CAZyme Information: MGYG000000174_03611

Basic Information

• Species: Parabacteroides faecis
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae; Parabacteroides; Parabacteroides faecis
• CAZyme ID: MGYG000000174_03611
• CAZy Family: GH89
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
753	MGYG000000174_11|CGC1	85970.68	5.3934

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000174	6515019	Isolate	China	Asia

• Gene Location: Start: 156359; End: 158620 Strand: -

Full Sequence      

MKLKIALFILTIFCIGCTKDPQIRAAYDLIERVTPGYGKQFKLELIEPVDGQDAYEITSV
DGKVLLRGNNTVSLATAYNQYLKYTCNAHVSWFGDQLDLPEQLPLPEKEIKNTINGKYRV
YMNYCTVSYTAAWWDWDRWQRELDYMAMNSINMPLSVVGLEAVWYNTLLKYGFTDEEARA
FLAGPGHFAWQWMQNLQSYGGPLPKSWIDSHVELGKKVIDRQLELGMQPIQQGFSGYVPR
ELKNKYPDAKIQLQPSWCGFTGAAQLDPTDPLFSAFGRDFLEEEKRLFGAHGVYAADPFH
ESRPPVDTPEYLSAVGNSIYELFKNFDPSAMWVMQAWSLREPIVKAVPKEHLLILDLNGG
RSRQENTCWGYPVVAGNLHNFGGRINLHGDLRLLASNQYVLANRKSSNVCGSGLFMESIE
QNPVYYDLAFEIPLHIGEVDVEEWLGNYAKRRYGAISENAHRAWLYLLEGPYRPGTNGTE
RSSIIAARPALNVKKSGPNAGLGIPYSPLLVIRAQGLLLKDADNLKASAPYRFDVVDIQR
QLMSNLGQAIHKKAAEAFEKKDKAAFALHSSRFLEMLRDADILLRTRPEFNFDKWLTDAR
SWGTTGEEKDLLEKDATALVTIWGADGDPLIFDYSWREWSGLIDCYYLKRWEMFYAMLQE
HLDMGKDYSEKGLPMTHGREAFRANEFYSQLGDWELEFVSKTGKARTPVIQGDEIETVQK
MYKKYATLAREYYQDEMKADNIQEGNIFENLGE

Enzyme Prediction     

No EC number prediction in MGYG000000174_03611.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH89	61	724	1.2e-205	0.9969834087481146

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam05089	NAGLU	4.92e-155	119	433	1	330	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold.
pfam12972	NAGLU_C	3.18e-80	444	719	1	258	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold.
pfam12971	NAGLU_N	3.80e-34	24	104	1	81	Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QUT48266.1	0.0	1	753	1	752
QQT79630.1	0.0	1	753	1	752
QUU09704.1	0.0	1	753	1	752
ASM67128.1	0.0	1	753	1	752
QRP58487.1	0.0	1	753	1	752

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2VC9_A	2.13e-119	28	665	176	831	Family89 Glycoside Hydrolase from Clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin [Clostridium perfringens],2VCA_A Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine [Clostridium perfringens],2VCB_A Family 89 Glycoside Hydrolase from Clostridium perfringens in complex with PUGNAc [Clostridium perfringens],2VCC_A Family 89 Glycoside Hydrolase from Clostridium perfringens [Clostridium perfringens]
7MFK_A	2.56e-119	28	665	184	839	ChainA, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124],7MFL_A Chain A, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124]
4A4A_A	2.70e-118	28	665	199	854	CpGH89(E483Q, E601Q), from Clostridium perfringens, in complex with its substrate GlcNAc-alpha-1,4-galactose [Clostridium perfringens]
4XWH_A	3.54e-114	22	725	5	711	Crystalstructure of the human N-acetyl-alpha-glucosaminidase [Homo sapiens]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q9FNA3	3.01e-119	18	662	41	755	Alpha-N-acetylglucosaminidase OS=Arabidopsis thaliana OX=3702 GN=NAGLU PE=2 SV=1
P54802	4.91e-113	22	725	28	734	Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as LIPO

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000000	0.000000	1.000032	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000174_03611.