dbCAN-seq: a database of CAZyme sequence and annotation

Basic Information help

Species

Blautia_A sp900066335

Lineage

Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Blautia_A; Blautia_A sp900066335

CAZyme ID

MGYG000000263_00206

CAZy Family

GH31

CAZyme Description

Oligosaccharide 4-alpha-D-glucosyltransferase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
663	MGYG000000263_1\|CGC2	76923.16	4.8128

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000263	3712893	Isolate	China	Asia

Gene Location

Start: 209093; End: 211084 Strand: -

Enzyme Prediction help

EC	3.2.1.20

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH31	133	613	9.1e-141	0.9953161592505855

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd06604	GH31_glucosidase_II_MalA	0.0	152	521	1	338	Alpha-glucosidase II-like. Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This subgroup also includes the MalA alpha-glucosidase from Sulfolobus solfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source.
pfam01055	Glyco_hydro_31	1.17e-176	133	610	1	439	Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.
COG1501	YicI	4.36e-128	44	656	149	716	Alpha-glucosidase, glycosyl hydrolase family GH31 [Carbohydrate transport and metabolism].
cd06603	GH31_GANC_GANAB_alpha	1.30e-109	152	614	1	427	neutral alpha-glucosidase C, neutral alpha-glucosidase AB. This subgroup includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae.
cd06602	GH31_MGAM_SI_GAA	8.01e-101	152	518	1	366	maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase. This subgroup includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes Pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII).

CAZyme Hits help

Hit ID	Query Start	Query End	Hit Start	Hit End
CBL19332.1	1	663	1	663
QCU03644.1	1	663	1	663
CBL22847.1	1	663	1	663
QRT48464.1	1	661	1	661
CBL25050.1	1	661	1	661

PDB Hits download full data without filtering help

Hit ID	Query Start	Query End	Hit Start	Hit End	Description
3M46_A	1	663	4	666	ChainA, Uncharacterized protein [Blautia obeum ATCC 29174],3M46_B Chain B, Uncharacterized protein [Blautia obeum ATCC 29174]
3NSX_A	1	663	4	666	ChainA, alpha-glucosidase [Blautia obeum ATCC 29174],3NSX_B Chain B, alpha-glucosidase [Blautia obeum ATCC 29174]
3N04_A	2	663	5	666	THECRYSTAL STRUCTURE OF THE alpha-Glucosidase (FAMILY 31) FROM RUMINOCOCCUS OBEUM ATCC 29174 [Blautia obeum ATCC 29174],3N04_B THE CRYSTAL STRUCTURE OF THE alpha-Glucosidase (FAMILY 31) FROM RUMINOCOCCUS OBEUM ATCC 29174 [Blautia obeum ATCC 29174]
3M6D_A	1	663	4	666	ChainA, Uncharacterized protein [Blautia obeum ATCC 29174],3M6D_B Chain B, Uncharacterized protein [Blautia obeum ATCC 29174],3MKK_A Chain A, alpha-glucosidase GH31 family [Blautia obeum ATCC 29174],3MKK_B Chain B, alpha-glucosidase GH31 family [Blautia obeum ATCC 29174],3POC_A The crystal structure of the D307A mutant of alpha-Glucosidase (FAMILY 31) from Ruminococcus obeum ATCC 29174 in complex with acarbose [Blautia obeum ATCC 29174],3POC_B The crystal structure of the D307A mutant of alpha-Glucosidase (FAMILY 31) from Ruminococcus obeum ATCC 29174 in complex with acarbose [Blautia obeum ATCC 29174]
3NUK_A	1	663	4	666	ChainA, ALPHA-GLUCOSIDASE [Blautia obeum ATCC 29174],3NUK_B Chain B, ALPHA-GLUCOSIDASE [Blautia obeum ATCC 29174],3PHA_A The crystal structure of the W169Y mutant of alpha-glucosidase (gh31 family) from Ruminococcus obeum atcc 29174 in complex with acarbose [Blautia obeum ATCC 29174],3PHA_B The crystal structure of the W169Y mutant of alpha-glucosidase (gh31 family) from Ruminococcus obeum atcc 29174 in complex with acarbose [Blautia obeum ATCC 29174],3PHA_C The crystal structure of the W169Y mutant of alpha-glucosidase (gh31 family) from Ruminococcus obeum atcc 29174 in complex with acarbose [Blautia obeum ATCC 29174],3PHA_D The crystal structure of the W169Y mutant of alpha-glucosidase (gh31 family) from Ruminococcus obeum atcc 29174 in complex with acarbose [Blautia obeum ATCC 29174],6C9Z_A Chain A, Glycosyl hydrolase, family 31 [Blautia obeum ATCC 29174],6C9Z_B Chain B, Glycosyl hydrolase, family 31 [Blautia obeum ATCC 29174],6CA3_A Chain A, Glycosyl hydrolase, family 31 [Blautia obeum ATCC 29174],6CA3_B Chain B, Glycosyl hydrolase, family 31 [Blautia obeum ATCC 29174]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q9F234	1.49e-124	23	660	123	724	Alpha-glucosidase 2 OS=Bacillus thermoamyloliquefaciens OX=1425 PE=3 SV=1
P0CD66	1.30e-81	2	641	12	632	Alpha-glucosidase OS=Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) OX=273057 GN=malA PE=1 SV=1
D0KQM8	1.51e-81	2	641	12	632	Alpha-glucosidase OS=Saccharolobus solfataricus (strain 98/2) OX=555311 GN=malA PE=1 SV=1
O04893	4.10e-79	50	570	203	715	Alpha-glucosidase OS=Spinacia oleracea OX=3562 PE=1 SV=1
Q653V7	2.06e-76	130	570	264	691	Probable alpha-glucosidase Os06g0675700 OS=Oryza sativa subsp. japonica OX=39947 GN=Os06g0675700 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000060	0.000002	0.000000	0.000000	0.000000	0.000000

TMHMM Annotations help

There is no transmembrane helices in MGYG000000263_00206.

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