CAZyme Information: MGYG000000144_02017

Basic Information

• Species: Barnesiella intestinihominis
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Barnesiellaceae; Barnesiella; Barnesiella intestinihominis
• CAZyme ID: MGYG000000144_02017
• CAZy Family: GH33
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1146		124970.13	4.1886

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000144	3314966	Isolate	United Kingdom	Europe

• Gene Location: Start: 393052; End: 396492 Strand: +

Full Sequence      

MKKSVQFLLLFLMCISASWTWASDAPERTVLFNMGDYDSQYWRIPALVTAADNSLVAVVD
KRGSSLGDLPNTISIMSRRSTDNGKNWSEPVVVAQGGNGKTYGDPAVVLDKKTGNLICMF
VGDQGLWNATPYNRQGIYVSKSTDNGVSWSEPVAITDQVYANHSSWYAGFAGSGHGLCLK
DGRLMFVLAIRATSATGVPLHNYAIYSDDGGDNWTLSTNAATTAGDEAKVVELEDGDILM
SIRNPSKGNRIFCKSTDRGQTWGKAYFETELKDPACNGDIIRYSYSTDEGSEGKSRLLHS
LPESTTTRENVTIYLSEDDGETWPIKKRLVDGYSAYSSLTVLSDGTIGALVEEGKWDSNL
PGEDGFQLVFYRFTMDWLTSDVTEPPVVSEGTLQLNGTDRYMRIPSADDFNIAIGESYTV
TCKVKMPFSGSSCRFVSKRSYTGTANSGTVGWEMWGDMNASTRFSTNLSPAGSPWGGKGN
GTGVTFTENQWVHLTWVFDWNENTTNIYVDGVLGESKSLHADFQSKSLENNFDVLVGAGY
SNSDGSASIPAFFMNGEMDDLRFYNKALTLDEIKADMDATVDGTTDGLVAAYDFTDISGV
EVPDISGHGHTGTLVNFPNYSTLYTVTIAAPDPEQGTLKVMNGSTEVVSGTGIPENTRLT
VVAEPADGYQLKEIRVNDVALERNVNIFTLTQETTVTAEFEEAVPAYCTYEGNSSHDQRY
VRSITMNGGTSPFSVSVYSTTRQAVYVDKTDNVFEAYAGEEIQPVVNWAGEWMHGYLYID
YDKDYTFSYTLGSDDYPTADGELVSYTFYSPSDSQWGKNSKGETTENNSRLDDVPSFTLP
ESLAPGEYRVRLKIDWCHLDPCGHPDEIANTLTGNGGNIVDFTLRIVERPATYTVTLPET
VENGTLTVMNGSVALVPGANTVEENSELTITATPNKGYNLASLTVNGEDITSGETHTVTG
ATEISVTFEAKPTHTVTYSVVEGEGSIILTSADGTQSYESGEPIEAGTSFKITFDPAEDY
KVGRVMYGPSQFGAIMELTLASDNSYTMPAEQFVGNYTFEAYFVYDPETGIAENDREAIS
ARYVSGVLHVEGVTDGEFEVNIYNLTGKLVRTATETTVDVADLAKGCYLVKVTTAEAEKV
LKFIKE

Enzyme Prediction     

No EC number prediction in MGYG000000144_02017.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH33	29	356	7e-85	0.9415204678362573

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd15482	Sialidase_non-viral	7.25e-97	29	374	1	339	Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam13088	BNR_2	9.23e-26	73	348	18	279	BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
COG4409	NanH	6.49e-18	39	359	272	705	Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis].
pfam13859	BNR_3	9.81e-18	44	266	1	215	BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
pfam13385	Laminin_G_3	1.64e-13	396	574	1	151	Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BCI64112.1	0.0	1	1033	1	1037
QUT75110.1	1.66e-107	27	886	413	1035
SCM56345.1	3.83e-99	28	379	185	529
BBL05903.1	1.12e-98	8	379	9	378
BBD46557.1	3.97e-97	28	384	145	494

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1EUR_A	1.98e-43	42	354	25	346	Sialidase[Micromonospora viridifaciens],1EUS_A Sialidase Complexed With 2-Deoxy-2,3-Dehydro-N- Acetylneuraminic Acid [Micromonospora viridifaciens]
6MNJ_A	5.04e-43	35	352	193	521	Hadzamicrobial sialidase Hz136 [Alistipes],6MNJ_B Hadza microbial sialidase Hz136 [Alistipes]
7LBU_A	8.49e-42	41	361	93	423	ChainA, Exo-alpha-sialidase [Cutibacterium acnes],7LBV_A Chain A, Exo-alpha-sialidase [Cutibacterium acnes]
1W8N_A	1.52e-41	42	354	21	342	Contributionof the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora viridifaciens. [Micromonospora viridifaciens],1W8O_A Contribution of the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora viridifaciens [Micromonospora viridifaciens]
1EUT_A	1.61e-41	42	354	25	346	Sialidase,Large 68kd Form, Complexed With Galactose [Micromonospora viridifaciens],1EUU_A Sialidase Or Neuraminidase, Large 68kd Form [Micromonospora viridifaciens]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q02834	1.46e-40	42	354	67	388	Sialidase OS=Micromonospora viridifaciens OX=1881 GN=nedA PE=1 SV=1
P31206	3.30e-38	35	352	196	526	Sialidase OS=Bacteroides fragilis (strain YCH46) OX=295405 GN=nanH PE=3 SV=2
P15698	1.99e-27	1	352	1	380	Sialidase OS=Paeniclostridium sordellii OX=1505 PE=1 SV=1
Q4WQS0	1.39e-24	3	378	2	400	Exo-alpha-sialidase OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=AFUA_4G13800 PE=1 SV=2
D4B4P1	1.67e-21	42	378	61	402	Exo-alpha-sialidase ARB_03431 OS=Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) OX=663331 GN=ARB_03431 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000274	0.999027	0.000213	0.000156	0.000154	0.000145

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000144_02017.