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CAZyme Information: MGYG000000154_02312
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | RUG115 sp900066395 | |||||||||||
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| Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; RUG115; RUG115 sp900066395 | |||||||||||
| CAZyme ID | MGYG000000154_02312 | |||||||||||
| CAZy Family | GH36 | |||||||||||
| CAZyme Description | Alpha-galactosidase AgaA | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 443873; End: 446278 Strand: + | |||||||||||
Full Sequence Download help
| MIRKEKDYFI LDTDHTTYCF RVLPTGQLEH LYYGRKLHIE DEADMQPLVE KHVFAPGNVN | 60 |
| LYNEEQKAYS LEDMRLEMSS YGKGDIREPF VEVVNANGSN TIDFVYREAE ITKGKEAFAE | 120 |
| LPGSYGSEEE VEQLCIRLAD EGNELALELY YYVYPSCDII SRSAKFYNNG KKAVQLKRLM | 180 |
| SLQLDFDGHD YEFTTFHGAW AREMKRSDMP VIAGKLVNAS YTGTTSSRAN SFVMLSRPKT | 240 |
| TEDAGECFGF HLIYSGNHYE ATEVNSFGKM RLVTGINPQA FSYEVVPEES FQAPEAVMAY | 300 |
| AENGFNQMSQ RLHHFIREHI IRGTWQKKER PILLNSWEAS YFDISEKKLL KLAKEAKEVG | 360 |
| IELFVMDDGW FGERMDDSSS LGDWEANTKK LPGGLKGLSD KIHGLGLQFG IWVEPEMVNV | 420 |
| KSKLYVAHPD WTIEIPGQPH SEGRNQRILD LGRREVQDYI IESMSKVFSS ADISYVKWDM | 480 |
| NRTFSDYYST ALPPERQGEV AHRYVLGLYR CMRELTERFP EILFEGCAAG GNRFDLGILC | 540 |
| YFPQIWGSDD TDALCRAEIE ENYSYGYPLS AVSAHVSACP NHQTLRNTPL ETRFQVACFG | 600 |
| SFGYECNLCD MKKEEKEAMK EQIALYKKWR KVLQQGTFYR GRSFYDGAQS GMGGSVLADE | 660 |
| AGNQMEWTCV SEDGTKAVGM LMQKLVVPNT QQQTYYPKGL LPDVRYHFYN RKLKYNIKEF | 720 |
| GDLVNTVSPV HIRQDSLTHQ VLSKLVKMDG ETEDFHAYGD TLMYGGVHVS PAFGGTGYND | 780 |
| KVRHYPDFAS RLYFMDGEVK K | 801 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH36 | 9 | 719 | 3e-277 | 0.9854651162790697 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam02065 | Melibiase | 0.0 | 290 | 636 | 1 | 347 | Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27. |
| COG3345 | GalA | 7.98e-166 | 7 | 736 | 2 | 674 | Alpha-galactosidase [Carbohydrate transport and metabolism]. |
| cd14791 | GH36 | 1.74e-134 | 329 | 628 | 1 | 299 | glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively. |
| pfam16875 | Glyco_hydro_36N | 4.14e-106 | 26 | 284 | 1 | 254 | Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold. |
| cd14792 | GH27 | 1.22e-14 | 335 | 411 | 6 | 84 | glycosyl hydrolase family 27 (GH27). GH27 enzymes occur in eukaryotes, prokaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-N-acetylgalactosaminidase, and 3-alpha-isomalto-dextranase. All GH27 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH27 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AEN96404.1 | 0.0 | 1 | 798 | 1 | 799 |
| CBL09633.1 | 0.0 | 1 | 796 | 1 | 794 |
| CBL11721.1 | 0.0 | 1 | 796 | 1 | 794 |
| VCV21698.1 | 0.0 | 1 | 796 | 1 | 794 |
| QOS41139.1 | 0.0 | 1 | 796 | 1 | 778 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4FNR_A | 8.02e-196 | 9 | 700 | 12 | 684 | Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus] |
| 4FNT_A | 2.55e-194 | 9 | 700 | 12 | 684 | Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus] |
| 4FNP_A | 3.61e-194 | 9 | 700 | 12 | 684 | Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus] |
| 4FNU_A | 7.20e-194 | 9 | 700 | 12 | 684 | Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus] |
| 4FNQ_A | 4.06e-193 | 9 | 706 | 12 | 690 | Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q9ALJ4 | 4.39e-195 | 9 | 700 | 12 | 684 | Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1 |
| G1UB44 | 2.43e-174 | 9 | 706 | 15 | 693 | Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1 |
| P43467 | 1.98e-173 | 9 | 681 | 13 | 667 | Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1 |
| G4T4R7 | 2.36e-165 | 6 | 706 | 9 | 682 | Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1 |
| Q0CEF5 | 2.16e-150 | 9 | 640 | 18 | 638 | Probable alpha-galactosidase G OS=Aspergillus terreus (strain NIH 2624 / FGSC A1156) OX=341663 GN=aglG PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000046 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |