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CAZyme Information: MGYG000000394_00468
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Alphaproteobacteria; RF32; CAG-239; CAG-495; | |||||||||||
| CAZyme ID | MGYG000000394_00468 | |||||||||||
| CAZy Family | CE11 | |||||||||||
| CAZyme Description | UDP-3-O-acyl-N-acetylglucosamine deacetylase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 992; End: 1843 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| CE11 | 2 | 274 | 6.6e-97 | 0.992619926199262 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK13186 | lpxC | 9.86e-140 | 1 | 283 | 3 | 282 | UDP-3-O-acyl-N-acetylglucosamine deacetylase. |
| pfam03331 | LpxC | 8.19e-133 | 2 | 275 | 1 | 271 | UDP-3-O-acyl N-acetylglycosamine deacetylase. The enzymes in this family catalyze the second step in the biosynthetic pathway for lipid A. |
| COG0774 | LpxC | 5.37e-117 | 1 | 283 | 3 | 285 | UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell wall/membrane/envelope biogenesis]. |
| TIGR00325 | lpxC | 1.83e-89 | 1 | 283 | 2 | 281 | UDP-3-0-acyl N-acetylglucosamine deacetylase. UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase from E. coli , LpxC, was previously designated EnvA. This enzyme is involved in lipid-A precursor biosynthesis. It is essential for cell viability. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides] |
| PRK13188 | PRK13188 | 2.28e-82 | 1 | 273 | 4 | 298 | bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AVM80170.1 | 4.81e-78 | 2 | 278 | 29 | 307 |
| AVM76267.1 | 4.81e-78 | 2 | 278 | 29 | 307 |
| AWK87523.1 | 8.99e-78 | 2 | 278 | 13 | 288 |
| QDO99764.1 | 9.56e-78 | 2 | 280 | 3 | 279 |
| CDK99719.1 | 1.36e-77 | 2 | 278 | 29 | 307 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 5U39_A | 1.18e-61 | 2 | 283 | 6 | 286 | Pseudomonasaeruginosa LpxC in complex with CHIR-090 [Pseudomonas aeruginosa PAO1] |
| 4J3D_A | 1.25e-61 | 2 | 283 | 4 | 284 | Pseudomonasaeruginosa LpxC in complex with a hydroxamate inhibitor [Pseudomonas aeruginosa PAO1],4J3D_B Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor [Pseudomonas aeruginosa PAO1] |
| 5U3B_A | 1.33e-61 | 2 | 283 | 4 | 284 | Pseudomonasaeruginosa LpxC in complex with NVS-LPXC-01 [Pseudomonas aeruginosa PAO1],5U3B_B Pseudomonas aeruginosa LpxC in complex with NVS-LPXC-01 [Pseudomonas aeruginosa PAO1],6MAE_A CHAIN A. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase PA-LPXC Complexed with (R)-3-((S)-3-(4-(cyclopropylethynyl)phenyl)-2-oxooxazolidin-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)propenamide [Pseudomonas aeruginosa PAO1] |
| 7K99_A | 1.49e-61 | 2 | 283 | 4 | 284 | CrystalStructure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19 [Pseudomonas aeruginosa PAO1],7K99_C Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19 [Pseudomonas aeruginosa PAO1],7K9A_A Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor [Pseudomonas aeruginosa PAO1],7K9A_C Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor [Pseudomonas aeruginosa PAO1] |
| 6MO4_A | 1.49e-61 | 2 | 283 | 8 | 288 | Co-Crystalstructure of P. aeruginosa LpxC-50067 complex [Pseudomonas aeruginosa PAO1] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| B0US73 | 2.01e-73 | 2 | 283 | 4 | 285 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Histophilus somni (strain 2336) OX=228400 GN=lpxC PE=3 SV=1 |
| Q0I1C7 | 4.02e-73 | 2 | 283 | 4 | 285 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Haemophilus somnus (strain 129Pt) OX=205914 GN=lpxC PE=3 SV=1 |
| Q9CPA5 | 8.05e-73 | 2 | 283 | 4 | 285 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Pasteurella multocida (strain Pm70) OX=272843 GN=lpxC PE=3 SV=1 |
| Q9EV47 | 1.33e-71 | 2 | 283 | 4 | 285 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Shewanella violacea (strain JCM 10179 / CIP 106290 / LMG 19151 / DSS12) OX=637905 GN=lpxC PE=3 SV=1 |
| Q2W0G6 | 2.75e-71 | 2 | 282 | 3 | 284 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) OX=342108 GN=lpxC PE=3 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000047 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |