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CAZyme Information: MGYG000000111_00219

You are here: Home > Sequence: MGYG000000111_00219

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Cutibacterium acnes
Lineage Bacteria; Actinobacteriota; Actinomycetia; Propionibacteriales; Propionibacteriaceae; Cutibacterium; Cutibacterium acnes
CAZyme ID MGYG000000111_00219
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
372 MGYG000000111_1|CGC4 38324.16 7.4359
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000111 2484103 Isolate Canada North America
Gene Location Start: 226092;  End: 227210  Strand: +

Full Sequence      Download help

MVNVVLAGGG  TAGHTSPLIA  TAMALQERGA  TVSCIGTPRG  LEGRVIPEAG  LQLDMIPPVP60
LPRAINADLF  KVPARLAGAV  RKAGEVLQRR  QTDVVVGFGG  YVSLPAYLAA  RRAKIPVVIH120
EQNAVPGLAN  KIAARFAVFV  GTAFPDTPLP  KVRFVGMPLR  SQITDLADAS  GQARAERCAR180
ARADLGLDIN  RPTLLVSGGS  QGAVAINEAV  VAARTRLLAD  GVQILHVLGP  KNIREATRIT240
DELTGASWLP  VGYVDDMASA  YAAADLMVAR  SGAGTVVETA  TVGLPTIYVP  LPHGNGEQAR300
NATPAVDAGA  GVVVANADLD  AERLLAETAR  IHDADVLAQM  SAAGRGLMPA  HAAEEMAVRV360
ISAATSIDPT  IG372

Enzyme Prediction      help

No EC number prediction in MGYG000000111_00219.

CAZyme Signature Domains help

Created with Snap1837557493111130148167186204223241260279297316334353193346GT28
Family Start End Evalue family coverage
GT28 193 346 1.5e-42 0.9554140127388535

CDD Domains      download full data without filtering help

Created with Snap18375574931111301481671862042232412602792973163343531364murG4357GT28_MurG4357murG4357MurG4137Glyco_transf_28
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 2.98e-129 1 364 1 355
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 2.53e-107 4 357 2 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
TIGR01133 murG 8.27e-92 4 357 3 345
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0707 MurG 2.43e-91 4 357 3 348
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
pfam03033 Glyco_transf_28 1.71e-40 4 137 1 134
Glycosyltransferase family 28 N-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.

CAZyme Hits      help

Created with Snap18375574931111301481671862042232412602792973163343531372AER06583.1|GT281372ALU23188.1|GT281372ALD69420.1|GT281372AEH29091.1|GT281372AVT26293.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
AER06583.1 2.31e-258 1 372 1 372
ALU23188.1 2.31e-258 1 372 1 372
ALD69420.1 2.31e-258 1 372 1 372
AEH29091.1 1.23e-253 1 372 1 372
AVT26293.1 1.23e-253 1 372 1 372

PDB Hits      download full data without filtering help

Created with Snap183755749311113014816718620422324126027929731633435333313S2U_A93681F0K_A33457D1I_A1513114WYI_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 3.05e-47 3 331 4 321
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
1F0K_A 8.17e-47 9 368 14 358
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
7D1I_A 1.35e-43 3 345 11 347
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
4WYI_A 7.48e-06 151 311 179 333
Thecrystal structure of Arabidopsis thaliana galactolipid synthase, MGD1 (apo-form) [Arabidopsis thaliana],4X1T_A The crystal structure of Arabidopsis thaliana galactolipid synthase MGD1 in complex with UDP [Arabidopsis thaliana]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18375574931111301481671862042232412602792973163343531372sp|Q6A9Q2|MURG_CUTAK2357sp|A1SL80|MURG_NOCSJ3366sp|Q0RNP1|MURG_FRAAA3366sp|Q2JD50|MURG_FRACC2322sp|Q820F6|MURG_STRAW
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q6A9Q2 2.45e-254 1 372 1 372
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Cutibacterium acnes (strain DSM 16379 / KPA171202) OX=267747 GN=murG PE=3 SV=1
A1SL80 1.06e-116 2 357 1 352
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Nocardioides sp. (strain ATCC BAA-499 / JS614) OX=196162 GN=murG PE=3 SV=1
Q0RNP1 2.64e-104 3 366 4 365
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Frankia alni (strain ACN14a) OX=326424 GN=murG PE=3 SV=1
Q2JD50 2.01e-98 3 366 4 365
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3) OX=106370 GN=murG PE=3 SV=1
Q820F6 4.30e-97 2 322 1 315
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) OX=227882 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000060 0.000001 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000111_00219.