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CAZyme Information: MGYG000000054_01529

You are here: Home > Sequence: MGYG000000054_01529

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Bacteroides acidifaciens
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides acidifaciens
CAZyme ID MGYG000000054_01529
CAZy Family GH20
CAZyme Description Beta-hexosaminidase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
543 MGYG000000054_14|CGC1 61770.64 5.0363
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000054 5213730 Isolate United Kingdom Europe
Gene Location Start: 3070;  End: 4701  Strand: -

Full Sequence      Download help

MKKLIAISVI  SVVIAACDTS  ERVEADYRNV  IPLPHEIVMV  DGNSFVVEKD  TRILYPEDNV60
LLERNAQFLA  GYIEETTGRR  LKVESGQGGN  DENVIMLGLD  ASIDNPEGYE  LTVSPDRVTI120
KGQAANGVFY  GLQTLRKSVP  AIAYGLDIIL  PAAVIKDAPR  FAYRGMMLDV  GRHFFSVDFV180
KRYIDLLAMH  NMNYFHWHLT  EDQGWRIEIK  KYPRLTEIGS  IRKETGIGAS  RTEFDGKPYG240
GFYTQDEIRE  IVKYAQERYV  TVIPEIDLPG  HMLAALAAYP  ELGCTGGPYE  VACHWGVFPD300
VLCLGNEKTY  EFLEGVLAEV  IELFPSKYIH  IGGDEAPRTR  WEMCPKCQGL  AKKEGLKTDR360
EHSTEDRLQS  YCMKRIERYL  NEKGRQIIGW  DEILDGDVAP  NATVMSWRGI  RGGIKAAKLK420
HDVIMTPNDY  MYFDYYQSDD  KTQEPLAMGS  GVTVEKVYGF  EPVAAELENE  EKKHILGVQA480
NVWTEYIATP  EHVEYMMVPR  IAALAEVQWM  MPEEKDYQEF  LKRLNSLVGF  YKRESVNYAK540
HVF543

Enzyme Prediction      help

EC 3.2.1.52 3.2.1.-

CAZyme Signature Domains help

Created with Snap275481108135162190217244271298325352380407434461488515155509GH20
Family Start End Evalue family coverage
GH20 155 509 1.6e-128 0.9703264094955489

CDD Domains      download full data without filtering help

Created with Snap275481108135162190217244271298325352380407434461488515161524GH20_chitobiase-like161509Glyco_hydro_20107538Chb161524GH20_SpHex_like161524GH20_chitobiase-like_1
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06563 GH20_chitobiase-like 0.0 161 524 1 357
The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.
pfam00728 Glyco_hydro_20 9.94e-180 161 509 1 343
Glycosyl hydrolase family 20, catalytic domain. This domain has a TIM barrel fold.
COG3525 Chb 1.47e-133 107 538 206 642
N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism].
cd06568 GH20_SpHex_like 1.22e-109 161 524 1 329
A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the active site plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. Proteins belonging to this subgroup lack the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases.
cd06570 GH20_chitobiase-like_1 4.72e-98 161 524 1 311
A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This subgroup lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.

CAZyme Hits      help

Created with Snap2754811081351621902172442712983253523804074344614885151542QRP58899.1|GH201542QQA09748.1|GH201542ASW16390.1|GH201542QQT79217.1|GH208543QUT74735.1|GH20
Hit ID E-Value Query Start Query End Hit Start Hit End
QRP58899.1 0.0 1 542 1 542
QQA09748.1 0.0 1 542 1 542
ASW16390.1 0.0 1 542 1 542
QQT79217.1 0.0 1 542 1 542
QUT74735.1 2.32e-268 8 543 10 544

PDB Hits      download full data without filtering help

Created with Snap275481108135162190217244271298325352380407434461488515205436Q63_A315407CBN_A735427DUP_A955243RCN_A735427DVB_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
6Q63_A 6.06e-236 20 543 22 541
BT0459[Bacteroides thetaiotaomicron],6Q63_B BT0459 [Bacteroides thetaiotaomicron],6Q63_C BT0459 [Bacteroides thetaiotaomicron]
7CBN_A 3.88e-127 31 540 14 512
Crystalstructure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila [Akkermansia muciniphila ATCC BAA-835],7CBO_A Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila in complex with GlcNAc [Akkermansia muciniphila ATCC BAA-835]
7DUP_A 1.86e-114 73 542 49 524
ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_A Chain A, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron]
3RCN_A 2.43e-114 95 524 67 498
CrystalStructure of Beta-N-Acetylhexosaminidase from Arthrobacter aurescens [Paenarthrobacter aurescens TC1]
7DVB_A 1.04e-113 73 542 49 524
ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_C Chain C, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_D Chain D, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron]

Swiss-Prot Hits      download full data without filtering help

Created with Snap27548110813516219021724427129832535238040743446148851529538sp|P49008|HEXA_PORGI31540sp|B2UQG6|H0868_AKKM8109505sp|P96155|HEX1_VIBFU90524sp|B2UP57|H2018_AKKM830533sp|Q7WUL4|HEX20_CELFI
Hit ID E-Value Query Start Query End Hit Start Hit End Description
P49008 1.01e-149 29 538 36 532
Beta-hexosaminidase OS=Porphyromonas gingivalis (strain ATCC BAA-308 / W83) OX=242619 GN=nahA PE=3 SV=2
B2UQG6 2.98e-126 31 540 33 531
Beta-hexosaminidase Amuc_0868 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_0868 PE=1 SV=1
P96155 1.64e-85 109 505 210 601
Beta-hexosaminidase OS=Vibrio furnissii OX=29494 GN=exoI PE=1 SV=1
B2UP57 1.63e-71 90 524 48 462
Beta-hexosaminidase Amuc_2018 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_2018 PE=1 SV=1
Q7WUL4 8.24e-67 30 533 6 472
Beta-N-acetylhexosaminidase OS=Cellulomonas fimi OX=1708 GN=hex20 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000000 0.000000 1.000043 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000054_01529.