dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000000019_00849

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Basic Information help

Species

Enterobacter cloacae_O

Lineage

Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Enterobacter; Enterobacter cloacae_O

CAZyme ID

MGYG000000019_00849

CAZy Family

GH18

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
900	MGYG000000019_3\|CGC2	96457.88	4.6725

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000019	4947669	Isolate	United Kingdom	Europe

Gene Location

Start: 82774; End: 85476 Strand: +

Full Sequence Download help

Enzyme Prediction help

EC	3.2.1.14

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH18	156	550	4.8e-76	0.9493243243243243

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd06548	GH18_chitinase	3.41e-129	159	547	1	322	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
smart00636	Glyco_18	9.14e-128	158	547	1	334	Glyco_18 domain.
COG3325	ChiA	7.70e-125	120	564	1	441	Chitinase, GH18 family [Carbohydrate transport and metabolism].
pfam00704	Glyco_hydro_18	6.01e-90	158	547	1	307	Glycosyl hydrolases family 18.
cd02872	GH18_chitolectin_chitotriosidase	7.38e-71	162	559	4	362	This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits help

Hit ID	Query Start	Query End	Hit Start	Hit End
QLA67096.1	1	900	1	900
QCZ37937.1	1	900	1	900
QCC97989.1	1	900	1	900
QCD10082.1	1	900	1	900
QCC92988.1	1	900	1	900

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2WK2_A	3.11e-269	23	562	1	536	ChitinaseA from Serratia marcescens ATCC990 in complex with Chitotrio-thiazoline dithioamide. [Serratia marcescens]
2WLY_A	4.17e-269	23	562	1	536	ChitinaseA from Serratia marcescens ATCC990 in complex with Chitotrio-thiazoline. [Serratia marcescens],2WLZ_A Chitinase A from Serratia marcescens ATCC990 in complex with Chitobio- thiazoline. [Serratia marcescens],2WM0_A Chitinase A from Serratia marcescens ATCC990 in complex with Chitobio- thiazoline thioamide. [Serratia marcescens]
1RD6_A	1.02e-268	2	562	3	559	ChainA, Chitinase A [Serratia marcescens],1X6L_A Chain A, Chitinase A [Serratia marcescens],1X6N_A Chain A, Chitinase A [Serratia marcescens]
1EDQ_A	1.26e-268	23	562	1	536	CrystalStructure Of Chitinase A From S. Marcescens At 1.55 Angstroms [Serratia marcescens],1FFQ_A Crystal Structure Of Chitinase A Complexed With Allosamidin [Serratia marcescens]
1CTN_A	2.52e-268	23	562	1	536	CRYSTALSTRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION [Serratia marcescens]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P07254	4.26e-270	2	562	3	559	Chitinase A OS=Serratia marcescens OX=615 GN=chiA PE=1 SV=3
P32823	5.20e-219	14	848	13	819	Chitinase A OS=Pseudoalteromonas piscicida OX=43662 GN=chiA PE=1 SV=1
P41684	4.34e-217	11	556	9	542	Chitinase OS=Autographa californica nuclear polyhedrosis virus OX=46015 GN=CHIA PE=1 SV=1
O10363	7.91e-212	23	557	16	542	Probable endochitinase OS=Orgyia pseudotsugata multicapsid polyhedrosis virus OX=262177 GN=ORF124 PE=3 SV=1
P20533	1.13e-67	159	749	46	638	Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000264	0.998976	0.000178	0.000205	0.000189	0.000173

TMHMM Annotations download full data without filtering help

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