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CAZyme Information: MGYG000000174_00760
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Parabacteroides faecis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae; Parabacteroides; Parabacteroides faecis | |||||||||||
| CAZyme ID | MGYG000000174_00760 | |||||||||||
| CAZy Family | GH89 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 889050; End: 891269 Strand: - | |||||||||||
Full Sequence Download help
| MKYTFNLLLI LLLFFTSCRK DPQIQAAYDL IERITPGYGK QFCLELIGPD NGSDVYEVAG | 60 |
| ENGKVVLRGN NTVSLATAYN QYLKYHCNAH VSWFGDQLNL PETLPVPAET THRVINGKYR | 120 |
| VYFNYCTLSY TGAWWDWERW QREIDYMAMN SINTPLSVVG LEGVWYNTLL RFGFTDEEAR | 180 |
| SYLVDPAHFA WQWMPNIESF GGPLPKSWID SHIALGKQVV NRQLELGMTP IQQGFSGAVP | 240 |
| RKMMEKFPEA KIQKQPDWYG FEGICQLDPL DPLFTDLGKA FLEEEQKLYG TYGLYAADPF | 300 |
| HESKPPVDTP EYLNAVGSSI HKLMKTFDPD AMWVMQAWSF RKDIASVVPK HDLLVLSLNG | 360 |
| ALGGEDYFCN HDFVVGNLHN FGGRVNLHGD LPLVSSNQFM KAKQETPNVV GSGLFMESIG | 420 |
| QNPVFYELAF EMPVHQDSVK LKEWLDKYAQ RRYSAPSEAA GKAWELLLAG PYRAGTNGVE | 480 |
| SSSIICARPA VDVKKSGPNA GFNIPYDPQS LIEAEACLLQ DAEQLKGSKP YRFDIVDVQR | 540 |
| QIMSNLGQEI HKKAAEAFKK KDKEAFALHS GRFLELLKDV DILLRTRTEF NFDQWLTDAR | 600 |
| AWGTTDEERN LFEKNASSLV TIWGGQVDVR QFDYSWREWT GLIEGYYLQR WKQFYDMLQG | 660 |
| HLDNGTAYRE EDAKMDLGRQ AFRANEFYDS LADWELAFVD RPGKARTPVT EGDEVTVARR | 720 |
| MLDKYKQLSK EYYNVEKTN | 739 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH89 | 62 | 723 | 1.6e-205 | 0.995475113122172 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam05089 | NAGLU | 1.11e-146 | 120 | 433 | 1 | 330 | Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| pfam12972 | NAGLU_C | 1.10e-72 | 444 | 719 | 1 | 258 | Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. |
| pfam12971 | NAGLU_N | 6.63e-34 | 25 | 105 | 1 | 81 | Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QUT48266.1 | 0.0 | 7 | 736 | 6 | 735 |
| QQT79630.1 | 0.0 | 8 | 733 | 5 | 733 |
| QUT88879.1 | 0.0 | 25 | 733 | 26 | 734 |
| QUU09704.1 | 0.0 | 8 | 733 | 5 | 733 |
| ASM67128.1 | 0.0 | 8 | 733 | 5 | 733 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2VC9_A | 1.40e-113 | 41 | 666 | 189 | 832 | Family89 Glycoside Hydrolase from Clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin [Clostridium perfringens],2VCA_A Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine [Clostridium perfringens],2VCB_A Family 89 Glycoside Hydrolase from Clostridium perfringens in complex with PUGNAc [Clostridium perfringens],2VCC_A Family 89 Glycoside Hydrolase from Clostridium perfringens [Clostridium perfringens] |
| 7MFK_A | 1.66e-113 | 41 | 666 | 197 | 840 | ChainA, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124],7MFL_A Chain A, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124] |
| 4A4A_A | 1.72e-112 | 41 | 666 | 212 | 855 | CpGH89(E483Q, E601Q), from Clostridium perfringens, in complex with its substrate GlcNAc-alpha-1,4-galactose [Clostridium perfringens] |
| 4XWH_A | 2.97e-111 | 26 | 725 | 8 | 711 | Crystalstructure of the human N-acetyl-alpha-glucosaminidase [Homo sapiens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q9FNA3 | 3.07e-123 | 23 | 725 | 45 | 804 | Alpha-N-acetylglucosaminidase OS=Arabidopsis thaliana OX=3702 GN=NAGLU PE=2 SV=1 |
| P54802 | 4.08e-110 | 26 | 725 | 31 | 734 | Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as LIPO
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000004 | 0.002859 | 0.997169 | 0.000001 | 0.000001 | 0.000001 |