You are browsing environment: HUMAN GUT
CAZyme Information: MGYG000000356_01285
You are here: Home > Sequence: MGYG000000356_01285
Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; VUNI01; | |||||||||||
| CAZyme ID | MGYG000000356_01285 | |||||||||||
| CAZy Family | CE17 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
|
|||||||||||
| Genome Property |
|
|||||||||||
| Gene Location | Start: 98298; End: 100367 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| CE17 | 37 | 199 | 1.3e-79 | 0.9878787878787879 |
| CBM35inCE17 | 225 | 369 | 2.2e-61 | 0.9664429530201343 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| COG1482 | ManA | 8.86e-105 | 381 | 685 | 2 | 306 | Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]. |
| TIGR00218 | manA | 1.35e-88 | 383 | 687 | 2 | 301 | mannose-6-phosphate isomerase, class I. The names phosphomannose isomerase and mannose-6-phosphate isomerase are synonomous. This family contains two rather deeply branched groups. One group contains an experimentally determined phosphomannose isomerase of Streptococcus mutans as well as three uncharacterized paralogous proteins of Bacillus subtilis, all at more than 50 % identity to each other, plus a more distant homolog from Archaeoglobus fulgidus. The other group contains members from E. coli, budding yeast, Borrelia burgdorferi, etc. [Energy metabolism, Sugars] |
| cd07010 | cupin_PMI_type_I_N_bac | 1.57e-78 | 393 | 594 | 7 | 172 | Phosphomannose isomerase in bacteria and archaea, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in many bacteria (e.g. Bacillus subtilis) and archaea. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily does not contain an alpha helical domain that exists in eukaryotic and some prokaryotic PMIs. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death. |
| pfam01238 | PMI_typeI | 1.04e-44 | 382 | 688 | 1 | 372 | Phosphomannose isomerase type I. This is a family of Phosphomannose isomerase type I enzymes (EC 5.3.1.8). |
| pfam13472 | Lipase_GDSL_2 | 4.30e-19 | 37 | 199 | 1 | 174 | GDSL-like Lipase/Acylhydrolase family. This family of presumed lipases and related enzymes are similar to pfam00657. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CBL10432.1 | 1.53e-176 | 1 | 370 | 1 | 369 |
| CBL12377.1 | 1.53e-176 | 1 | 370 | 1 | 369 |
| EEV02614.1 | 2.17e-176 | 1 | 370 | 1 | 369 |
| BCN32107.1 | 4.88e-167 | 1 | 368 | 1 | 368 |
| AEN97393.1 | 2.03e-156 | 376 | 688 | 454 | 766 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6HH9_A | 4.90e-178 | 1 | 376 | 1 | 374 | Crystalstructure of a two-domain esterase (CEX) active on acetylated mannans co-crystallized with mannopentaose [Roseburia intestinalis L1-82],6HH9_B Crystal structure of a two-domain esterase (CEX) active on acetylated mannans co-crystallized with mannopentaose [Roseburia intestinalis L1-82],6HH9_C Crystal structure of a two-domain esterase (CEX) active on acetylated mannans co-crystallized with mannopentaose [Roseburia intestinalis L1-82],6HH9_D Crystal structure of a two-domain esterase (CEX) active on acetylated mannans co-crystallized with mannopentaose [Roseburia intestinalis L1-82] |
| 6HFZ_A | 1.18e-173 | 3 | 376 | 3 | 374 | Crystalstructure of a two-domain esterase (CEX) active on acetylated mannans [Roseburia intestinalis L1-82],6HFZ_B Crystal structure of a two-domain esterase (CEX) active on acetylated mannans [Roseburia intestinalis L1-82],6HFZ_C Crystal structure of a two-domain esterase (CEX) active on acetylated mannans [Roseburia intestinalis L1-82],6HFZ_D Crystal structure of a two-domain esterase (CEX) active on acetylated mannans [Roseburia intestinalis L1-82] |
| 1QWR_A | 2.18e-93 | 375 | 687 | 1 | 317 | CrystalStructure Analysis of the Mannose 6-Phosphate Isomerase from Bacillus subtilis [Bacillus subtilis],1QWR_B Crystal Structure Analysis of the Mannose 6-Phosphate Isomerase from Bacillus subtilis [Bacillus subtilis] |
| 1ZX5_A | 3.96e-12 | 389 | 569 | 15 | 194 | Thestructure of a putative mannosephosphate isomerase from Archaeoglobus fulgidus [Archaeoglobus fulgidus] |
| 3W7V_A | 4.79e-08 | 26 | 203 | 2 | 204 | CrystalStructure of Axe2, an Acetylxylan Esterase from Geobacillus stearothermophilus [Geobacillus stearothermophilus],3W7V_B Crystal Structure of Axe2, an Acetylxylan Esterase from Geobacillus stearothermophilus [Geobacillus stearothermophilus] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| O31646 | 3.16e-95 | 381 | 687 | 4 | 313 | Mannose-6-phosphate isomerase ManA OS=Bacillus subtilis (strain 168) OX=224308 GN=manA PE=2 SV=1 |
| Q59935 | 9.94e-94 | 381 | 687 | 3 | 311 | Mannose-6-phosphate isomerase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=pmi PE=3 SV=2 |
| P39841 | 1.40e-93 | 383 | 687 | 6 | 314 | Putative mannose-6-phosphate isomerase YvyI OS=Bacillus subtilis (strain 168) OX=224308 GN=yvyI PE=1 SV=1 |
| O05511 | 2.05e-88 | 383 | 687 | 5 | 313 | Probable mannose-6-phosphate isomerase GmuF OS=Bacillus subtilis (strain 168) OX=224308 GN=gmuF PE=1 SV=1 |
| Q09LX1 | 2.62e-07 | 26 | 203 | 2 | 204 | Acetylxylan esterase OS=Geobacillus stearothermophilus OX=1422 GN=axe2 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000058 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |