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CAZyme Information: MGYG000000034_00603

You are here: Home > Sequence: MGYG000000034_00603

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Massilimaliae timonensis
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Ruminococcaceae; Massilimaliae; Massilimaliae timonensis
CAZyme ID MGYG000000034_00603
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
377 MGYG000000034_1|CGC5 41356.9 8.3326
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000034 2753532 Isolate United Kingdom Europe
Gene Location Start: 612102;  End: 613235  Strand: -

Full Sequence      Download help

MRVLLAGGGT  AGHINPAIAI  AQYIRSQDPA  SEILFAGTPN  GMEAQLVTQA  GFDFAPVQVS60
GFRRKMSAKN  ILFNLKTVYH  VITADFVAKR  IIKDFRPDIV  IGTGGYVSGP  VVLAGAKMGI120
KTMIHEQNAF  PGVTNKLLAK  KVDVVLLAVE  EARQHFDPSA  RCEVVGNPIR  ESVIFKTKEE180
ARRDLGMDNK  VCILSFGGSL  GAKVINRAAA  DLIEWNYQKN  KINHIHGYGR  LGVEHFPQML240
EERGIDLSAL  QAEKADPNID  VREYINNMAT  CLAAADLVIC  RSGAITLSEL  QATGKASILV300
PSPYVAENHQ  FHNAMVLVNH  GAAMLIEEKD  YKKEEFLRMV  ESVYQDREKL  AQLGKNASKL360
AILDSTERIY  RLICGLI377

Enzyme Prediction      help

No EC number prediction in MGYG000000034_00603.

CAZyme Signature Domains help

Created with Snap1837567594113131150169188207226245263282301320339358193362GT28
Family Start End Evalue family coverage
GT28 193 362 1.3e-45 0.9681528662420382

CDD Domains      download full data without filtering help

Created with Snap18375675941131311501691882072262452632823013203393581377murG2372GT28_MurG1373MurG1373murG3146Glyco_transf_28
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 4.62e-139 1 377 2 355
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 1.20e-130 2 372 1 350
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 3.43e-105 1 373 1 351
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 1.39e-101 1 373 1 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam03033 Glyco_transf_28 3.12e-40 3 146 1 138
Glycosyltransferase family 28 N-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.

CAZyme Hits      help

Created with Snap18375675941131311501691882072262452632823013203393581373BCI60898.1|GT281373QAT50143.1|GT281373QEY33586.1|GT281377QCT06982.1|GT281373ANU55131.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
BCI60898.1 6.70e-143 1 373 1 367
QAT50143.1 1.31e-140 1 373 1 366
QEY33586.1 3.87e-139 1 373 1 366
QCT06982.1 2.39e-137 1 377 1 370
ANU55131.1 5.51e-137 1 373 1 366

PDB Hits      download full data without filtering help

Created with Snap183756759411313115016918820722624526328230132033935823691F0K_A23693S2U_A23737D1I_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
1F0K_A 9.63e-52 2 369 8 346
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
3S2U_A 5.71e-50 2 369 4 347
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
7D1I_A 6.79e-47 2 373 11 362
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18375675941131311501691882072262452632823013203393581373sp|A3DE27|MURG_ACET21373sp|B0K8K7|MURG_THEP31373sp|B0K3H0|MURG_THEPX1373sp|B8I6H3|MURG_RUMCH1360sp|A4J2B1|MURG_DESRM
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A3DE27 1.05e-100 1 373 1 359
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=murG PE=3 SV=1
B0K8K7 2.46e-92 1 373 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=murG PE=3 SV=1
B0K3H0 2.46e-92 1 373 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter sp. (strain X514) OX=399726 GN=murG PE=3 SV=1
B8I6H3 6.30e-90 1 373 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) OX=394503 GN=murG PE=3 SV=1
A4J2B1 1.82e-88 1 360 1 351
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Desulfotomaculum reducens (strain MI-1) OX=349161 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000081 0.000003 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000034_00603.