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CAZyme Information: MGYG000000031_02081

You are here: Home > Sequence: MGYG000000031_02081

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Blautia_A sp900066205
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Blautia_A; Blautia_A sp900066205
CAZyme ID MGYG000000031_02081
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
728 MGYG000000031_6|CGC2 83844.79 5.2478
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000031 3671868 Isolate United Kingdom Europe
Gene Location Start: 40911;  End: 43097  Strand: -

Full Sequence      Download help

MSVTFNEEKK  IFRLDTEKST  YVMGLSPEGF  LGHIYYGDRL  FMEADNYLLR  MEEPPYTPSV60
NKREKSAFLD  FFPMEYPTGG  IGDYRESCLN  IRNAAGNMGC  ELHYAGHEIY  KGKRGLKGLP120
ASFSTEDEAE  TLEITLKDAD  LDLEVVLFYT  AFEKENAITR  SVRVQNQGKE  DLRIEKILSA180
CLDMDNENFS  MLSLHGTWAR  ERHIQTGELH  YGKQVISSAR  GESSHQEHPF  IALVTNGTEQ240
ENGKVYAMHF  VYSGNFMAET  ELCQFDNLRM  TMGINPEEFS  WLLTPGEEFQ  APEVVMVYSG300
NGLGAMTRSY  HDFYRNHLIR  SKFKYEKRPI  LINNWEATYF  DFNTDKLLAI  ARQAKECGIE360
MLVMDDGWFG  KRNFDNCSLG  DWKVNEKKIT  GGLKHLVDEV  NKIGLQFGIW  FEPEMISPDS420
DLYRAHPDWA  IQIAGREATQ  SRNQYVLDLS  RPEVRDYAYE  CVASILRSAN  IAYVKWDMNR480
QLSDLGSSYL  PKERQQELFH  RYVLGVYELQ  ERLVTEFPDL  LLENCSGGGA  RFDPGMLYYS540
PQIWCSDNTD  AVERLMIQEG  SALIYPLSVI  GAHVSDCPNH  SVGRVTPFET  RGHVALAGTF600
GYELDITKIP  EEDRVLIPEQ  TVTYNKYRHL  IQQGEYYRIA  SYRENHKYDC  WALSSQDKKE660
VLVTYVQVLG  VPNSHSRKVF  LRGFDPKTTY  RLEGTEETYT  GEMLMKGGFL  MKDFWGDFKS720
RLYHFIAK728

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap367210914518221825429132736440043647350954658261865569111709GH36
Family Start End Evalue family coverage
GH36 11 709 2e-273 0.9956395348837209

CDD Domains      download full data without filtering help

Created with Snap367210914518221825429132736440043647350954658261865569112725GalA289634Melibiase327626GH3629283Glyco_hydro_36N648725Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 0.0 12 725 4 684
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 0.0 289 634 2 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 6.61e-139 327 626 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 1.79e-118 29 283 1 255
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 8.59e-27 648 725 1 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap36721091451822182542913273644004364735095465826186556911728CBL22952.1|GH361726ASU28442.1|GH361726QQQ93196.1|GH361726ANU75639.1|GH361726QJU14265.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
CBL22952.1 0.0 1 728 1 728
ASU28442.1 0.0 1 726 1 726
QQQ93196.1 0.0 1 726 1 726
ANU75639.1 0.0 1 726 1 726
QJU14265.1 0.0 1 726 1 726

PDB Hits      download full data without filtering help

Created with Snap367210914518221825429132736440043647350954658261865569117274FNQ_A17274FNR_A17274FNU_A17274FNT_A17274FNP_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNQ_A 3.73e-250 1 727 1 726
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 5.61e-247 1 727 1 726
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNU_A 5.19e-245 1 727 1 726
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNT_A 7.36e-245 1 727 1 726
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]
4FNP_A 1.04e-244 1 727 1 726
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap36721091451822182542913273644004364735095465826186556911727sp|Q9ALJ4|AGAA_GEOSE1725sp|G4T4R7|AGASK_RUMGN3727sp|G1UB44|MELA_LACAC3727sp|P43467|AGAL1_PEDPE75722sp|Q0CEF5|AGALG_ASPTN
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 3.07e-246 1 727 1 726
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G4T4R7 2.34e-225 1 725 1 717
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
G1UB44 1.89e-219 3 727 6 730
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 1.93e-211 3 727 4 729
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
Q0CEF5 4.28e-171 75 722 72 719
Probable alpha-galactosidase G OS=Aspergillus terreus (strain NIH 2624 / FGSC A1156) OX=341663 GN=aglG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000057 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000031_02081.