CAZyme Information: MGYG000000128_00049

Basic Information

• Species: Alistipes sp902363575
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Alistipes sp902363575
• CAZyme ID: MGYG000000128_00049
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
376		42722.3	9.7858

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000128	2906288	Isolate	Canada	North America

• Gene Location: Start: 55143; End: 56273 Strand: +

Full Sequence      

MKYYLIAGEPSGDLHGANLIDGLRKADPQAQFRFWGGDRMAAAGGAENLVRHYRETSFFG
IVQVIANLGTIRRQMRACREDLGAYAPDVLILVDYPGFNMKIARWAHERGIRTFYYIAPK
VWAWREHRVKAIRRYVDRLFIIFPFEREYFPRKGIEPVFEGNPLVDALAQRLPELPSPAE
FRARHGLDERPIVALLAGSRRSEIASNLPLMVRLAARFPDRLFVVTGVSWLDRAEYDRYL
AGSGVRYVCDQTYETLRAAEAAVVTSGTATLETALLGVPEVVVYRTLWLQVKLRPYVLKV
PYVSLVNLNLGRESVREIIQSSLEIGEAEQELRSILAGGAKRERMLRDFDELRTIIGGPG
ASERFARRMTDLLRHA

Enzyme Prediction     

No EC number prediction in MGYG000000128_00049.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	355	3e-104	0.9858757062146892

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	2.01e-102	1	374	2	376	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	1.17e-98	1	374	2	380	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	3.99e-70	4	364	2	366	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	2.22e-66	5	372	10	385	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	8.44e-41	1	369	2	344	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BBL06737.1	1.59e-215	1	374	1	374
AFL77950.1	1.44e-211	1	369	1	369
BBL11605.1	6.82e-210	1	374	1	374
BBL08813.1	6.82e-210	1	374	1	374
BBL00808.1	9.69e-210	1	374	1	374

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8N_A	4.63e-39	5	352	11	361	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]
5W8S_A	4.63e-39	5	352	11	361	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q74AT9	3.18e-67	2	373	8	380	Lipid-A-disaccharide synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) OX=243231 GN=lpxB PE=3 SV=1
Q1D393	1.72e-66	2	373	6	378	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
Q39T49	3.85e-65	2	373	8	380	Lipid-A-disaccharide synthase OS=Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) OX=269799 GN=lpxB PE=3 SV=1
Q2LVL8	1.26e-62	5	374	8	379	Lipid-A-disaccharide synthase OS=Syntrophus aciditrophicus (strain SB) OX=56780 GN=lpxB PE=3 SV=1
Q1INL4	3.14e-59	1	368	2	369	Lipid-A-disaccharide synthase OS=Koribacter versatilis (strain Ellin345) OX=204669 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000037	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000128_00049.