CAZyme Information: MGYG000000221_01625

Basic Information

• Species: Parabacteroides bouchesdurhonensis
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae; Parabacteroides; Parabacteroides bouchesdurhonensis
• CAZyme ID: MGYG000000221_01625
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
781	MGYG000000221_5|CGC4	88380.73	8.4302

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000221	3481201	Isolate	China	Asia

• Gene Location: Start: 227124; End: 229469 Strand: +

Full Sequence      

MASRITKGVIISFWVIYVVALGAVALIFKLIADGSIGYMPPVEQLENPIDKYASQIISSD
GKTLGSYAHSKDNRIYVNYKDLSPDLVKALIATEDIRFTEHSGIDAQGLFRAIVKRGLLM
QKSGGGGSTITQQLAKQLFSPSADNIMERLFQKPIEWVIAVQLERNYTKEEIINMYLNKF
DFLYNAVGIQSAARVYFGKTPKMLKTEEAATLIGMCKNPSYFNPVRHNERTRGRRNTVLE
QMVKAGFLTQAECDSLKQTPLTVHFTRMDHKDGLAPYFREYLRLTLTAKKPERSNYASWQ
SQKFAEDSLSWATNPLYGWCNKNKKADGENYNIYTDGLKIYTTIDSRMQQYAEEAVRQHI
GNDLQPSFFKEKKGRSYAPFSRDVSVGQVDTMLIRAMHQTDRYRAMKSSGMNEADMRKEF
KKPVEMRVFSWDGPIDTIMSPWDSIRYHKSFLRSAFMSMDPRTGQVKAYVGGIDYNDFQY
DMVNGGRRQVGSTIKPFLYSLAMIEGFSPCDEMLHVQQQLMDENGRLWIPRNASAKRIGE
MVTIQWGLQNSDNWVTAYLMSQLSPYTFVRLLHSFGLKNYIDPVISVCLGTPDVSVGEMV
SAYTTFANKGIRVEPLYVTRIEDPYGNTIANFAPQMNEVLTEDASYKMLYMLRSVIDGGT
GGRVRFRYGIKAPMGGKTGTTQNNSDGWFIGFTPSLVSGCWVGGEDRSIHFDRLAEGQGA
SMALPIYGLYMQKVYADKTLGYSEEDTFEVPEQFSNPCENQSSRDTRNAPADIGGIDKMF
E

Enzyme Prediction     

No EC number prediction in MGYG000000221_01625.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	61	243	4.1e-59	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	2.07e-144	73	737	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.06e-140	10	771	14	631	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	5.24e-140	13	752	8	731	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	2.33e-80	55	732	49	782	penicillin-binding protein 1a; Provisional
TIGR02071	PBP_1b	2.68e-72	67	733	140	681	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QUT55103.1	0.0	1	781	1	781
ABR43557.1	0.0	1	781	1	781
QRO16257.1	0.0	1	781	1	781
QUT22137.1	0.0	1	781	1	781
QUT94447.1	0.0	1	781	1	781

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	8.76e-69	55	731	22	712	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	3.91e-66	42	740	9	728	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5U2G_A	3.81e-50	39	738	7	761	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
3ZG8_B	7.99e-41	162	703	2	431	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
5FGZ_A	2.85e-37	72	731	154	690	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	2.23e-75	39	780	30	706	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
O87579	1.02e-67	39	732	35	703	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
Q9KNU5	2.83e-67	44	737	43	760	Penicillin-binding protein 1A OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mrcA PE=3 SV=2
Q07806	2.49e-66	39	740	33	755	Penicillin-binding protein 1A OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=mrcA PE=1 SV=2
O87626	6.30e-66	39	731	35	701	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.966566	0.032050	0.000227	0.000158	0.000099	0.000920

TMHMM  Annotations     

start	end
9	31