CAZyme Information: MGYG000000099_01708

Basic Information

• Species: Flavonifractor plautii
• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Oscillospiraceae; Flavonifractor; Flavonifractor plautii
• CAZyme ID: MGYG000000099_01708
• CAZy Family: GH23
• CAZyme Description: DNA mismatch repair protein MutS

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
2733	MGYG000000099_2|CGC2	309943.23	4.7023

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000099	4030172	Isolate	Canada	North America

• Gene Location: Start: 579594; End: 587795 Strand: -

Full Sequence      

MARKYDFISELYNRTCKTVVANPASWEAFLRSACYNYRLRFDEQLLVHAQRPDATAVLQI
DDWNQKFGRWVNRGAHGIAVFEDADQRRQRLVHYFDISDTHPSRFSRRVPIWQMRDEYTA
EVIDTLESTFGELNDKETLAVAIESAARNAVEDNIPDYLSDLIYSVKDSFLDGVSEEEIT
HIFKTAVRNSVAYMTMTRLGIEAGEYFEPDDLRDVVNFTTPATLNALGYATSDIAEMGLA
EISRTILALDRQNRIIAEKTKADYNVGKEKPERSPDDERDHLHEAGGLSAPQSDNAGAAG
AVDGQVRPDAEEVPEGASQGTLLQPADELRPERASERHGAQSERAGTDADGADGSVGGRD
GESESDGYDELGSEDEQYPEPGSGDRDGGGNLRLDYYDRSHEDKSLPFFGGDDTVREILG
TTPHLKASKDEIRAFFEATADENARISYIKRIFNNDYTEVILSDGRRVGYKTYQNVLQLW
EGSYLSRTAQSFYDWGVIAQHFEAMRLLGELQDTMKPLPSIDGQLSLMTAGAEERKPSAF
AFSQEIIDAVLTRGSGISEGKMRIYEQFHKSLSAKENADFLKNEYGWGGVYPAIVGADID
EQHDGKGIRISKGIGSDKPHIDLKWSQVEKRIAELIKLDRYLNPKEKAQYPEWLQRQEER
RAELAEERRNREILSTAPSEKAEPKNERYEYHLGSTVYLGANEYEILSFDDERVMLYDTQ
FPLFNKEMTRTEFDSKVQENPLNDHLKVAIKQPEEKAVEYDIGMGYLGNGLTVWNRAVEV
NGDYQNIAHISPEGEITFYVQDLPQSVVERIEQAAEREKPKDAALPEFYQAYLKTKADNP
SSLLLYQVGDFFEAYADDAEVVGSALDLTQTTRAVDHNTRVPMVGFPQHRLETYLTMLTD
RGYDVAVNALEDGKRITRTVVSTTKEAPIESKPIGRIDYLGTDGKVGESIEYTSPYQFEK
DIKEENYYGVPMSIVLYKDKDGSTIPYDFVTRLDPPPKGFEIIDSPYLPENALDKAKHLI
DDFCREEYQREDGADYTDLNNVGIAYTTTEDDKHEIQARVNLVDFRIETLADGKVVRSEQ
YASLEELTEKGLQALSFDDLVYLSEEELAQVEAPLTPVWEHPKKSRVQSFDIHPEIPMAD
RHTFDLASHEVEEVNKKERFHRNYAAITVLKRCQEENRFATPDEQIILSKYVGWGGIPEA
FDERAGSWQTEFGMLKNILTPEEYASARESTLTAFYTPPTVINAVYKVMKQLGFREGNIL
EPSCGIGHFIGMLPEEMKESKIYGVELDTVSAGIAQQLYQKSSIAAQGFEETNLPDSFFD
AVVGNVPFGDFKVPDKRYEKHKFLIHDYFFAKSLDKLRPGGVMALITSKGTMDKENSAVR
KYIAQRADLLGAIRLPNNTFKGNAGTEVVSDILILQKRDRIVDIDPDWVQLGTDENGILM
NRYFVEHPEMILGEMKMVSGRFGPEATCVPYEGADLAEQLSEAVSNIHGELTVYEVEDEL
AEEDNSIPADPTVRNFSYTVLDDKIYFRENSRMAPVEVSATAENRIKGMIRIRDSVRKLI
ELQTEDYPDSEIQAEQERLNALYDTFSKQYGLINSRANISAFSQDSSFSLLSALEVLGDE
GQLERKADIFYKRTIKPHTPVTSVDTASEALAVSMGEKARVDMDYMCELTGKTEEEIFAD
LKGVIFLNPMHGYGNSTQAKYLMADEYLSGNVREKLVLARKSAELYPEDYTVNVEALERV
QPKDLTASEIAVRLGATWLPTEIVEQFMFEFLGTPRYAQWNIKVHFSAYTGEWNIEGKSY
DRSNVKAYSTYGTGRINSYKIIEETLNLKDVRIFDYVEDADGKKKAILNKKETAIAQAKQ
ELIKQGFQDWVWSDPERRERLCRLYNDKFNSLRPREYDGSHIVFSGMNPEIELREHQRNA
VAHILYGGNTLLAHAVGAGKTFEMVSAAMESKRLGLCSKSLFVVPNHLTEQWASEFLQLY
PSANILVATKKDFETKNRKKFCGRIATGDYDAIIIGHSQFEKIPMSIERQRAILEQQLDE
VTEGIAELKKNRGDNFSVKQLERTKKSVKQKLDKLNDQSKKDDTVTFEELGVDRLFIDES
HYYKNLFLFTKMRNVGGIAQTEAMKSSDLFMKCRYLDELTGGRGVVFATGTPISNSMVEL
YTIQRYLQYNTLVQNNLQHFDAWASTFGETITAVELTPEGTGYRAKTRFARFYNLPELMA
MFKEIADIKTADMLDLPVPKAVFHNISVKPSEIQRDMVAGLAERAERVRNGMVDARVDNM
LKITNDGRKLALDQRLINPLLPDFEDSKLNACVDAMFETWERGSEKRLTQLFFCDLSTPK
NDGSFNVYDDIRQKLIARGVPADEIKFIHEADTEAKKLELFKKVRRGDVRILMGSTQKMG
AGTNVQNKLAASSDLDCPWRPSDLEQRLGRSIRQGNENAEVHIYRFVTEETFDAYLYQLV
EGKQKFASQIMTSKSPVRSCEDIDETALSYAEIKMLATGNPHIKEKMDLDIQVQKLRLLK
SSFLSEKYALEDKIIKFYPQEIARRSDVIAGLKSDIERVAEHPKPSDETFVGMTVKGAFY
SEKADAGNAILEACKAMTNPEPIPLGEYRGFTMELYFEAREYKVRLKGELGYPVTLGTDT
FGNITRLDNALEGLPKRLEMNEMELDNIKKQFETAKVDVERPFPQEEELKAKTDRLNELN
ALLNVDKRENEIVGGEPDEGEELPEKKPKDLER

Enzyme Prediction     

No EC number prediction in MGYG000000099_01708.

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG4646	COG4646	1.93e-77	1440	1967	1	540	Adenine-specific DNA methylase, N12 class [Replication, recombination and repair].
COG4646	COG4646	1.13e-25	2110	2299	441	637	Adenine-specific DNA methylase, N12 class [Replication, recombination and repair].
pfam01624	MutS_I	1.30e-21	828	907	3	82	MutS domain I. This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.
COG0249	MutS	6.23e-18	823	921	4	102	DNA mismatch repair ATPase MutS [Replication, recombination and repair].
smart00487	DEXDc	1.75e-10	1911	2014	7	110	DEAD-like helicases superfamily.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ASV45029.1	0.0	1144	2668	1548	3156
QIW86704.1	0.0	1144	2710	1616	3265
QIW86628.1	0.0	1144	2710	1616	3265
AEY69616.1	2.65e-308	1157	2713	1702	3344
AXF51455.1	7.49e-306	1157	2713	1795	3437

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5AKB_A	1.18e-11	822	942	8	118	MutSin complex with the N-terminal domain of MutL - crystal form 1 [Escherichia coli K-12],5AKB_B MutS in complex with the N-terminal domain of MutL - crystal form 1 [Escherichia coli K-12],5AKB_E MutS in complex with the N-terminal domain of MutL - crystal form 1 [Escherichia coli K-12],5AKC_A MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_B MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_E MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_F MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_I MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_J MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKD_A MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_B MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_E MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_F MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_I MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_J MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12]
7AI6_A	1.22e-11	822	942	8	118	ChainA, DNA mismatch repair protein MutS [Escherichia coli K-12],7AI6_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7AIB_A Chain A, DNA mismatch repair protein MutS [Escherichia coli K-12],7AIB_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7AIC_A Chain A, DNA mismatch repair protein MutS [Escherichia coli K-12],7AIC_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12]
1OH5_A	1.55e-11	822	907	8	92	THECRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH [Escherichia coli],1OH5_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH [Escherichia coli],1OH6_A THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH [Escherichia coli],1OH6_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH [Escherichia coli],1OH7_A THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH [Escherichia coli],1OH7_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH [Escherichia coli],1OH8_A THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE [Escherichia coli],1OH8_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE [Escherichia coli],1W7A_A ATP bound MutS [Escherichia coli],1W7A_B ATP bound MutS [Escherichia coli],2WTU_A Crystal structure of Escherichia coli MutS in complex with a 16 basepair oligo containing an A.A mismatch. [Escherichia coli],2WTU_B Crystal structure of Escherichia coli MutS in complex with a 16 basepair oligo containing an A.A mismatch. [Escherichia coli],3ZLJ_A CRYSTAL STRUCTURE OF FULL-LENGTH E.COLI DNA MISMATCH REPAIR PROTEIN MUTS D835R MUTANT IN COMPLEX WITH GT MISMATCHED DNA [Escherichia coli K-12],3ZLJ_B CRYSTAL STRUCTURE OF FULL-LENGTH E.COLI DNA MISMATCH REPAIR PROTEIN MUTS D835R MUTANT IN COMPLEX WITH GT MISMATCHED DNA [Escherichia coli K-12]
3K0S_A	1.55e-11	822	907	7	91	ChainA, DNA mismatch repair protein mutS [Escherichia coli K-12],3K0S_B Chain B, DNA mismatch repair protein mutS [Escherichia coli K-12]
7OTO_A	1.55e-11	822	907	14	98	ChainA, DNA mismatch repair protein MutS [Escherichia coli K-12],7OTO_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7OU0_A Chain A, DNA mismatch repair protein MutS [Escherichia coli K-12],7OU0_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7OU4_A Chain A, DNA mismatch repair protein MutS [Escherichia coli],7OU4_B Chain B, DNA mismatch repair protein MutS [Escherichia coli]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q71TF8	9.97e-33	1231	2484	87	1567	Defense against restriction protein B OS=Escherichia phage P1 OX=2886926 GN=darB PE=3 SV=1
B8J008	2.07e-14	829	914	12	98	DNA mismatch repair protein MutS OS=Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB) OX=525146 GN=mutS PE=3 SV=1
A1VDD9	6.04e-12	825	914	8	98	DNA mismatch repair protein MutS OS=Desulfovibrio vulgaris subsp. vulgaris (strain DP4) OX=391774 GN=mutS PE=3 SV=1
P61666	6.04e-12	825	914	8	98	DNA mismatch repair protein MutS OS=Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) OX=882 GN=mutS PE=3 SV=1
Q67NK1	7.77e-12	824	928	6	119	DNA mismatch repair protein MutS OS=Symbiobacterium thermophilum (strain T / IAM 14863) OX=292459 GN=mutS PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000048	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000099_01708.