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CAZyme Information: MGYG000000025_02647
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Staphylococcus nepalensis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; Staphylococcales; Staphylococcaceae; Staphylococcus; Staphylococcus nepalensis | |||||||||||
| CAZyme ID | MGYG000000025_02647 | |||||||||||
| CAZy Family | GH19 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 4598; End: 6622 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH19 | 385 | 500 | 4.9e-19 | 0.4935064935064935 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK06347 | PRK06347 | 4.29e-28 | 95 | 318 | 316 | 591 | 1,4-beta-N-acetylmuramoylhydrolase. |
| cd12797 | M23_peptidase | 3.56e-27 | 562 | 648 | 1 | 84 | M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins. This model describes the metallopeptidase M23 family, which includes beta-lytic metallopeptidase and lysostaphin. Members of this family are zinc endopeptidases that lyse bacterial cell wall peptidoglycans; they cleave either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptide (e.g. beta-lytic endopeptidase) or a bond within the cross-linking peptide (e.g. stapholysin, and lysostaphin). Beta-lytic metallopeptidase, formerly known as beta-lytic protease, has a preference for cleavage of Gly-X bonds and favors hydrophobic or apolar residues on either side. It inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent. Lysostaphin, produced by Staphylococcus genus, cleaves pentaglycine cross-bridges of cell wall peptidoglycan, acting as autolysins to maintain cell wall metabolism or as toxins and weapons against competing strains. Staphylolysin (also known as LasA) is implicated in a range of processes related to Pseudomonas virulence, including stimulating shedding of the ectodomain of cell surface heparan sulphate proteoglycan syndecan-1, and elastin degradation in connective tissue. Its active site is less constricted and contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two metal-bound water molecules, possibly contributing to its activity against a wider range of substrates than those used by related lytic enzymes, consistent with its multiple roles in Pseudomonas virulence. The family includes members that do not appear to have the conserved zinc-binding site and might be lipoproteins lacking proteolytic activity. |
| pfam01551 | Peptidase_M23 | 5.89e-27 | 561 | 655 | 2 | 93 | Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown. |
| PRK06347 | PRK06347 | 3.18e-24 | 12 | 262 | 291 | 591 | 1,4-beta-N-acetylmuramoylhydrolase. |
| COG3179 | COG3179 | 4.20e-24 | 351 | 518 | 3 | 199 | Predicted chitinase [General function prediction only]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| ASB55626.1 | 1.27e-172 | 5 | 523 | 9 | 556 |
| BAI83666.2 | 1.27e-172 | 5 | 523 | 9 | 556 |
| QAW02787.1 | 1.27e-172 | 5 | 523 | 9 | 556 |
| AYK78650.1 | 1.27e-172 | 5 | 523 | 9 | 556 |
| ARI86935.1 | 1.27e-172 | 5 | 523 | 9 | 556 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4QP5_A | 3.38e-41 | 531 | 670 | 2 | 140 | Catalyticdomain of the antimicrobial peptidase lysostaphin from Staphylococcus simulans crystallized in the presence of phosphate [Staphylococcus simulans bv. staphylolyticus],4QP5_B Catalytic domain of the antimicrobial peptidase lysostaphin from Staphylococcus simulans crystallized in the presence of phosphate [Staphylococcus simulans bv. staphylolyticus],4QPB_A Catalytic domain of the antimicrobial peptidase lysostaphin from Staphylococcus simulans crystallized in the absence of phosphate [Staphylococcus simulans],4QPB_B Catalytic domain of the antimicrobial peptidase lysostaphin from Staphylococcus simulans crystallized in the absence of phosphate [Staphylococcus simulans] |
| 5NMY_A | 5.39e-40 | 533 | 670 | 2 | 138 | NMRsolution structure of lysostaphin [Staphylococcus simulans] |
| 4LXC_A | 9.73e-40 | 531 | 670 | 2 | 140 | Theantimicrobial peptidase lysostaphin from Staphylococcus simulans [Staphylococcus simulans],4LXC_B The antimicrobial peptidase lysostaphin from Staphylococcus simulans [Staphylococcus simulans],4LXC_C The antimicrobial peptidase lysostaphin from Staphylococcus simulans [Staphylococcus simulans],4LXC_D The antimicrobial peptidase lysostaphin from Staphylococcus simulans [Staphylococcus simulans] |
| 6RK4_A | 1.40e-37 | 531 | 670 | 248 | 386 | LysostaphinSH3b P4-G5 complex, synchrotron dataset [Staphylococcus simulans] |
| 5KQB_A | 1.39e-32 | 545 | 669 | 12 | 135 | Identificationand structural characterization of LytU [Staphylococcus aureus],5KQC_A Identification and structural characterization of LytU [Staphylococcus aureus] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P10547 | 7.65e-37 | 531 | 670 | 248 | 386 | Lysostaphin OS=Staphylococcus simulans OX=1286 GN=lss PE=1 SV=2 |
| P10548 | 2.14e-36 | 531 | 670 | 235 | 373 | Lysostaphin OS=Staphylococcus staphylolyticus OX=1287 GN=lss PE=3 SV=1 |
| O05156 | 1.97e-35 | 537 | 673 | 125 | 260 | Glycyl-glycine endopeptidase ALE-1 OS=Staphylococcus capitis OX=29388 PE=1 SV=1 |
| Q6GK35 | 1.12e-29 | 447 | 667 | 95 | 314 | Glycyl-glycine endopeptidase LytM OS=Staphylococcus aureus (strain MRSA252) OX=282458 GN=lytM PE=3 SV=1 |
| A0A0H3K6J4 | 1.30e-28 | 528 | 667 | 179 | 314 | Glycyl-glycine endopeptidase LytM OS=Staphylococcus aureus (strain Newman) OX=426430 GN=lytM PE=3 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.999463 | 0.000553 | 0.000004 | 0.000001 | 0.000000 | 0.000001 |