dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000000298_00913

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Basic Information help

Species

Lineage

Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus;

CAZyme ID

MGYG000000298_00913

CAZy Family

GH66

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1322		144677.58	4.771

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000298	1627980	MAG	Sweden	Europe

Gene Location

Start: 7726; End: 11694 Strand: +

Full Sequence Download help

Enzyme Prediction help

EC	3.2.1.11

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH66	124	729	2.4e-104	0.9946043165467626

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd14745	GH66	3.40e-100	214	575	1	331	Glycoside Hydrolase Family 66. Glycoside Hydrolase Family 66 contains proteins characterized as cycloisomaltooligosaccharide glucanotransferase (CITase) and dextranases from a variety of bacteria. CITase cyclizes part of a (1-6)-alpha-D-glucan (dextrans) chain by formation of a (1-6)-alpha-D-glucosidic bond. Dextranases catalyze the endohydrolysis of (1-6)-alpha-D-glucosidic linkages in dextran. Some members contain Carbohydrate Binding Module 35 (CBM35) domains, either C-terminal or inserted in the domain or both.
pfam13199	Glyco_hydro_66	6.12e-90	127	727	1	557	Glycosyl hydrolase family 66. This family is a set of glycosyl hydrolase enzymes including cycloisomaltooligosaccharide glucanotransferase (EC:2.4.1.-) and dextranase (EC:3.2.1.11) activities.
pfam17965	MucBP_2	1.17e-12	734	810	3	73	Mucin binding domain. This domain is found in bacterial cell surface proteins that interact with mucins. The archetypal member of this family is the Mub-R5 B1 domain. This domain has a beta-grasp fold.
pfam17966	Mub_B2	7.03e-11	859	927	3	66	Mub B2-like domain. This entry corresponds to the Mub B2 domain. This domain is related to the Mub B1 domain pfam17965. This domain may be involved in mucin binding. This domain is often found associated with the related pfam17965 in bacterial cell surface proteins.
TIGR01167	LPXTG_anchor	7.78e-04	1289	1322	1	34	LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QLF55758.1	0.0	1	1322	1	1345
QKI21846.1	3.22e-160	125	744	13	635
ASK26976.1	8.24e-140	152	627	2	462
AWN64322.1	1.71e-81	124	728	161	795
AWN62447.1	1.71e-81	124	728	161	795

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3VMN_A	8.83e-75	124	728	10	635	Crystalstructure of dextranase from Streptococcus mutans [Streptococcus mutans],3VMO_A Crystal structure of dextranase from Streptococcus mutans in complex with isomaltotriose [Streptococcus mutans],3VMP_A Crystal structure of dextranase from Streptococcus mutans in complex with 4,5-epoxypentyl alpha-D-glucopyranoside [Streptococcus mutans]
5AXG_A	1.15e-35	120	729	42	609	Crystalstructure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus [Thermoanaerobacter pseudethanolicus ATCC 33223],5AXG_B Crystal structure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus [Thermoanaerobacter pseudethanolicus ATCC 33223]
5AXH_A	8.70e-35	120	729	42	609	Crystalstructure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus, D312G mutant in complex with isomaltohexaose [Thermoanaerobacter pseudethanolicus ATCC 33223],5AXH_B Crystal structure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus, D312G mutant in complex with isomaltohexaose [Thermoanaerobacter pseudethanolicus ATCC 33223]
3WNK_A	6.21e-17	129	728	34	721	ChainA, Cycloisomaltooligosaccharide glucanotransferase [Niallia circulans]
3WNP_A	8.03e-17	129	728	15	702	ChainA, Cycloisomaltooligosaccharide glucanotransferase [Niallia circulans],3WNP_B Chain B, Cycloisomaltooligosaccharide glucanotransferase [Niallia circulans]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q59979	3.98e-81	151	749	4	620	Dextranase OS=Streptococcus salivarius OX=1304 GN=dex PE=3 SV=1
P39653	6.54e-81	124	728	165	800	Dextranase OS=Streptococcus downei OX=1317 GN=dex PE=1 SV=1
Q54443	1.31e-72	124	728	107	732	Dextranase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=dexA PE=1 SV=2
P94286	9.63e-18	129	773	51	790	Cycloisomaltooligosaccharide glucanotransferase OS=Niallia circulans OX=1397 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.006467	0.991016	0.001825	0.000286	0.000208	0.000173

TMHMM Annotations download full data without filtering help

start	end
21	40
1300	1317