CAZyme Information: MGYG000000481_00909

Basic Information

• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; CAG-382; UMGS1387
• CAZyme ID: MGYG000000481_00909
• CAZy Family: GH29
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
344		39333.33	5.0109

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000481	2443498	MAG	Fiji	Oceania

• Gene Location: Start: 5842; End: 6876 Strand: +

Full Sequence      

MNNGYEWFKEAKYGMMVHWGLYSLLAGEYRGKPVKSYAEWIMSMFKISINEYEKLASVFN
PIYFDAEEWALFAKKCGMKYVVITAKHHDGFAMFDSFDPFNVKKATPFGRDVIAELSSAC
RKYGLRFGIYYSQDLDWHDPNGGGYFQKNDETAGNGWTNNWDFPDDDNKDYGKCLYGKII
PQIKELLTNYGDISVLWFDMPMTSTFEQSKLLYDTVKELQPDCLVSSRLGNGCYDYVSLG
DNEIPQNIDEWKEKTKNQIGDNVDYRGINGFKPSKYGLYETAATTNSSWGFKYRDQNWKT
AEKIAESRNRLNSMGINYLINVGPDGLGRIPGPAMEALLGAAEI

Enzyme Prediction     

No EC number prediction in MGYG000000481_00909.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH29	5	340	8.7e-80	0.838150289017341

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam01120	Alpha_L_fucos	8.86e-75	6	339	20	321	Alpha-L-fucosidase.
smart00812	Alpha_L_fucos	2.36e-67	6	339	21	323	Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis.
COG3669	AfuC	4.74e-31	51	343	41	310	Alpha-L-fucosidase [Carbohydrate transport and metabolism].
pfam14871	GHL6	1.53e-04	65	157	1	102	Hypothetical glycosyl hydrolase 6. GHL6 is a family of hypothetical glycoside hydrolases.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AWM74571.1	7.26e-157	2	344	4	338
AIS08437.1	1.03e-156	2	344	4	338
AWN32758.1	2.40e-155	2	344	4	338
QYN60528.1	1.01e-154	6	344	6	340
AKV55318.1	3.34e-153	6	344	6	340

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6O18_A	3.88e-154	1	344	1	338	ChainA, AlfC [Lacticaseibacillus casei],6O18_B Chain B, AlfC [Lacticaseibacillus casei],6O18_C Chain C, AlfC [Lacticaseibacillus casei],6O18_D Chain D, AlfC [Lacticaseibacillus casei],6O1A_A Chain A, AlfC [Lacticaseibacillus casei],6O1A_B Chain B, AlfC [Lacticaseibacillus casei],6O1A_C Chain C, AlfC [Lacticaseibacillus casei],6O1A_D Chain D, AlfC [Lacticaseibacillus casei]
6O1I_A	3.17e-153	1	344	1	338	ChainA, AlfC [Lacticaseibacillus casei],6O1I_B Chain B, AlfC [Lacticaseibacillus casei],6O1I_C Chain C, AlfC [Lacticaseibacillus casei],6O1I_D Chain D, AlfC [Lacticaseibacillus casei]
6O1J_A	6.38e-153	1	344	1	338	ChainA, AlfC [Lacticaseibacillus casei],6O1J_B Chain B, AlfC [Lacticaseibacillus casei],6O1J_C Chain C, AlfC [Lacticaseibacillus casei],6O1J_D Chain D, AlfC [Lacticaseibacillus casei],6O1J_E Chain E, AlfC [Lacticaseibacillus casei],6O1J_F Chain F, AlfC [Lacticaseibacillus casei],6O1J_G Chain G, AlfC [Lacticaseibacillus casei],6O1J_H Chain H, AlfC [Lacticaseibacillus casei]
6O1C_A	6.38e-153	1	344	1	338	ChainA, AlfC [Lacticaseibacillus casei],6O1C_B Chain B, AlfC [Lacticaseibacillus casei],6O1C_C Chain C, AlfC [Lacticaseibacillus casei],6O1C_D Chain D, AlfC [Lacticaseibacillus casei],6O1C_E Chain E, AlfC [Lacticaseibacillus casei],6O1C_F Chain F, AlfC [Lacticaseibacillus casei],6O1C_G Chain G, AlfC [Lacticaseibacillus casei],6O1C_H Chain H, AlfC [Lacticaseibacillus casei],6OHE_A Chain A, AlfC [Lacticaseibacillus casei],6OHE_B Chain B, AlfC [Lacticaseibacillus casei],6OHE_C Chain C, AlfC [Lacticaseibacillus casei],6OHE_D Chain D, AlfC [Lacticaseibacillus casei]
6GN6_A	4.52e-53	6	338	32	337	Alpha-L-fucosidaseisoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_B Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_C Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_D Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_E Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_F Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P10901	8.43e-23	7	339	36	347	Alpha-L-fucosidase OS=Dictyostelium discoideum OX=44689 GN=alfA PE=3 SV=1
P17164	9.62e-20	6	343	47	356	Tissue alpha-L-fucosidase OS=Rattus norvegicus OX=10116 GN=Fuca1 PE=1 SV=1
Q99LJ1	2.27e-19	6	343	37	346	Tissue alpha-L-fucosidase OS=Mus musculus OX=10090 GN=Fuca1 PE=1 SV=1
Q60HF8	6.71e-18	6	327	53	348	Tissue alpha-L-fucosidase OS=Macaca fascicularis OX=9541 GN=FUCA1 PE=2 SV=1
Q9BTY2	1.22e-17	7	199	49	228	Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000070	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000481_00909.