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CAZyme Information: MGYG000000202_01101
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | AF33-28 sp003477885 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; AF33-28; AF33-28 sp003477885 | |||||||||||
| CAZyme ID | MGYG000000202_01101 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | D-inositol-3-phosphate glycosyltransferase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 209330; End: 211357 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT4 | 498 | 642 | 1.9e-28 | 0.9375 |
| GT2 | 8 | 139 | 1.6e-24 | 0.7529411764705882 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd03825 | GT4_WcaC-like | 3.92e-103 | 273 | 673 | 2 | 364 | putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis. |
| cd06433 | GT_2_WfgS_like | 3.14e-71 | 8 | 209 | 1 | 202 | WfgS and WfeV are involved in O-antigen biosynthesis. Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families. |
| cd03801 | GT4_PimA-like | 8.22e-52 | 273 | 671 | 1 | 366 | phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. |
| cd03823 | GT4_ExpE7-like | 5.56e-39 | 273 | 671 | 1 | 356 | glycosyltransferase ExpE7 and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II). |
| COG0438 | RfaB | 7.35e-39 | 273 | 675 | 4 | 379 | Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QUO20810.1 | 5.38e-79 | 273 | 673 | 2 | 405 |
| ACI21875.1 | 1.51e-56 | 273 | 674 | 5 | 412 |
| BAY66036.1 | 4.71e-54 | 274 | 675 | 3 | 407 |
| QSV72541.1 | 2.08e-53 | 273 | 674 | 2 | 406 |
| AFZ46690.1 | 2.74e-53 | 273 | 674 | 2 | 404 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6KUW_A | 5.83e-15 | 489 | 675 | 233 | 427 | Crystalstructure of human alpha2C adrenergic G protein-coupled receptor. [Homo sapiens],6KUW_B Crystal structure of human alpha2C adrenergic G protein-coupled receptor. [Homo sapiens] |
| 2BFW_A | 1.24e-14 | 489 | 652 | 24 | 195 | Structureof the C domain of glycogen synthase from Pyrococcus abyssi [Pyrococcus abyssi] |
| 6E59_A | 4.76e-14 | 489 | 665 | 247 | 430 | Crystalstructure of the human NK1 tachykinin receptor [Homo sapiens] |
| 4S0V_A | 8.64e-14 | 489 | 665 | 280 | 463 | Crystalstructure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant [Homo sapiens] |
| 5WQC_A | 8.66e-14 | 489 | 665 | 281 | 464 | Crystalstructure of human orexin 2 receptor bound to the selective antagonist EMPA determined by the synchrotron light source at SPring-8. [Homo sapiens],5WS3_A Crystal structures of human orexin 2 receptor bound to the selective antagonist EMPA determined by serial femtosecond crystallography at SACLA [Homo sapiens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P71237 | 1.40e-19 | 274 | 628 | 3 | 361 | Putative colanic acid biosynthesis glycosyl transferase WcaC OS=Escherichia coli (strain K12) OX=83333 GN=wcaC PE=4 SV=2 |
| P71239 | 1.90e-17 | 7 | 209 | 3 | 204 | Putative colanic acid biosynthesis glycosyl transferase WcaE OS=Escherichia coli (strain K12) OX=83333 GN=wcaE PE=4 SV=2 |
| P9WMX7 | 1.35e-16 | 5 | 246 | 4 | 236 | PGL/p-HBAD biosynthesis glycosyltransferase Rv2957 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=Rv2957 PE=1 SV=1 |
| A1KMV1 | 1.35e-16 | 5 | 246 | 4 | 236 | PGL/p-HBAD biosynthesis glycosyltransferase BCG_2978 OS=Mycobacterium bovis (strain BCG / Pasteur 1173P2) OX=410289 GN=BCG_2978 PE=3 SV=2 |
| P9WMX6 | 1.35e-16 | 5 | 246 | 4 | 236 | PGL/p-HBAD biosynthesis glycosyltransferase MT3031 OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=MT3031 PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000055 | 0.000001 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |