dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000000343_02261

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Basic Information help

Species

Odoribacter sp900548135

Lineage

Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Marinifilaceae; Odoribacter; Odoribacter sp900548135

CAZyme ID

MGYG000000343_02261

CAZy Family

GH33

CAZyme Description

Arylsulfatase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
473		52435.35	6.8755

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000343	3841231	MAG	Sweden	Europe

Gene Location

Start: 48193; End: 49614 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000000343_02261.

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd16026	GALNS_like	0.0	25	429	3	399	galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS). Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
cd16144	ARS_like	9.11e-124	25	441	2	416	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16143	ARS_like	8.49e-122	25	429	2	395	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16142	ARS_like	5.87e-120	25	428	2	371	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16146	ARS_like	4.87e-119	25	439	2	397	uncharacterized arylsulfatase. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
VTR91273.1	4.55e-163	1	473	1	476
VTS00049.1	1.04e-156	1	470	1	477
AWM40795.1	1.04e-156	1	470	1	477
QEG25923.1	1.04e-156	1	470	1	477
QNN23223.1	2.64e-103	25	450	34	429

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1E1Z_P	3.38e-76	25	447	4	442	Crystalstructure of an Arylsulfatase A mutant C69S [Homo sapiens]
1E3C_P	3.38e-76	25	447	4	442	Crystalstructure of an Arylsulfatase A mutant C69S soaked in synthetic substrate [Homo sapiens]
1E2S_P	9.38e-76	25	447	4	442	Crystalstructure of an Arylsulfatase A mutant C69A [Homo sapiens]
1AUK_A	1.85e-75	25	447	4	442	HumanArylsulfatase A [Homo sapiens],1N2K_A Crystal structure of a covalent intermediate of endogenous human arylsulfatase A [Homo sapiens],1N2L_A Crystal structure of a covalent intermediate of endogenous human arylsulfatase A [Homo sapiens]
1E33_P	1.85e-75	25	447	4	442	Crystalstructure of an Arylsulfatase A mutant P426L [Homo sapiens]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P50428	2.09e-79	25	447	21	459	Arylsulfatase A OS=Mus musculus OX=10090 GN=Arsa PE=1 SV=2
Q571E4	1.26e-77	7	450	10	477	N-acetylgalactosamine-6-sulfatase OS=Mus musculus OX=10090 GN=Galns PE=1 SV=2
Q32KJ6	1.50e-76	6	450	13	481	N-acetylgalactosamine-6-sulfatase OS=Rattus norvegicus OX=10116 GN=Galns PE=1 SV=1
Q32KH5	5.54e-76	5	450	12	479	N-acetylgalactosamine-6-sulfatase OS=Canis lupus familiaris OX=9615 GN=GALNS PE=2 SV=1
P15289	1.60e-74	25	447	22	460	Arylsulfatase A OS=Homo sapiens OX=9606 GN=ARSA PE=1 SV=3

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000217	0.999156	0.000161	0.000170	0.000149	0.000140

TMHMM Annotations help

There is no transmembrane helices in MGYG000000343_02261.