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CAZyme Information: MGYG000000111_01000

You are here: Home > Sequence: MGYG000000111_01000

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Cutibacterium acnes
Lineage Bacteria; Actinobacteriota; Actinomycetia; Propionibacteriales; Propionibacteriaceae; Cutibacterium; Cutibacterium acnes
CAZyme ID MGYG000000111_01000
CAZy Family GH20
CAZyme Description Beta-hexosaminidase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
512 MGYG000000111_2|CGC3 55699.06 5.4296
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000111 2484103 Isolate Canada North America
Gene Location Start: 169413;  End: 170951  Strand: -

Full Sequence      Download help

MPTNDTLIRG  LCPQPRQVQL  TEGQFPLPSV  LTWTGPDEVI  NVVTILTERL  APALDVVRAT60
SHTDDASLTV  TVDPALEAEG  YRIDIDTQVR  ITVGSPSGAR  WAVQTLLQLL  TPWVYGPGPL120
ALKHLCLPKG  VIVDAPHHSW  RGAHLDVSRH  FMPASFIMSF  LDVLAVHKLN  RLHLHLTDDQ180
GWRLPVPGWP  RLTTVGAWRP  GTVRGHQPPP  DDNGCDDVAE  HDHIPHGGAY  TVDQLRAIDE240
RAQLLGITVV  PEVDLPGHTE  SVVAAYPELG  CGAPISHPRT  AFGVSEHHIN  LTDAALGFCR300
DALDAVMEIF  PNSPIHIGGD  ECPGKEWFGH  KPTRTRLAEL  GITTPHQAQA  WFERQICGHV360
VAAGHQVIAW  DEVLEAGAPE  EVTVMVWRDA  DDIARAAAAG  HDVIAAPARH  TYLDHGMETG420
PQAPVTIDAP  MTMDDVAGLH  DVLAAVNSPH  LLGGQFQLWT  EYLCTPAQAE  DAAFPRGTSI480
AEQLWTGNPA  RPLSELEAQT  RRLTAMGVNW  HR512

Enzyme Prediction      help

EC 3.2.1.52

CAZyme Signature Domains help

Created with Snap255176102128153179204230256281307332358384409435460486134487GH20
Family Start End Evalue family coverage
GH20 134 487 1.3e-93 0.9703264094955489

CDD Domains      download full data without filtering help

Created with Snap255176102128153179204230256281307332358384409435460486138503GH20_chitobiase-like138487Glyco_hydro_2013486Chb139491GH20_SpHex_like140503GH20_chitobiase-like_1
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06563 GH20_chitobiase-like 2.80e-150 138 503 1 357
The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.
pfam00728 Glyco_hydro_20 9.41e-102 138 487 1 345
Glycosyl hydrolase family 20, catalytic domain. This domain has a TIM barrel fold.
COG3525 Chb 6.00e-88 13 486 138 614
N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism].
cd06568 GH20_SpHex_like 4.40e-61 139 491 2 320
A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the active site plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. Proteins belonging to this subgroup lack the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases.
cd06570 GH20_chitobiase-like_1 4.85e-54 140 503 3 311
A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This subgroup lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.

CAZyme Hits      help

Created with Snap2551761021281531792042302562813073323583844094354604861512AER05490.1|GH201512ALU22647.1|GH201512ALD68841.1|GH201512QAZ47724.1|GH201512AEW78177.1|GH20
Hit ID E-Value Query Start Query End Hit Start Hit End
AER05490.1 0.0 1 512 1 512
ALU22647.1 0.0 1 512 1 512
ALD68841.1 0.0 1 512 1 512
QAZ47724.1 0.0 1 512 1 512
AEW78177.1 0.0 1 512 1 512

PDB Hits      download full data without filtering help

Created with Snap255176102128153179204230256281307332358384409435460486115103RCN_A645127CBN_A795116Q63_A105027DUP_A105027DVB_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3RCN_A 8.79e-95 11 510 10 513
CrystalStructure of Beta-N-Acetylhexosaminidase from Arthrobacter aurescens [Paenarthrobacter aurescens TC1]
7CBN_A 1.72e-80 64 512 63 512
Crystalstructure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila [Akkermansia muciniphila ATCC BAA-835],7CBO_A Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila in complex with GlcNAc [Akkermansia muciniphila ATCC BAA-835]
6Q63_A 1.42e-75 79 511 106 529
BT0459[Bacteroides thetaiotaomicron],6Q63_B BT0459 [Bacteroides thetaiotaomicron],6Q63_C BT0459 [Bacteroides thetaiotaomicron]
7DUP_A 3.83e-71 10 502 5 508
ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_A Chain A, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron]
7DVB_A 2.06e-70 10 502 5 508
ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_C Chain C, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_D Chain D, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron]

Swiss-Prot Hits      download full data without filtering help

Created with Snap25517610212815317920423025628130733235838440943546048664512sp|B2UQG6|H0868_AKKM810511sp|P49008|HEXA_PORGI1481sp|P96155|HEX1_VIBFU74486sp|B2UP57|H2018_AKKM826511sp|Q7WUL4|HEX20_CELFI
Hit ID E-Value Query Start Query End Hit Start Hit End Description
B2UQG6 1.24e-79 64 512 82 531
Beta-hexosaminidase Amuc_0868 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_0868 PE=1 SV=1
P49008 1.60e-73 10 511 36 533
Beta-hexosaminidase OS=Porphyromonas gingivalis (strain ATCC BAA-308 / W83) OX=242619 GN=nahA PE=3 SV=2
P96155 1.25e-52 1 481 131 601
Beta-hexosaminidase OS=Vibrio furnissii OX=29494 GN=exoI PE=1 SV=1
B2UP57 1.07e-50 74 486 53 448
Beta-hexosaminidase Amuc_2018 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_2018 PE=1 SV=1
Q7WUL4 7.80e-40 26 511 8 478
Beta-N-acetylhexosaminidase OS=Cellulomonas fimi OX=1708 GN=hex20 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000046 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000111_01000.