117	1	1019	1	950
BCJ93365.1	3.31e-107	1	1019	1	950
BCK00831.1	3.77e-100	1	1020	1	951
ABX40684.1	7.61e-98	10	656	1	667
BBK23790.1	7.65e-59	6	667	6	655

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5HEA_A	2.63e-30	6	215	7	224	CgTstructure in hexamer [Streptococcus parasanguinis FW213],5HEA_B CgT structure in hexamer [Streptococcus parasanguinis FW213],5HEA_C CgT structure in hexamer [Streptococcus parasanguinis FW213],5HEC_A CgT structure in dimer [Streptococcus parasanguinis FW213],5HEC_B CgT structure in dimer [Streptococcus parasanguinis FW213]
3BCV_A	7.19e-20	5	209	6	227	Crystalstructure of a putative glycosyltransferase from Bacteroides fragilis [Bacteroides fragilis NCTC 9343],3BCV_B Crystal structure of a putative glycosyltransferase from Bacteroides fragilis [Bacteroides fragilis NCTC 9343]
2Z87_A	7.63e-16	6	112	376	481	Crystalstructure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GalNAc and UDP [Escherichia coli],2Z87_B Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GalNAc and UDP [Escherichia coli]
2Z86_A	7.65e-16	6	112	377	482	Crystalstructure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP [Escherichia coli],2Z86_B Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP [Escherichia coli],2Z86_C Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP [Escherichia coli],2Z86_D Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP [Escherichia coli]
5TZE_C	3.90e-13	5	211	2	208	Crystalstructure of S. aureus TarS in complex with UDP-GlcNAc [Staphylococcus aureus],5TZE_E Crystal structure of S. aureus TarS in complex with UDP-GlcNAc [Staphylococcus aureus],5TZI_C Crystal structure of S. aureus TarS 1-349 [Staphylococcus aureus],5TZJ_A Crystal structure of S. aureus TarS 1-349 in complex with UDP-GlcNAc [Staphylococcus aureus],5TZJ_C Crystal structure of S. aureus TarS 1-349 in complex with UDP-GlcNAc [Staphylococcus aureus],5TZK_C Crystal structure of S. aureus TarS 1-349 in complex with UDP [Staphylococcus aureus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
A0A0H2URH7	4.53e-28	5	222	6	232	Glycosyltransferase GlyA OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=glyA PE=3 SV=1
A0A0H2UR96	4.57e-28	6	274	5	282	Glycosyltransferase GlyG OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=glyG PE=1 SV=1
P71057	8.14e-28	1	254	1	261	Putative glycosyltransferase EpsH OS=Bacillus subtilis (strain 168) OX=224308 GN=epsH PE=2 SV=1
P71059	7.42e-26	6	249	5	241	Uncharacterized glycosyltransferase EpsJ OS=Bacillus subtilis (strain 168) OX=224308 GN=epsJ PE=2 SV=1
P46918	2.93e-21	3	289	7	303	Minor teichoic acid biosynthesis protein GgaB OS=Bacillus subtilis (strain 168) OX=224308 GN=ggaB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000054	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000002_03690.