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CAZyme Information: MGYG000000101_01821
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Micrococcus luteus | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Micrococcaceae; Micrococcus; Micrococcus luteus | |||||||||||
| CAZyme ID | MGYG000000101_01821 | |||||||||||
| CAZy Family | CBM50 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 56979; End: 59042 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| smart00701 | PGRP | 1.09e-32 | 249 | 389 | 1 | 136 | Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine. |
| cd06583 | PGRP | 1.60e-19 | 273 | 390 | 2 | 111 | Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 kDa) extracellular proteins; intermediate PGRPs (PGRP-I) that are 40-45 kDa and are predicted to be transmembrane proteins; and long PGRPs (PGRP-L), up to 90 kDa, which may be either intracellular or transmembrane. Several structures of PGRPs are known in insects and mammals, some bound with substrates like Muramyl Tripeptide (MTP) or Tracheal Cytotoxin (TCT). The substrate binding site is conserved in PGRP-LCx, PGRP-LE, and PGRP-Ialpha proteins. This family includes Zn-dependent N-Acetylmuramoyl-L-alanine Amidase, EC:3.5.1.28. This enzyme cleaves the amide bond between N-acetylmuramoyl and L-amino acids, preferentially D-lactyl-L-Ala, in bacterial cell walls. The structure for the bacteriophage T7 lysozyme shows that two of the conserved histidines and a cysteine are zinc binding residues. Site-directed mutagenesis of T7 lysozyme indicates that two conserved residues, a Tyr and a Lys, are important for amidase activity. |
| PRK06347 | PRK06347 | 9.48e-15 | 468 | 684 | 332 | 589 | 1,4-beta-N-acetylmuramoylhydrolase. |
| pfam01510 | Amidase_2 | 9.68e-14 | 272 | 424 | 1 | 121 | N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding. |
| COG5479 | Psp3 | 9.15e-13 | 131 | 439 | 82 | 408 | Uncharacterized conserved protein, contains LGFP repeats [Function unknown]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QGY91018.1 | 0.0 | 1 | 687 | 1 | 687 |
| QGY84066.1 | 0.0 | 1 | 687 | 1 | 687 |
| QDW18172.1 | 0.0 | 1 | 687 | 1 | 687 |
| QQE49057.1 | 0.0 | 1 | 687 | 1 | 687 |
| QZY83833.1 | 0.0 | 1 | 687 | 1 | 691 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 5XZ4_A | 9.53e-11 | 249 | 369 | 8 | 123 | TheX-tay structure of Bumblebee PGRP-SA [Bombus],5XZ4_B The X-tay structure of Bumblebee PGRP-SA [Bombus] |
| 1YCK_A | 6.21e-10 | 251 | 369 | 12 | 126 | Crystalstructure of human peptidoglycan recognition protein (PGRP-S) [Homo sapiens] |
| 2RKQ_A | 3.46e-09 | 251 | 369 | 4 | 118 | Crystalstructure of drosophila peptidoglycan recognition protein SD (PGRP-SD) [Drosophila melanogaster] |
| 2F2L_X | 6.13e-09 | 251 | 426 | 3 | 153 | Crystalstructure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx) [Drosophila melanogaster] |
| 7NSX_AAA | 4.04e-06 | 251 | 384 | 17 | 146 | ChainAAA, Isoform A of Peptidoglycan-recognition protein LB [Drosophila melanogaster] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| O31852 | 9.35e-17 | 466 | 684 | 26 | 266 | D-gamma-glutamyl-meso-diaminopimelic acid endopeptidase CwlS OS=Bacillus subtilis (strain 168) OX=224308 GN=cwlS PE=1 SV=1 |
| Q6GJK9 | 6.24e-15 | 527 | 685 | 28 | 200 | N-acetylmuramoyl-L-alanine amidase sle1 OS=Staphylococcus aureus (strain MRSA252) OX=282458 GN=sle1 PE=3 SV=1 |
| Q70PU2 | 8.03e-15 | 251 | 426 | 24 | 173 | Peptidoglycan-recognition protein SC1a/b OS=Drosophila simulans OX=7240 GN=PGRP-SC1a PE=3 SV=1 |
| Q2G0U9 | 1.51e-14 | 527 | 685 | 28 | 200 | N-acetylmuramoyl-L-alanine amidase sle1 OS=Staphylococcus aureus (strain NCTC 8325 / PS 47) OX=93061 GN=sle1 PE=1 SV=1 |
| Q2FJH7 | 1.51e-14 | 527 | 685 | 28 | 200 | N-acetylmuramoyl-L-alanine amidase sle1 OS=Staphylococcus aureus (strain USA300) OX=367830 GN=sle1 PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.176537 | 0.790822 | 0.029040 | 0.002202 | 0.000765 | 0.000622 |