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CAZyme Information: MGYG000000236_01126
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Bacteroides fragilis_A | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides fragilis_A | |||||||||||
| CAZyme ID | MGYG000000236_01126 | |||||||||||
| CAZy Family | GH20 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 20903; End: 23227 Strand: + | |||||||||||
Full Sequence Download help
| MRNLFKIAGL LALTGFISSC NDKETTANYQ VIPLPQEITT AQSQPFTLNG SVKIIYPEGN | 60 |
| EKMQRNAQFL ANYLKKATGK DYAVEAGTEG KGAILLKLGM ESENPEAYQL SVNADGVTIA | 120 |
| APTEAGVFYG IQTLRKSIPV AIGTTPSLPA VEINDYPRFS YRGAHFDVGR HFFTVDEVKT | 180 |
| YIDMMALHNM NRLHWHLTED QGWRLEIKKY PKLTEIGSKR SETVIGRNSG EYDGKPYGGF | 240 |
| YTQEEAKEIV AYAADRYITV IPEIDLPGHM QGALAAYPHL GCTGGPYEVW KIWGVSDQVL | 300 |
| CAGNDSVLTF IDDVLTEVME IFPSEYIHVG GDECPKTEWA KCPKCQARIK ALGIKSDAKH | 360 |
| SKEEYLQSFV INHAEKFLNE HGRQIIGWDE ILEGGLAPNA TVMSWRGEGG GIEAAKQKHD | 420 |
| VIMTPNTYLY FDYYQTKDTE NEPLAIGGYV PLERVYGYEP MPSSLTPDEQ KHIIGVQANL | 480 |
| WTEYIPTFAQ AQYMVLPRWA ALSEIQWSNP EKKNYDNFLS RLPQLISIYE AEGYNYAKHV | 540 |
| FDVKSEFVAN SATGAVDVVM TTIDGAPIHY TLDGTEPTAA SPVCDSILTI KESCTLKAVA | 600 |
| VRPTGNSKML TEKIAFSKST SKPIKANQPV NKQYEFGGVS TLVDGLKGNG NYKTGRWIAF | 660 |
| YKNDMDVTID LQQPTEISSV AITTCVEKGD WVFDARSFSI EVSDDDKTFT KVASEAYPEM | 720 |
| KETDRNGLYE HQLTFDPVKT RYVKVVATSE HSIPAWHGGK GNPGFLFVDE ITLN | 774 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH20 | 155 | 509 | 1.8e-125 | 0.9703264094955489 |
| CBM32 | 637 | 750 | 4.9e-17 | 0.75 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam00728 | Glyco_hydro_20 | 0.0 | 159 | 509 | 1 | 345 | Glycosyl hydrolase family 20, catalytic domain. This domain has a TIM barrel fold. |
| cd06563 | GH20_chitobiase-like | 0.0 | 159 | 522 | 1 | 357 | The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. |
| COG3525 | Chb | 2.26e-134 | 25 | 582 | 130 | 683 | N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]. |
| cd06568 | GH20_SpHex_like | 9.16e-114 | 159 | 522 | 1 | 329 | A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the active site plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. Proteins belonging to this subgroup lack the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. |
| cd06570 | GH20_chitobiase-like_1 | 6.86e-91 | 159 | 522 | 1 | 311 | A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This subgroup lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QRM70634.1 | 0.0 | 1 | 774 | 1 | 774 |
| AUI46168.1 | 0.0 | 1 | 774 | 1 | 774 |
| QKH84209.1 | 0.0 | 1 | 774 | 1 | 774 |
| BAC56900.2 | 0.0 | 1 | 774 | 1 | 774 |
| BAD48481.1 | 0.0 | 1 | 774 | 1 | 774 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6Q63_A | 0.0 | 1 | 774 | 1 | 774 | BT0459[Bacteroides thetaiotaomicron],6Q63_B BT0459 [Bacteroides thetaiotaomicron],6Q63_C BT0459 [Bacteroides thetaiotaomicron] |
| 3RCN_A | 2.61e-122 | 26 | 536 | 5 | 513 | CrystalStructure of Beta-N-Acetylhexosaminidase from Arthrobacter aurescens [Paenarthrobacter aurescens TC1] |
| 7CBN_A | 5.30e-120 | 32 | 538 | 14 | 512 | Crystalstructure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila [Akkermansia muciniphila ATCC BAA-835],7CBO_A Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila in complex with GlcNAc [Akkermansia muciniphila ATCC BAA-835] |
| 7DUP_A | 2.59e-115 | 33 | 540 | 8 | 524 | ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_A Chain A, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron] |
| 7DVB_A | 1.42e-114 | 33 | 540 | 8 | 524 | ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_C Chain C, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_D Chain D, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P49008 | 1.07e-154 | 31 | 623 | 37 | 624 | Beta-hexosaminidase OS=Porphyromonas gingivalis (strain ATCC BAA-308 / W83) OX=242619 GN=nahA PE=3 SV=2 |
| B2UQG6 | 4.05e-119 | 32 | 538 | 33 | 531 | Beta-hexosaminidase Amuc_0868 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_0868 PE=1 SV=1 |
| P96155 | 1.22e-80 | 67 | 503 | 170 | 601 | Beta-hexosaminidase OS=Vibrio furnissii OX=29494 GN=exoI PE=1 SV=1 |
| B2UP57 | 5.36e-72 | 106 | 522 | 58 | 462 | Beta-hexosaminidase Amuc_2018 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_2018 PE=1 SV=1 |
| Q7WUL4 | 8.06e-71 | 31 | 536 | 6 | 477 | Beta-N-acetylhexosaminidase OS=Cellulomonas fimi OX=1708 GN=hex20 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as LIPO
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000000 | 0.000000 | 1.000048 | 0.000000 | 0.000000 | 0.000000 |