dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000000013_03164

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Basic Information help

Species

Bacteroides sp902362375

Lineage

Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides sp902362375

CAZyme ID

MGYG000000013_03164

CAZy Family

GH33

CAZyme Description

Arylsulfatase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
466	MGYG000000013_7\|CGC8	51350	5.3095

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000013	6368149	Isolate	United Kingdom	Europe

Gene Location

Start: 385460; End: 386860 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000000013_03164.

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd16026	GALNS_like	0.0	39	439	1	398	galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS). Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
cd16144	ARS_like	1.36e-122	40	457	1	421	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16143	ARS_like	1.23e-118	40	440	1	395	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16146	ARS_like	3.16e-118	40	450	1	397	uncharacterized arylsulfatase. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16145	ARS_like	1.73e-116	40	444	1	415	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
VTR91273.1	6.35e-130	36	450	20	442
VTS00049.1	2.53e-124	36	465	20	461
AWM40795.1	2.53e-124	36	465	20	461
QEG25923.1	2.53e-124	36	465	20	461
QDT08292.1	5.69e-107	39	462	735	1155

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1E33_P	1.40e-76	40	450	3	438	Crystalstructure of an Arylsulfatase A mutant P426L [Homo sapiens]
1E1Z_P	2.77e-76	40	450	3	438	Crystalstructure of an Arylsulfatase A mutant C69S [Homo sapiens]
1E3C_P	2.77e-76	40	450	3	438	Crystalstructure of an Arylsulfatase A mutant C69S soaked in synthetic substrate [Homo sapiens]
1E2S_P	7.69e-76	40	450	3	438	Crystalstructure of an Arylsulfatase A mutant C69A [Homo sapiens]
1AUK_A	1.52e-75	40	450	3	438	HumanArylsulfatase A [Homo sapiens],1N2K_A Crystal structure of a covalent intermediate of endogenous human arylsulfatase A [Homo sapiens],1N2L_A Crystal structure of a covalent intermediate of endogenous human arylsulfatase A [Homo sapiens]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q08DD1	7.47e-82	36	463	17	465	Arylsulfatase A OS=Bos taurus OX=9913 GN=ARSA PE=2 SV=1
P15289	4.73e-75	37	450	18	456	Arylsulfatase A OS=Homo sapiens OX=9606 GN=ARSA PE=1 SV=3
P50428	1.79e-74	37	463	17	464	Arylsulfatase A OS=Mus musculus OX=10090 GN=Arsa PE=1 SV=2
Q96EG1	4.31e-73	38	456	34	492	Arylsulfatase G OS=Homo sapiens OX=9606 GN=ARSG PE=1 SV=1
Q3TYD4	1.27e-71	37	456	33	488	Arylsulfatase G OS=Mus musculus OX=10090 GN=Arsg PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000002	0.001173	0.998863	0.000000	0.000001	0.000000

TMHMM Annotations help

There is no transmembrane helices in MGYG000000013_03164.