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CAZyme Information: MGYG000000119_02199

You are here: Home > Sequence: MGYG000000119_02199

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Blautia sp000432195
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Blautia; Blautia sp000432195
CAZyme ID MGYG000000119_02199
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
740 MGYG000000119_13|CGC1 85556.3 5.3213
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000119 3510293 Isolate Canada North America
Gene Location Start: 78751;  End: 80973  Strand: -

Full Sequence      Download help

MGIIFHEQEK  TFHLYNKEVS  YIIRVMENGQ  LENLYYGKVI  RDRESFMHLH  EAISRPLTSV60
CVPEPGVLSM  EYTKQEYPVY  GTGDYRNPAL  SILQENGSRI  VNFTYVSHEI  YQGKKSLSPL120
PAVYTNNEHE  VCTLEICLHD  EVINTDLILS  YTMFEEYPVI  TRNAKLVHKG  EESIVLDRAL180
SMSVEFQDMD  FEMVHLSGAW  ARERYVKERK  LEMGIQAVQG  IHGTAGGAEH  NPFLALKRPD240
TTESQGEVYG  FSLVYSGNFL  AQTEVSTFDM  TRVLMGIHPE  GFHWKLETGE  SFQTPEVVMV300
YSDRGLNKMS  QVYHRLYRKN  LMRGQWKEQP  RPILLNNWEA  TYFDFTEEKI  LSIAKKAKEA360
GVELFVLDDG  WFGARNDDYR  GLGDWYVNLE  KLPDGIAGLS  RKVEEMGLKF  GLWVELEMVN420
KDSDLYRAHP  DWIVGVPERF  ESHGRHQHVL  DFSRKEVVDY  IYEMISKILR  ESRISYIKWD480
MNRYMSEPYS  RGLAAKDQGK  MMHRYILGVY  DLYTRLTEEF  PEILFESCAS  GGARFDPAML540
FFAPQTWTSD  DTDASERAKI  QYGTSYVYPL  VSMGSHVSAV  PNHQLLRITP  LSTRANMAYF600
GTFGYELDLN  LLSEEEMAQV  KEQVAFMKKY  RRLIQVEGDF  YRLLSPFKGN  ETAWIVVSPD660
KNQAVAAFYQ  KLNKINASWL  RFRLEGLDKD  TLYEVKCNDT  VYRAYGDELM  YAGIPVDREL720
LNKEGGDFAS  LLYVIEKAEP  740

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap377411114818522225929633337040744448151855559262966670312715GH36
Family Start End Evalue family coverage
GH36 12 715 7e-280 0.9956395348837209

CDD Domains      download full data without filtering help

Created with Snap37741111481852222592963333704074444815185555926296667039737GalA291635Melibiase330629GH3629287Glyco_hydro_36N651735Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 0.0 9 737 1 686
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 0.0 291 635 1 345
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 1.15e-148 330 629 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 4.05e-115 29 287 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 2.13e-24 651 735 1 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap37741111481852222592963333704074444815185555926296667031738AWY99321.1|GH361739QQR02711.1|GH361739ANU48401.1|GH361737QJU16496.1|GH361737QQQ95330.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
AWY99321.1 0.0 1 738 1 738
QQR02711.1 0.0 1 739 1 739
ANU48401.1 0.0 1 739 1 739
QJU16496.1 0.0 1 737 1 760
QQQ95330.1 0.0 1 737 1 760

PDB Hits      download full data without filtering help

Created with Snap377411114818522225929633337040744448151855559262966670317394FNQ_A17394FNR_A17394FNU_A17394FNT_A17394FNP_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNQ_A 2.77e-268 1 739 1 728
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 2.25e-267 1 739 1 728
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNU_A 2.09e-265 1 739 1 728
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNT_A 2.96e-265 1 739 1 728
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]
4FNP_A 4.20e-265 1 739 1 728
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap37741111481852222592963333704074444815185555926296667031739sp|Q9ALJ4|AGAA_GEOSE3733sp|G1UB44|MELA_LACAC1713sp|P43467|AGAL1_PEDPE1716sp|G4T4R7|AGASK_RUMGN10698sp|Q2TW69|AGALC_ASPOR
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 1.23e-266 1 739 1 728
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 3.30e-207 3 733 6 726
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 2.96e-197 1 713 1 710
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G4T4R7 3.65e-189 1 716 1 703
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
Q2TW69 2.42e-165 10 698 41 720
Probable alpha-galactosidase C OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=aglC PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000049 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000119_02199.