CAZyme Information: MGYG000000264_02626

Basic Information

• Species: Exiguobacterium sp003467445
• Lineage: Bacteria; Firmicutes; Bacilli; Exiguobacterales; Exiguobacteraceae; Exiguobacterium; Exiguobacterium sp003467445
• CAZyme ID: MGYG000000264_02626
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 4

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
595	MGYG000000264_12|CGC1	65848.35	8.5836

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000264	2830712	Isolate	China	Asia

• Gene Location: Start: 47023; End: 48810 Strand: +

Full Sequence      

MRAWLGTVFFVGLLAVGGTISGALKEEIEQAQQILTWGENKVEATPLASKHAVTLTYKGG
SERLYLSGRRDDVSVARLPAHLREAIMTIEDRKFNAHPGYDLGGIARAFINNANESSRQG
GSTITQQLARNVYLTHERTYERKVKELLLARALEKQYSKKEIITAYSNVIFFGHNVYGIQ
AAAETYFARPLEDLNWNQIAFLLTVPNNPSLYDPLDPSESFYARKDRILTQLRDAGVISR
QAYDTHHGVKLTATYRQHVVRYPDYMDTVIKEAIRLVRSRYDLDEEAARDYLATNQATIE
THLSVARQQRAKQVMTKLPNGLNGGYAELTPNGRIIALVDSDMIQSGEFNRATQAFRQPG
SAIKPVLVFAPYIEETGAKLDTILDGRPVCYGTYCPTNSGNRVLGDVSFRDTVAYSYNTP
ALAAFTAIDQEAAYATADMMFSQWDSKTDNSLASALGGLTQGVSPKELAAAYTPFLNQGV
YVSGQTIKQIRFESGAATITPSMTKQTVWSKATVATMREALSAVTTYGTGRYANQIKASY
IGGKTGTTNSHKDMWYVGLTDETITAIWLGADTPRPFPELANRAYPAIVWTEAHR

Enzyme Prediction     

No EC number prediction in MGYG000000264_02626.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	68	232	8.1e-59	0.9322033898305084

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	1.81e-131	2	593	12	592	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	1.48e-124	69	576	1	506	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	4.60e-94	65	576	62	696	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	5.41e-70	69	233	12	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
COG4953	PbpC	1.07e-59	73	570	61	534	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QUE86084.1	0.0	1	595	9	603
QPI67072.1	0.0	1	595	1	596
ACQ71353.1	0.0	1	595	1	596
QUP86532.1	0.0	1	595	1	596
AHA28978.1	2.14e-167	1	590	1	585

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	1.10e-44	73	588	42	702	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	7.64e-44	69	589	38	710	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3ZG8_B	2.46e-43	151	572	1	433	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	1.16e-39	151	572	1	433	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
5U2G_A	1.12e-36	69	495	39	560	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P40750	1.21e-100	77	590	83	616	Penicillin-binding protein 4 OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpD PE=1 SV=2
P38050	6.24e-71	70	592	67	592	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
A0A0H2ZMF9	1.12e-58	66	573	106	625	Penicillin-binding protein 2a OS=Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) OX=373153 GN=pbp2a PE=1 SV=1
Q8DNB6	1.12e-58	66	573	106	625	Penicillin-binding protein 2a OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=pbp2a PE=1 SV=1
P39793	1.16e-58	7	570	37	613	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.055331	0.938207	0.005383	0.000386	0.000320	0.000352

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000264_02626.