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CAZyme Information: MGYG000000012_03321
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Bacillus subtilis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus; Bacillus subtilis | |||||||||||
| CAZyme ID | MGYG000000012_03321 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Tyrocidine synthase 2 | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 80442; End: 84938 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK05691 | PRK05691 | 0.0 | 10 | 1496 | 1730 | 3247 | peptide synthase; Validated |
| PRK12316 | PRK12316 | 0.0 | 10 | 1496 | 2604 | 4092 | peptide synthase; Provisional |
| PRK12316 | PRK12316 | 0.0 | 10 | 1496 | 51 | 1546 | peptide synthase; Provisional |
| cd17655 | A_NRPS_Bac | 0.0 | 461 | 949 | 1 | 489 | bacitracin synthetase and related proteins. This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. |
| PRK12316 | PRK12316 | 0.0 | 7 | 1357 | 1555 | 2912 | peptide synthase; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QND46664.1 | 2.35e-138 | 8 | 1037 | 1614 | 2666 |
| AFZ04852.1 | 5.25e-120 | 191 | 1043 | 317 | 1178 |
| BAZ00088.1 | 5.63e-113 | 192 | 1036 | 313 | 1181 |
| BAZ75991.1 | 5.63e-113 | 192 | 1036 | 313 | 1181 |
| BAY30132.1 | 2.39e-112 | 192 | 1036 | 313 | 1183 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6P1J_A | 2.97e-125 | 4 | 946 | 1 | 964 | Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae],6P1J_B The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae] |
| 6MFZ_A | 3.77e-118 | 15 | 1037 | 792 | 1801 | Crystalstructure of dimodular LgrA in a condensation state [Brevibacillus parabrevis],6MFZ_B Crystal structure of dimodular LgrA in a condensation state [Brevibacillus parabrevis] |
| 1AMU_A | 4.47e-113 | 438 | 981 | 20 | 556 | PhenylalanineActivating Domain Of Gramicidin Synthetase 1 In A Complex With Amp And Phenylalanine [Brevibacillus brevis],1AMU_B Phenylalanine Activating Domain Of Gramicidin Synthetase 1 In A Complex With Amp And Phenylalanine [Brevibacillus brevis] |
| 6MFW_A | 4.88e-109 | 456 | 1238 | 204 | 964 | Crystalstructure of a 4-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis] |
| 6MFX_A | 1.23e-108 | 456 | 1238 | 204 | 964 | Crystalstructure of a 4-domain construct of a mutant of LgrA in the substrate donation state [Brevibacillus parabrevis] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q9R9J0 | 7.39e-252 | 7 | 1496 | 1317 | 2816 | Mycosubtilin synthase subunit B OS=Bacillus subtilis OX=1423 GN=mycB PE=3 SV=1 |
| O30408 | 2.60e-231 | 9 | 1498 | 2098 | 3585 | Tyrocidine synthase 2 OS=Brevibacillus parabrevis OX=54914 GN=tycB PE=1 SV=1 |
| P27206 | 4.96e-229 | 9 | 1498 | 2101 | 3585 | Surfactin synthase subunit 1 OS=Bacillus subtilis (strain 168) OX=224308 GN=srfAA PE=1 SV=4 |
| O68007 | 1.84e-224 | 9 | 1496 | 1107 | 2598 | Bacitracin synthase 2 OS=Bacillus licheniformis OX=1402 GN=bacB PE=3 SV=1 |
| P39847 | 6.41e-223 | 9 | 1496 | 1058 | 2548 | Plipastatin synthase subunit C OS=Bacillus subtilis (strain 168) OX=224308 GN=ppsC PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000078 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |